3 results match your criteria: "Knight Cancer Institute (OHSU)[Affiliation]"
CASPER: A Phase I trial combining calaspargase pegol-mnkl and cobimetinib in pancreatic cancer.
Future Oncol
November 2024
Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute (OHSU), OR, Portland.
Asparagine synthetase (ASNS) catalyzes the biosynthesis of asparagine from aspartate and glutamine. Cells lacking ASNS, however, are auxotrophic for asparagine. Use of L-asparaginase to promote asparagine starvation in solid tumors with low ASNS levels, such as pancreatic ductal adenocarcinoma (PDAC), is a rationale treatment strategy.
View Article and Find Full Text PDFSystematic replication enables normalization of high-throughput imaging assays.
Bioinformatics
October 2022
Department of Statistics, University of Michigan, Ann Arbor, MI, USA.
Article Synopsis
- High-throughput fluorescent microscopy is a method used to study tissues and cells by taking lots of images, but sometimes technical problems can get in the way of seeing the real results.
- The researchers created a way to fix these problems using a special design that helps get rid of unwanted noise in the images, which helps to see the important biological information better.
- They used this method on something called microenvironment microarrays (MEMAs) and shared their data and tools online for others to use.
Aurora A kinase as a target for therapy in rearranged acute lymphoblastic leukemia.
Haematologica
November 2021
Division of Hematology and Oncology, Department of Pediatrics and OHSU Knight Cancer Institute. OHSU, Portland, Oregon.