165 results match your criteria: "Knuckle Pads"
Palmoplantar keratoderma, knuckle pads, and syndactyly associated with a new missense variant in the SLURP1 gene.
Int J Dermatol
December 2024
Department of Dermatology, Hospital del Mar, Barcelona, Spain.
CASTing the net wider: A case report of PLACK syndrome associated with dilated cardiomyopathy.
Pediatr Dermatol
November 2024
Department of Internal Medicine, Division of Dermatology, Dell Medical School, University of Texas, Austin, Texas, USA.
Article Synopsis
- PLACK syndrome is a rare genetic skin condition associated with symptoms like peeling skin, white nails, and knuckle pads, caused by mutations in the CAST gene that affects a specific protease.
- This case report discusses a patient with PLACK syndrome who showed unusual palm hyperkeratosis and developed serious heart issues, specifically cardiomyopathy.
- The report emphasizes the need to understand how CAST mutations can affect heart health and highlights the possible links between PLACK syndrome and cardiac problems.
A Rare Case on Capecitabine Induced Acquired Palmoplantar Keratoderma.
Clin Cosmet Investig Dermatol
December 2023
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Acquired palmoplantar keratoderma (PPK) is a non-hereditary hyperkeratosis of the palms and soles that is caused by various factors, including chemotherapeutic agents. The purpose of this case report is to present a rare case of acquired PPK caused by the chemotherapeutic agent capecitabine. A 54-year-old female complained of painful erythematous plaques on her palms and soles with history of consuming capecitabine.
View Article and Find Full Text PDFArticle Synopsis
- Collagenase clostridium histolyticum (CCH) is a non-surgical treatment for Dupuytren Disease, but recurrence rates are high and predictors of these outcomes are not well understood.
- A study of 74 patients over 5 years showed a 67% recurrence rate after CCH treatment, with no correlation found between the Dupuytren Diathesis Score (DDS) and recurrence.
- However, the presence of knuckle pads was linked to a lower risk of recurrence, and overall patient satisfaction with CCH treatment was reported as high.
Palmoplantar keratoderma, pseudo-ainhum and knuckle pads in an African patient: A case report.
SAGE Open Med Case Rep
October 2023
Department of Internal Medicine, King Edward VIII Hospital, Durban, South Africa.
Article Synopsis
- Hereditary palmoplantar keratoderma is a rare genetic skin condition marked by thickening of the skin on the palms and soles, influenced by various genetic mutations affecting keratin-related proteins.
- A case involving a 29-year-old HIV-positive African woman showcases the complexity of this condition, with her symptoms including painful constriction bands and skin thickening, which led to complications like toe amputation.
- Genetic testing revealed uncertain findings related to specific genes, highlighting the challenges in diagnosis and emphasizing the need for early detection and proper treatment to improve patient quality of life.
Mechanical properties evaluation of metacarpophalangeal joint prosthesis with new titanium-nickel memory alloy: a cadaver study.
BMC Musculoskelet Disord
September 2023
Department of Orthopaedic, 920th Hospital of Joint Logistics Support Force, No. 212 Daguan Road, Xishan District, 650118, Kunming, China.
Article Synopsis
- Ni-Ti memory alloys are promising candidates for hard-tissue replacement due to their superelasticity, biocompatibility, and mechanical strengths, leading to an evaluation for clinical use in prosthetics.
- The study involved testing metacarpophalangeal joint specimens, comparing a prosthesis group with a control group, focusing on axial compression strength, strain changes, and mechanical wear properties.
- Results showed that the prosthesis group had greater stiffness at certain flexion angles but no significant differences in stress changes or pull-out forces, suggesting the Ni-Ti alloy is biomechanically suitable for joint prostheses.
Heterogeneous aggregation of carbon and silicon nanoparticles with benzo[a]pyrene modulates their impacts on the pulmonary surfactant film.
J Hazard Mater
October 2023
Institute of Coastal Environmental Pollution Control, Key Laboratory of Marine Environment and Ecology, Ministry of Education, Ocean University of China, Qingdao 266100, China; Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China. Electronic address:
Article Synopsis
- * Molecular dynamics simulations revealed that silicon NPs (SiNPs) penetrate the PS film with little disturbance, while carbon NPs (CNPs) display more complex interactions that depend on their aggregation and adsorption properties.
- * The study emphasizes the need to account for the varying behaviors of NPs, particularly in terms of their aggregation and how they interact with pollutants, in order to accurately assess inhalation toxicity from airborne NPs.
Knuckle Pads Successfully Treated with 2% Crisaborole Ointment Combined with Triamcinolone Acetonide and Neomycin Plaster: A Case Report.
Clin Cosmet Investig Dermatol
July 2023
Institute of Dermatology, Guangzhou Medical University, Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, People's Republic of China.
