Offline Adaptive Radiotherapy for Large Non-small Cell Lung Cancer With Volumetric Modulated Arc Therapy Replanning After Creation of Dose Distribution Using Cone-Beam Computed Tomographic Images of Image-Guided Radiotherapy.

There is a paucity of studies reporting the use of automated contouring function on cone-beam computed tomography (CBCT) images acquired during image-guided radiotherapy (IGRT) with offline adaptive radiotherapy for locally advanced non-small cell lung cancer (NSCLC). This case report discusses the use of an automated contouring function on CBCT images acquired during IGRT to quantify the dose distribution variations associated with tumor shrinkage in a patient with large NSCLC. A 72-year-old woman with locally advanced squamous cell carcinoma of the lung (T4N1M0; tumor diameter: 14 cm) underwent chemoradiotherapy.

A twenty-year dataset of hourly energy generation and consumption from district campus building energy systems.

Distributed energy resources (DERs) would play a crucial role in the transition towards decentralized and decarbonized energy systems. However, due to the limited availability of long-term, high-resolution datasets, there has been little research on the descriptive analysis of distributed energy systems throughout the lifespan of distributed power generators and beyond. To address this challenge, this study has collected and described a twenty-year dataset (from 2002 to 2021) consisting of hourly energy generation and consumption profiles from a campus distributed energy system, covering the entire lifespan of on-site generators.

Optimal Intravascular Ultrasound-Guided Percutaneous Coronary Intervention in Patients With Multivessel Disease and Chronic Kidney Disease.

There is a scarcity of data on clinical outcomes after intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) in patients with multivessel disease and chronic kidney disease (CKD). The Optimal Intravascular Ultrasound (OPTIVUS)-Complex PCI study multivessel cohort was a prospective multicenter single-arm trial enrolling 1,015 patients who underwent multivessel IVUS-guided PCI including left anterior descending coronary artery target with an intention to meet the prespecified OPTIVUS criteria for optimal stent expansion. We compared the clinical outcomes between patients with and without CKD.

International trends in biliary tract cancer-related mortality, 2000-2022: An observational study of the World Health Organization mortality database.

Background Aims: Biliary tract cancers (BTCs), including intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma (eCCA), gallbladder cancer (GBC), and ampullary cancer, exhibit poor prognosis. This study examined temporal trends in mortality due to BTCs and their major subtypes at international, regional, and national levels.

Approach Results: This observational study used the World Health Organization mortality database.

A new species of Gosline, 1951 (Actinopterygii, Ophichthidae) from Taiwan.

A unique species of the flappy-snake eel genus, , is described based on a single specimen (270 mm in total length) collected from Dong-gang, southwestern Taiwan. The new species possesses several characters that are distinct from the only other species in the genus, . can be easily distinguished from by having two papillae inside of nasal tube (vs three in ), 25 branchiostegal rays (vs 29), the dorsal-fin origin positioned behind the tip of the pectoral fin (vs not behind, usually above mid-pectoral fin), and the absence of the maxillary teeth (vs present).

Description of a new uniformly brown estuarine moray eel (Anguilliformes, Muraenidae) from the Central Indo-Pacific Ocean.

A new estuarine moray eel, , is described based on 14 specimens from Japan, Taiwan, the Philippines, southern Indonesia, and Fiji. It is a small-bodied, slender, uniformly dark-brown moray separated from congeners within the species complex. The new species can be distinguished from congeners by the anteriorly positioned small eyes (5.

Species of the snake eel genus Whitley, 1940 from Taiwan, with descriptions of a new species and two new records (Anguilliformes, Ophichthidae).

The slender snake eel genus from Taiwan is reviewed, and a total of four species are recognized, including a new species described here. is described based on four specimens collected from western Taiwan. It can be distinguished from congeners by the dorsal-fin origin situated above the gill opening, the tip of lower jaw not reaching the base of the anterior-nostril tube, 1 + 3 supraorbital pores, 7-8 predorsal vertebrae, and 147-152 total vertebrae.

Descriptions of two new dark-body snake eels of the genus (Anguilliformes, Ophichthidae) from Taiwan.

