Magnetic resonance imaging using hyperpolarized 3He-Gas.

Rationale And Objectives: Current imaging procedures of the lung concentrate on visualization of morphology. Computed tomography is the imaging method of choice for the majority of pulmonary diseases. Functional data are commonly obtained from arterial blood gas analysis, spirometry, and body plethysmography, which all suffer from lack of regional information.

Distribution of ventilation in lung transplant recipients: evaluation by dynamic 3He-MRI with lung motion correction.

Rationale And Objectives: The ability of motion corrected dynamic 3He-magnetic resonance imaging (MRI) to discriminate distributional patterns of inhaled hyperpolarized 3He between different groups of lung transplant recipients was evaluated.

Methods: An ultrafast low-angle shot 2D sequence (temporal resolution 128 ms) was used for ventilation 3He-MRI of 11 single and 6 double lung transplant recipients. After digital motion correction, signal kinetics were evaluated in a tracheal and 7 pulmonary regions of interest.

Dynamic ventilation (3)He-magnetic resonance imaging with lung motion correction: gas flow distribution analysis.

Rationale And Objectives: Software was developed to correct for lung motion to improve the description of hyperpolarized (3)He gas distribution in the lung.

Methods: Five volunteers were studied by dynamic ventilation (3)He-MRI using an ultrafast FLASH 2D sequence with a temporal resolution of 128 milliseconds. Signal kinetics were evaluated in the trachea and seven parenchymal Regions of Interest.