Article Synopsis
- * A case study showed successful treatment of KPs using a combination of 2% crisaborole ointment, triamcinolone acetonide, and neomycin plaster.
- * This combined treatment could represent a potential new option for managing knuckle pads effectively.
Effect of shoeing horses with eggbar shoes and shoes with wedge pads on blood flow parameters in the lateral digital artery in the Doppler ultrasound.
Pol J Vet Sci
June 2023
Student of 5th year, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, Olsztyn, 10-719, Poland.
Article Synopsis
- * Results show that egg bar shoes significantly impact blood circulation compared to wedge pads, with changes observed in end-diastolic velocity (EDV) and mean velocity (Vmn) after shoeing.
- * The findings suggest that egg bar shoes create increased pressure at the heel bulbs, leading to more variable blood flow patterns, while wedge pads reduce pressure and have a more consistent low-resistance blood flow pattern.
Dual role of pulmonary surfactant corona in modulating carbon nanotube toxicity and benzo[a]pyrene bioaccessibility.
J Hazard Mater
September 2023
Institute of Coastal Environmental Pollution Control, Key Laboratory of Marine Environment and Ecology, Ministry of Education, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao 266100, China. Electronic address:
Article Synopsis
- Inhaled carbon nanotubes (CNTs) can interact with pulmonary surfactant (PS) in the lungs, affecting their toxicity and behavior.
- * This study used fluorescence techniques to show that PS can partially dissolve certain contaminants (BaPs) attached to CNTs, influencing their effects in the respiratory system.
- * The research revealed that while PS can reduce the toxicity of CNTs by altering their physical properties, they may also increase the potential harm from coexisting contaminants like BaP, emphasizing the need to consider these interactions when evaluating inhalation risks.
A case of knuckle pad syndrome in a middle-aged man.
Clin Case Rep
December 2022
Division of Rheumatology and Clinical Immunology, Department of Medicine UF COM - Jacksonville Jacksonville Florida USA.
Article Synopsis
- Knuckle pads are non-cancerous growths that appear as bumps on the joints, mainly at the base of the fingers.
- They can sometimes be mistaken for other skin or joint diseases.
- Treatment options are limited for primary knuckle pads, while those that develop from an external cause often improve when the trigger is removed.
"African" acral keratoderma: Further evidence for a single entity. A retrospective study of 42 patients.
Ann Dermatol Venereol
March 2023
Department of Dermatology, APHP, Saint-Louis Hospital, 75010 Paris, France.
Article Synopsis
- - The study explores various phenotypes of non-inflammatory palmar and plantar keratoderma (PPK) prevalent in Sub-Saharan African patients, proposing they might collectively be known as "African Acral Keratoderma" (AAK).
- - A review of 42 patients over 11 years revealed that most displayed mixed forms of keratoderma, with a significant proportion (40%) having familial histories, suggesting a potential genetic link.
- - Findings support the AAK concept, with the majority receiving topical treatments, and the rare condition "ainhum" managed surgically.
Bart-Pumphrey syndrome and recurrent cholesteatoma: a casual association?
Int J Dermatol
April 2023
Department of Genetics, Complejo Hospitalario Universitario de Canarias, Tenerife, Spain.
Nonsense mutations in KRT1 caused recessive epidermolytic palmoplantar keratoderma with knuckle pads.
J Eur Acad Dermatol Venereol
October 2022
Dermatology Hospital, Southern Medical University, Guangzhou, China.
Article Synopsis
- Epidermolytic palmoplantar keratoderma (EPPK) is a skin disorder caused by mutations in the KRT9 or KRT1 genes, leading to thickened skin on palms and soles.
- This study focused on two unrelated Chinese patients with EPPK and knuckle pads, using advanced genetic and protein analysis techniques to investigate their condition.
- The researchers identified two new harmful mutations in the KRT1 gene that disrupt normal keratin production, which they believe contributed to EPPK, while suggesting that the skin's compensatory mechanisms might protect other areas from severe symptoms.
Skin Biter: Dermatodaxia Revisited.
Cureus
February 2022
Dermatology, University of California, Davis Medical Center, Sacramento, USA.
Dermatodaxia describes humans who bite their skin. Previously used designations, which are less appropriate, have included chewing pads, wolf-biter, and dermatophagia. Dermatodaxia is a body-focused repetitive behavior and is classified in the category of obsessive-compulsive and related disorders.
View Article and Find Full Text PDFSilicone gel sheets in treatment of pseudo-knuckle pads: a case report.
Dermatol Ther
April 2022
Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
[Benign skin neoplasms in children].
Hautarzt
February 2022
Dermatologie II, Colentina Klinik, Carol-Davila-Universität für Medizin und Pharmazie, Stefan cel Mare Street 19-21, 020125, Bukarest, Rumänien.