Two new species of dark-body snake eels are described based on specimens collected from Taiwan. has a long tail; dorsal-fin origin above posterior third of pectoral fin; tip of lower jaw anterior to anterior-nostril tube; two simple, pointed protrusions along upper lip; preoperculomandibular pores 6 or 7 + 3; teeth on jaws and vomer mostly uniserial, except for biserial on posterior portion of maxilla and anterior portion of symphysis of dentary; vertebral formula 12-55-153 and median fins with narrow dark margins, except the pale fin origins. has a dorsal-fin origin well behind gill opening; mainly 4 rows of teeth on jaws; no protrusions along upper lip; a smaller head; mean vertebral formula 24-64-163 and pale median fins.

Immune complexome analysis reveals an autoimmune signature predictive of COVID-19 severity.

Background: The factors contributing to the development of severe coronavirus disease 2019 (COVID-19) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear. Although the presence of immune complexes (ICs), formed between antibodies and their antigens, has been linked to COVID-19 severity, their role requires further investigation, and the antigens within these ICs are yet to be characterized.

Method: Here, a C1q enzyme-liked immunosorbent assay and immune complexome analysis were used to determine IC concentrations and characterize IC antigens, respectively, in the sera of 64 unvaccinated COVID-19 patients with PCR-confirmed SARS-CoV-2 infection, enrolled at seven participating centers in 2020.

Association of Baseline Mitral Valve Area With Procedural and Clinical Outcomes of Mitral Transcatheter Edge-to-Edge Repair: Insights From the OCEAN-Mitral Registry.

Background: A small mitral valve area (MVA) is one of the challenging anatomies for transcatheter edge-to-edge repair (TEER) for mitral regurgitation, but the relationship between baseline MVA and clinical outcomes remains unknown. This study aimed to evaluate the association of baseline MVA with procedural and clinical outcomes in patients undergoing TEER with MitraClip from the OCEAN-Mitral registry (Optimized Catheter Valvular Intervention-Mitral).

Methods: A total of 1768 patients undergoing TEER were divided into 3 groups according to baseline MVA: group 1: <4.

A case of Erdheim-Chester disease-a mimicker of IgG4-related disease and large vessel vasculitis.

The patient was a 57-year-old man who developed bilateral thigh pain and chest tightness one year ago. Chest CT scan showed reticular shadows, thickened interlobular septa in both lung fields, and pericardial effusion. Three months ago, his symptoms worsened.

Is Sublobar Resection Feasible for High-Risk Pathologic Stage I Non-small Cell Lung Cancer?

Background: Sublobar resection is the standard procedure for cT1N0 stage I non-small cell lung cancer (NSCLC) size ≤2 cm. However, its efficacy for high-risk pathologic stage I cases with a preoperative diagnosis of cT1N0 stage I NSCLC size ≤2 cm remains unclear. This study compared the outcomes of sublobar resection with those of lobectomy from a pathologic perspective.

The effect of anticoagulation therapy on the surgical outcomes of minimally invasive major gastrointestinal surgery.

Background: The surgical outcomes of minimally invasive surgery (MIS) for gastrointestinal (GI) cancers in patients receiving anticoagulation therapy (ACT) are unknown. We investigated the effect of ACT on the surgical outcomes of minimally invasive major GI surgery, with a particular focus on postoperative bleeding and thromboembolic complications.

Methods: A total of consecutive 1290 patients undergoing elective minimally invasive (laparoscopic and robotic) major GI surgery (esophagogastric and colorectal resection for malignancy) between 2014 and 2023 were enrolled.

Effect of Anterior Disc Displacement and Estrogen Deficiency on Rabbit Mandibular Condyle.

Objective: In this study, we aimed to establish an experimental model of idiopathic condylar resorption by combining surgically induced anterior disc displacement and estrogen deficiency in growing rabbits. This study aimed to investigate the individual and combined effects of these factors on condylar resorption.

Materials And Methods: Seventeen female Japanese White rabbits were divided into four groups: control, ovariectomy, anterior disc displacement surgery, and combination of ovariectomy and anterior disc displacement surgery.

Coagulation-Targeted TGF-β Signaling Pathway Inhibitor Nanomedicine for Inhibiting the Growth and Lung Metastasis of Breast Cancer.

The transforming growth factor β (TGF-β) signaling pathway exerts a dual role in oncogenesis, acting as a suppressor in healthy and early stage neoplastic tissues while promoting malignancy and metastasis in advanced cancers. Tumor hemorrhage further exacerbates TGF-β-mediated metastasis by up-regulating its expression. Here, a coagulation-targeting peptide (A15)-decorated TGF-β inhibitor nanomedicine (A15-LY-NPs) was developed.

Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis.

The Japanese Society on Thrombosis and Hemostasis (JSTH) published the first-ever disseminated intravascular coagulation (DIC) guidelines in 2009. Fifteen years later, the JSTH developed new guidelines covering DIC associated with various underlying conditions. These guidelines were developed in accordance with the GRADE system to determine the strength of the recommendations and certainty of the evidence.

Paroxysmal delta waves of awake EEG in childhood adrenoleukodystrophy: Possible indicator of the hematopoietic stem cell therapy (HSCT).

Background: Childhood cerebral type of Adrenoleukodystrophy (CC-ALD) is fatal without hematopoietic stem cell transplantation (HSCT). We consider whether EEGs showing focal paroxysmal delta waves can be a candidate of early detector of the apparent ALD and HSCT therapy.

Methods: Twenty-two male children with ALD (5-16 years; 10.

Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 2: hematologic malignancy.

Disseminated intravascular coagulation (DIC) associated with hematologic malignancies, particularly acute promyelocytic leukemia (APL), is characterized by marked fibrinolytic activation, which leads to severe bleeding complications. Therefore, appropriate diagnosis and management of DIC are crucial for preventing bleeding-related mortality. However, to date, no clinical guidelines have specifically addressed hematologic malignancy-associated DIC.

Association of Lupus Low Disease Activity State And Remission With Reduced Organ Damage And Flare in Systemic lupus erythematosus Patients With High Disease Activity.

Objective: High disease activity status (HDAS) in patients with systemic lupus erythematosus (SLE) is associated with adverse long-term outcomes. We examined the frequency of lupus low disease activity state (LLDAS) and remission (REM) attainment in HDAS patients and whether their attainment was associated with improved patient outcomes.

Methods: Demographic, clinical and outcomes data, collected prospectively from a multinational cohort between 2013 and 2020, were analysed.

A Case of Uveitis and Hypothyroidism Following Pembrolizumab Therapy in a Patient With Plantar Malignant Melanoma.

Pembrolizumab is a PD-1 inhibitor that has improved survival in melanoma patients but can cause immune-related adverse events (irAEs) such as hypothyroidism and uveitis. Although these conditions rarely occur together, we present a case of a 54-year-old female with plantar malignant melanoma who developed hypothyroidism after the second cycle of pembrolizumab and then uveitis after the fifth cycle. Hypothyroidism was treated with levothyroxine, and uveitis was managed with corticosteroids.

Trends in endemic of respiratory syncytial virus infection during COVID-19 pandemic and difficulty in obtaining optimal timing of palivizumab prophylaxis.

Objective: The coronavirus disease (COVID-19) pandemic has affected the epidemiology of respiratory syncytial virus (RSV) infection. This study assessed whether or not palivizumab prophylaxis was appropriate during the COVID-19 pandemic.

Methods: This prospective study included children <24 months old who were hospitalized for RSV infection between April 2019 and March 2023.

Fractionated non-pulmonary vein triggers contribute to spontaneous activity and initiating and maintaining paroxysmal atrial fibrillation: A case report.

Unlabelled: Pulmonary vein (PV) antrum isolation (PVAI) that involves electrically isolating PV foci is a useful treatment strategy for atrial fibrillation (AF). However, non-PV triggers during/after the PVAI are observed in approximately 30 % of AF cases, contributing to AF recurrence. We present the case of an 84-year-old woman who underwent ablation of recurrent symptomatic paroxysmal AF in our hospital.

Hematogenous metastasis to the colon from hepatocellular carcinoma: A case report.

Introduction and importance: Most extrahepatic metastases of hepatocellular carcinoma (HCC) are to the lungs and bones, metastases to the colon are rare. In the present study, we experienced a case of metastasis to the ascending colon during repeated treatment for HCC. Case Presentation: A 63-year-old man was diagnosed with multiple HCCs (T4N0M0 stage IIIB) associated with portal vein invasion.

Self-reported symptoms or activity limitations and job loss during the COVID-19 pandemic in Japan.

Background: Previous studies have reported the impact of a diagnosed disease or self-perceived poor overall health on job loss. However, evidence is lacking on which self-reported symptoms or activity limitations are related to job loss, especially during the coronavirus disease 2019 (COVID-19) pandemic.

Aims: We investigated whether self-reported symptoms or activity limitations were correlated with the occurrence of job loss within 1 year during the COVID-19 pandemic.