Endovascular Treatment of Basilar Artery Occlusion: What Can We Learn from the Results?

Background and Objectives: Current guidelines lack specific endovascular treatment (EVT) recommendations for posterior circulation stroke (PCS). The results of earlier studies are controversial. We aimed to compare early hospital outcomes of stroke caused by large-vessel occlusion (LVO) treated with EVT or bridging therapy (BT) in anterior circulation stroke (ACS) versus PCS (middle cerebral artery occlusion (MCAO) and basilar artery occlusion (BAO), and establish the risk factors for poor outcome.

A phase III randomized, multicentre, double blind, active controlled trial to compare the efficacy and safety of two different anagrelide formulations in patients with essential thrombocythaemia - the TEAM-ET 2·0 trial.

Anagrelide is an established treatment option for essential thrombocythaemia (ET). A prolonged release formulation was developed with the aim of reducing dosing frequency and improving tolerability, without diminishing efficacy. This multicentre, randomized, double blind, active-controlled, non-inferiority trial investigated the efficacy, safety and tolerability of anagrelide prolonged release (A-PR) over a reference product in high-risk ET patients, either anagrelide-naïve or -experienced.

Stress and Fatigue Management Using Balneotherapy in a Short-Time Randomized Controlled Trial.

Objective. To investigate the influence of high-salinity geothermal mineral water on stress and fatigue. Method.

Safety and Efficacy of Fedratinib in Patients With Primary or Secondary Myelofibrosis: A Randomized Clinical Trial.

Importance: Myelofibrosis (MF) is a BCR-ABL-negative myeloproliferative neoplasm characterized by anemia, splenomegaly, debilitating constitutional symptoms, and shortened survival. Fedratinib, a JAK2-selective inhibitor, previously demonstrated clinically beneficial activity in patients with MF in early-phase trials.

Objective: To evaluate the efficacy and safety of fedratinib therapy in patients with primary or secondary (post-polycythemia vera or post-essential thrombocythemia) MF.

Association between environment and psycho-emotional stress experienced at sea by Lithuanian and Latvian seamen.

This is the first scientific research in Lithuania and Latvia that involves a national cross-sectional study of the seamen of two different countries--Lithuania and Latvia--including the evaluation and comparison of seamen's working environment, lifestyle, health, the prevalence of health-damaging risk factors, as well as the causative relationships between the objective and subjective health evaluation and psycho-emotional stress experienced at sea. The aim of the study was to investigate the frequency and predictors of the psycho-emotional stress experienced at sea by Lithuanian and Latvian seamen. Beside the common statistical methods, the logistic stepwise regression analysis was used in order to find the risk factors of the self-rated stress and to correct the risk estimates for the confounding variables.

[Comparative analysis of nourishment of Lithuanian and Latvian seafarers at sea].

Objective: To evaluate and compare the nourishment of Lithuanian and Latvian seafarers at sea.

Material And Methods: The present pilot study was comprised of 997 Lithuanian and 993 Latvian seafarers applying for obligatory medical examination. Participants were asked to fill out a questionnaire consisting of 44 questions.

Prevalence of hypertension in Lithuanian mariners.

Several international studies from Spain, the Netherlands, Poland, Croatia, and Finland indicate contradicting findings regarding cardiovascular dysfunction among seamen, deep sea fishermen, and harbor workers. The purpose of the present survey was to evaluate the prevalence of hypertension in a selected group of Lithuanian seamen. The survey was conducted during a one year period and involved sailors from commercial, passenger, and fishing boats.

Impact of obesity on lipid profiles in middle-aged women.

Objective: The goal of the study was to analyze the impact of overweight on lipid and apolipoprotein A-I and B (apoA-I, apoB) profiles in the women's blood serum.

Material And Methods: Seventy-five women without any symptoms of coronary heart disease were examined. Women were divided into two groups: those with normal weight and the body mass index (BMI) less than 25 (n=34, BMI 22.

[Relationship of paradoxical vasoconstriction induced by acetylcholine to risk factors for ischemic heart disease].

Acetylcholine test is widely used for the investigation of endothelium function. Acetylcholine induces paradoxical vasoconstriction, if endothelium of coronary artery is damaged. The aim of this study was to investigate the endothelium dysfunction among the patients who have complaints of the chest pain and at the same time no significant changes are found in their coronary arteries by angiography.

[Oxidative stress and endothelial dysfunction].

Growing numbers of morbidity and mortality due to the Coronary Heart Disease (CHD) is recognized as the more increasing challenge in the world. The initial stage of atherosclerosis, early diagnosis and treatment of CHD are the main objectives of current research. Endothelium dysfunction, the earliest expression of the atherosclerotic process is associated with subtle biochemical changes that gradually are transformed into the structural changes of the arterial wall.

[Pathology of cardiovascular system among hemodialysis patients in Lithuania].

During period of February to July 2002 the data of 602 hemodialysis patients were collected from 20 dialysis centres in Lithuania in order to determine the prevalence of cardiovascular diseases and their risk factors. In 34.9 percent of patients ischemic heart disease was diagnosed (myocardial infarction prior to hemodialysis, angina pectoris according to Rose's questionnaire, scar changes in ECG and/or hypokinesis zones in echocardiograms).

[Effect of high doses of atorvastatin on the endothelial function of the coronary arteries].

Objective: The aim of this study is to investigate the role of high doses of atorvastatin (80 mg per day) in the treatment of endothelium dysfunction of the coronary arteries.

Material And Methods: Intracoronary acethylcholine test was performed for 28 (16 in treatment group and 12 in control group) patients who had normal coronary angiogram or minimal lesions (stenosis <50%) and symptomatic coronary heart disease. Acetylcholine was given into left coronary artery in three stages (2 min each) at estimated intracoronary concentrations 10(-6) mol/l, 3.

[Coronary atherosclerosis and blood groups of ABO system in women (own data and review)].

Unlabelled: Earlier we have shown significantly more frequent B blood group and a significantly more rare O blood group of ABO blood group system in men aged under 45 years suffering from coronary atherosclerosis compared with these frequencies in the population of Lithuania. The aim of the study was to investigate the frequency of blood groups of ABO system in women with coronary atherosclerosis.

Materials: The frequency of the ABO blood groups was examined in 441 women, suffering from coronary atherosclerosis, divided into two groups: I group - 109 women till 60 years old (mean age 55.

[The influence of factor VII deficiency on cardiac operations with extracorporeal circulation].

During preoperative blood coagulation testing the factor VII (FVII) deficiency was found in two patients. No liver disease or cardiac insufficiency was found. No history of bleeding episodes existed.

Lithuanian haemophilia A and B registry comprising phenotypic and genotypic data.

Haemophilia represents the most common hereditary severe bleeding disorder in humans. About 100 families with this condition live in Lithuania, one of the Baltic states with a population of 3.7 million.