Demographic and work-related correlates of general and workplace loneliness among employees in Japan: A large-scale descriptive cross-sectional study.

Objectives: Research was limited on demographic and work-related characteristic of general and workplace loneliness. The present descriptive cross-sectional study aimed to know demographic and work-related correlates of general and workplace loneliness in a general working population of Japan.

Methods: We recruited 25,000 persons aged 20 years old or older and employed by a company, organization, or government agency.

-Schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis.

The incorporation of saturated nitrogen-containing heterocycle 1,2,5-oxadiazinane into small molecules represents a compelling avenue in drug discovery due to its unexplored behavior within biological systems and incomplete protocols for synthesis. In this study, we present 1,2,5-oxadiazinane, an innovative heterocyclic bioisostere of piperizin-2-one and novel chemotype of the -schistosomal drug praziquantel (PZQ), which has been the only clinical drug available for three decades. PZQ is associated with significant drawbacks, including poor solubility, a bitter taste, and low metabolic stability.