6,506 results match your criteria: "Kitasato University school of Medicine[Affiliation]"
4K Indocyanine Green Endoscope Contributes to Preserve Normal Pituitary Functions Through Visualization of Normal Pituitary Body With Indocyanine Green Signals in the Operation for Rathke Cleft Cyst: 2-Dimensional Operative Video.
Oper Neurosurg (Hagerstown)
October 2024
Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Correction of lower limb deformity in an adult patient with Ellis-van Creveld syndrome: a rare case report.
J Surg Case Rep
October 2024
Department of Orthopedic Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan.
Article Synopsis
- Ellis-van Creveld syndrome (EVC) is a rare condition characterized by knee deformities, particularly affecting younger patients, with limited adult treatment documentation.
- A 23-year-old woman presented with bilateral knee pain and abnormal walking due to valgus knee deformities, which were confirmed through imaging.
- The surgical approach included osteotomies of the femurs and tibias, achieving good correction; despite mild residual deformity, the patient maintained stable and painless walking for 10 years after surgery.
Low Nutrition before Injury Is a Risk Factor for Dysphagia in Older Patients with Cervical Spinal Cord Injury: Based on a Multicenter Data of 707 Patients.
Spine Surg Relat Res
September 2024
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Article Synopsis
- Dysphagia, a serious swallowing disorder, affects older adults post-spinal cord injury, particularly those with cervical injuries, though its risk factors are not well understood.
- A study involving 707 patients aged 65 and older identified male sex, low nutritional status (GNRI <92), dementia, fractures, complete paralysis, anterior surgery, and tracheostomy as significant risk factors for dysphagia.
- The findings suggest that a low geriatric nutritional risk index (GNRI) is a key indicator of dysphagia risk, implying that nutritional health is critical for recovery in elderly patients with cervical spinal injuries.
-Schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis.
RSC Med Chem
September 2024
Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University 5-9-1 Shirokane Minato-ku Tokyo 108-8641 Japan
The incorporation of saturated nitrogen-containing heterocycle 1,2,5-oxadiazinane into small molecules represents a compelling avenue in drug discovery due to its unexplored behavior within biological systems and incomplete protocols for synthesis. In this study, we present 1,2,5-oxadiazinane, an innovative heterocyclic bioisostere of piperizin-2-one and novel chemotype of the -schistosomal drug praziquantel (PZQ), which has been the only clinical drug available for three decades. PZQ is associated with significant drawbacks, including poor solubility, a bitter taste, and low metabolic stability.
View Article and Find Full Text PDFHigh likelihood of BRCA2 reversion mutation in pancreatic cancer post-platinum-based chemotherapy: a case study.
Int Cancer Conf J
October 2024
Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa 252-0374 Japan.
A 54-year-old man with resectable pancreatic cancer and abnormally high levels of carbohydrate antigen 19-9 (CA19-9) underwent 6 months of platinum-based chemotherapy. This treatment substantially reduced the primary tumor size and normalized CA19-9 levels. Subsequently, radical surgery was conducted.
View Article and Find Full Text PDFFrequency and severity of hyponatremia in healthy children with acute illness.
Pediatr Nephrol
March 2025
Department of Nephrology and Rheumatology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan.
Article Synopsis
- Hyponatremia is a condition marked by low sodium levels and can occur during the acute phase of many illnesses, but its prevalence and severity in various medical situations is not fully understood.
- A study at Tokyo Metropolitan Children's Medical Center reviewed 2,717 urgent pediatric admissions and found that 260 (13.8%) had hyponatremia, with type 1 diabetes being the most common associated condition (69%).
- The research highlighted significant hyponatremia in conditions like Kawasaki disease and acute infectious encephalopathy, but noted that conditions like acute bronchial asthma or fractures rarely showed low sodium levels upon arrival.
Hemostasis using a novel self-assembling peptide for a bleeding gastric hyperplastic polyp after endoscopic resection.
Endoscopy
December 2024
Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.
Spontaneous Complete Chorioamniotic Membrane Separation in a Fetus With Ileal Atresia and Umbilical Cord Ulcer: A Case Report.
J Clin Ultrasound
February 2025
Department of Obstetrics and Gynecology, Kitasato University School of Medicine, Sagamihara, Japan.
Spontaneous complete chorioamniotic membrane separation (cCMS) is rare and associated with adverse perinatal outcomes, such as intrauterine fetal death. Herein, we present a case of spontaneous cCMS in a fetus with ileal atresia and umbilical cord ulcers. In our case, we detected spontaneous cCMS on ultrasonography at 35 weeks of gestation.
View Article and Find Full Text PDFSerum Lipoprotein(a) Levels and Their Association with Atherosclerotic Cardiovascular Disease in Japan.