Article Synopsis
- There are various types of skin neoplasms in children, most of which are benign, and dermatologists play a crucial role in identifying and recommending treatments for these conditions.
- Surgical removal is often the primary treatment for benign skin neoplasms, highlighting the need for dermatologists to be knowledgeable about different types.
- The paper aims to review various skin lesions and tumors, along with recent advancements in histopathological examinations and genetic studies that enhance understanding of the underlying causes.
Knuckle pads: an ancient disease frequently misdiagnosed because of minimal modern attention.
Dermatol Online J
September 2021
Department of Dermatology, College of Medicine, University of Florida, Gainesville, FL.
Article Synopsis
- * A case study involved a 44-year-old woman with mildly painful nodules on her finger joints, where tests showed no family history of related conditions and negative rheumatoid factor.
- * Diagnosis was confirmed through a skin biopsy, and treatment with an injection significantly improved the patient's condition, emphasizing the need for better awareness of knuckle pads in healthcare.
The Effect of Horse Shoeing with Egg Bar Shoes and Shoes with Wedge Pads on the Results of Thermal Imaging of the Equine Distal Limb.
Animals (Basel)
May 2021
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, al. Warszawska 30, 10-082 Olsztyn, Poland.
Article Synopsis
- The manuscript serves as a guide for practitioners on measuring and controlling hoof temperature after shoeing in horses.
- The study involved 16 horses divided into two groups, one shod with egg bar shoes and the other with wedge pads, with hoof temperature assessed through thermography before and a month after shoeing.
- Results indicated that shoeing with egg bar shoes led to lowered temperatures in the palmar view, while wedge pads also decreased temperatures in both dorsal and palmar views, suggesting minor negative effects on circulation and metabolism in the horse's legs due to shoeing.
Article Synopsis
- * Young adults, especially teenagers, may feel self-conscious about knuckle pads, leading to social anxiety or embarrassment about their appearance.
- * A case study highlights successful treatment using a mix of high-dose salicylic acid and urea, and emphasizes the importance of clear diagnostic images and histological features for differentiating knuckle pads from other related joint conditions.
Knuckle pads mimic early psoriatic arthritis.
Reumatismo
April 2021
Department of Medical and Biological Science, Rheumatology Clinic, University of Udine.
Article Synopsis
- * Accurate diagnosis requires a differential approach, utilizing tools like ultrasound to assess tissue thickening and collaborating with specialists, such as dermatologists, to understand the condition better.
- * The case report discusses a female patient whose knuckle pads presented similar symptoms to psoriatic arthritis, highlighting the importance of proper diagnosis in such conditions.
Article Synopsis
- Videogame controller usage can lead to unique skin changes, specifically knuckle pads, in certain areas of the hands.
- Treatment can effectively relieve this condition by removing the source of irritation, in this case, the videogame controller.
- After addressing the cause, the likelihood of the skin issue returning is significantly reduced.
PLACK syndrome is potentially treatable with intralipids.
Clin Genet
April 2021
Department of Pediatrics, Division of Gastroenterology, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.
Article Synopsis
- The case involves an 11-year-old girl diagnosed with PLACK Syndrome, characterized by skin peeling and other symptoms, who has a new variant in the CAST gene confirmed through RNA testing.* -
- There is no established treatment for PLACK Syndrome, but the patient showed significant improvement after being given intravenous lipid infusion, which included fat-soluble vitamins.* -
- This report highlights the potential for using lipid infusions as a treatment for PLACK Syndrome, suggesting that it could be a viable option for future healthcare studies.*
The biomechanical characteristics of a feline distal forelimb: A finite element analysis study.
Comput Biol Med
February 2021
Faculty of Sports Science, Ningbo University, Ningbo, 315211, China. Electronic address:
Article Synopsis
- Felines have uniquely structured limbs that can support two to three times their body weight, which makes understanding the internal stress distribution in their distal joints critical for analyzing their movement.
- A finite element model (FEM) was created using a healthy feline to simulate stress distribution in its paw and validate findings with experimental pressure measurements while standing.
- The study found that higher stress occurs in the metacarpal segment, which plays a key role in stabilizing the limb, and that insights gained from this research could inform better designs for bionic footwear and treatments for joint injuries in humans.
PLACK syndrome resulting from a novel homozygous variant in CAST.
Pediatr Dermatol
January 2021
Department of Paediatric Dermatology, Children's Health Ireland at Crumlin, Dublin, Ireland.
Article Synopsis
- PLACK syndrome is a genetic skin disorder classified as generalized peeling skin syndrome, linked to mutations in the CAST gene.
- It is inherited in an autosomal recessive manner, meaning both parents must carry the mutation for the child to be affected.
- A case is presented involving a 5-year-old girl who has PLACK syndrome, showing typical symptoms and a specific genetic variant identified in both copies of her CAST gene.