J Atheroscler Thromb
October 2024
Department of Cardiology, Rinku General Medical Center.
Article Synopsis
- The study aimed to explore the levels of lipoprotein(a) (Lp(a)) and its link to atherosclerotic cardiovascular disease (ASCVD) in high-risk Japanese patients, using health insurance database data.
- Researchers analyzed data from patients who qualified for ASCVD prevention and had Lp(a) tests, separating them into three risk groups and collecting relevant health data.
- Findings revealed that only a small percentage of patients were tested for Lp(a), yet those with higher levels of Lp(a) showed a greater occurrence of ASCVD, raising concerns about the low testing rates in this high-risk population.
Guidelines for the diagnosis and treatment of idiopathic portal hypertension, extrahepatic portal obstruction, and Budd-Chiari syndrome in Japan.
Hepatol Res
November 2024
Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Article Synopsis
- The text provides an English version of the 2018 guidelines for diagnosing and treating idiopathic portal hypertension, extrahepatic portal obstruction, and Budd-Chiari syndrome.
- These guidelines were developed by the Aberrant Portal Hemodynamics Study Group and are overseen by Japan's Ministry of Health, Labor, and Welfare.
- The full guidelines contain 86 clinical questions and explanations, spanning 183 pages in Japanese.
Deletion of TP signaling in macrophages delays liver repair following APAP-induced liver injury by reducing accumulation of reparative macrophage and production of HGF.
Inflamm Regen
October 2024
Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.
Article Synopsis
- Acetaminophen (APAP) can cause significant liver damage, and macrophages are critical for healing this injury; however, the role of thromboxane A (TXA) and its receptor in this process is not well understood.
- Research involved both TP knockout mice and wild-type mice treated with APAP to examine liver inflammation and repair.
- Results showed that lack of TP signaling in macrophages worsened liver injury and delayed repair, highlighting the importance of TP in supporting macrophage function and promoting recovery from APAP-induced liver damage.
Pre-disaster income inequality and post-disaster mental health: A natural experiment from the 2011 Great East Japan Earthquake and Tsunami.
Health Place
November 2024
Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Article Synopsis
- This study investigated how income inequality in communities affects mental health after disasters, specifically looking at older adults following the 2011 Great East Japan Earthquake.
- The researchers used a cohort of individuals over 65, assessing their mental health through surveys and measuring community income inequality with the Gini index before and after the disaster.
- Results revealed that higher pre-disaster income inequality correlated with increased post-traumatic stress symptoms, suggesting potential links between inequality, mental health, and changes in social capital post-disaster that need further exploration for effective policy recommendations.
A case of immune checkpoint inhibitor-associated hemophagocytosis after initiation of atezolizumab plus bevacizumab therapy for advanced hepatocellular carcinoma.
Clin J Gastroenterol
December 2024
Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Kitasato University Hospital, 1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
A woman in the 70s with a decreased appetite and weight loss (4 kg) in the last 3 months was referred to our hospital. An enhanced CT scan of the abdomen showed a hepatocellular carcinoma (HCC) of 83 mm in diameter of the liver with metastasis to the para-aortic lymph nodes, the left adrenal gland, and the right lower lung lobe (cStage IVb). She was started on atezolizumab + bevacizumab (Atezo-Bev) therapy.
View Article and Find Full Text PDF[Diagnosis and treatment of aplastic anemia and lower-risk myelodysplastic neoplasms].
Rinsho Ketsueki
October 2024
Department of Hematology, Kitasato University School of Medicine.
Article Synopsis
- * Immunosuppressive therapies (IST) are particularly beneficial for patients with lower-risk MDS, especially those with certain bone marrow characteristics.
- * Accurately diagnosing lower-risk MDS can be challenging and requires careful evaluation of the bone marrow, with IST recommended as the first-line treatment for those showing signs of immune-related bone marrow failure.
Effect of the Xanthine Oxidase Inhibitor Febuxostat on the Cardio-Ankle Vascular Index in Asymptomatic Patients with Hyperuricemia and Liver Dysfunction: A Sub-Analysis of the PRIZE Study.
J Atheroscler Thromb
October 2024
Department of Cardiovascular Medicine, Saga University.
Article Synopsis
- The study aimed to investigate the long-term impacts of the drug febuxostat on arterial stiffness in patients with high uric acid levels, with a particular focus on liver function.
- In the PRIZE study, patients were randomly assigned to either receive febuxostat or non-drug treatments, with assessments of arterial stiffness conducted at 12 and 24 months.
- While overall changes in arterial stiffness were not significantly different between the two groups, those with elevated liver enzyme levels showed notable improvements after 24 months of febuxostat treatment.
A randomized phase III study evaluating dexamethasone-based mouthwash to prevent chemotherapy-induced stomatitis in patients with breast cancer.
Jpn J Clin Oncol
February 2025
Department of Breast and Medical Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
Article Synopsis
- A multicenter phase III trial is being conducted to evaluate a dexamethasone-based mouthwash for preventing chemotherapy-induced stomatitis in early breast cancer patients.
- The study will involve 230 patients, randomly assigned to either the dexamethasone mouthwash group or a control group using tap water as mouthwash.
- The main goal is to measure the effectiveness of the mouthwash in reducing the incidence of stomatitis, tracked through electronic patient-reported outcomes.
Editorial: Community series in the role of CD1- and MR1-restricted T cells in immunity and disease, volume II.
Front Immunol
October 2024
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States.
Esophageal Varices as an Independent Predictor of Fatal Outcomes after Balloon-Occluded Retrograde Transvenous Obliteration in Patients with Hepatic Encephalopathy.
Dig Dis
December 2024
Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Article Synopsis
- The study analyzed 107 patients undergoing balloon-occluded retrograde transvenous obliteration (BRTO) due to uncontrollable hepatic encephalopathy (HE) and assessed the impact of esophageal varices (EVs) on outcomes.
- Patients were divided into two groups based on the presence of EVs, and results showed that those with EVs had significantly shorter event-free survival and overall survival compared to those without EVs.
- The findings suggest that having EVs may indicate a higher risk of complications and mortality following the BRTO procedure in HE patients.
JCS/JCC/JSPCCS 2024 Guideline on Genetic Testing and Counseling in Cardiovascular Disease.
Circ J
November 2024
Genome Medical Science Project, National Center for Global Health and Medicine.
RAMP1 Signaling Mitigates Acute Lung Injury by Distinctively Regulating Alveolar and Monocyte-Derived Macrophages.
Int J Mol Sci
September 2024
Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Japan.
Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that induces cytokine hypersecretion. Receptor activity-modifying protein (RAMP) 1, a subunit of the calcitonin gene-related peptide (CGRP) receptor, regulates the production of cytokines. This study examined the role of RAMP1 signaling during lipopolysaccharide (LPS)-induced acute lung injury (ALI).
View Article and Find Full Text PDFCAF-Associated Genes in Breast Cancer for Novel Therapeutic Strategies.
Biomedicines
August 2024
Division of Advanced Surgical Oncology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.
Breast cancer (BC) is the most common cancer in women, and therapeutic strategies for it are based on the molecular subtypes of luminal BC, HER2 BC, and triple-negative BC (TNBC) because each subtype harbors different unique genetic aberrations. Recently, features of the tumor microenvironment (TME), especially cancer-associated fibroblasts (CAFs), have been demonstrated to play a critical role in BC progression, and we would like to understand the molecular features of BC CAFs for novel therapeutic strategies. In a recent study, 115 CAF-associated genes (CAFGs) were identified in a public database of microdissection and microarray data (GSE35602) from 13 colorectal cancer (CRC) tumors.
View Article and Find Full Text PDFTreatment selection pattern and prognostic factors in older patients with non-small cell lung cancer at recurrence: an observational study.
Surg Today
September 2024
Department of Thoracic Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
Purpose: Society is aging, and the proportion of older patients with lung cancer is increasing. However, the treatment choices and prognoses for older patients with cancer recurrence remain unclear. We retrospectively investigated the treatment choices and prognoses of older patients with recurrence.
View Article and Find Full Text PDFA comprehensive assessment tool of acute-phase rehabilitation is associated with clinical outcomes in patients after cardiovascular surgery.
Heart Vessels
March 2025
Department of Cardiovascular Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
Article Synopsis
- The Perme intensive care unit (ICU) mobility score is evaluated for its effectiveness in predicting recovery outcomes for patients after cardiovascular surgery.
- After analyzing data from 249 patients, the study found that higher Perme Scores correlated with quicker recovery in mobility and better physical performance at discharge.
- Additionally, a higher Perme Score is linked to lower rates of death and unplanned readmissions, suggesting it may serve as a valuable tool for anticipating patient outcomes post-surgery.
Prognostic factors after radical local therapy for oligo-recurrence of non-small cell lung cancer.
Gen Thorac Cardiovasc Surg
September 2024
Department of Thoracic Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
Objective: Oligo-recurrence refers to the presence of a limited number of metachronous recurrences that can be treated with radical local therapy, and most patients have a good prognosis. However, the clinical course after local therapy for oligo-recurrence of non-small cell lung cancer (NSCLC) varies, and the prognostic factors are unclear. The aim of this study was to elucidate the prognostic factors of patients with oligo-recurrence of NSCLC who underwent radical local therapy.
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