Paroxysmal delta waves of awake EEG in childhood adrenoleukodystrophy: Possible indicator of the hematopoietic stem cell therapy (HSCT).

Background: Childhood cerebral type of Adrenoleukodystrophy (CC-ALD) is fatal without hematopoietic stem cell transplantation (HSCT). We consider whether EEGs showing focal paroxysmal delta waves can be a candidate of early detector of the apparent ALD and HSCT therapy.

Methods: Twenty-two male children with ALD (5-16 years; 10.

Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 2: hematologic malignancy.

Disseminated intravascular coagulation (DIC) associated with hematologic malignancies, particularly acute promyelocytic leukemia (APL), is characterized by marked fibrinolytic activation, which leads to severe bleeding complications. Therefore, appropriate diagnosis and management of DIC are crucial for preventing bleeding-related mortality. However, to date, no clinical guidelines have specifically addressed hematologic malignancy-associated DIC.

Association of Lupus Low Disease Activity State And Remission With Reduced Organ Damage And Flare in Systemic lupus erythematosus Patients With High Disease Activity.

Objective: High disease activity status (HDAS) in patients with systemic lupus erythematosus (SLE) is associated with adverse long-term outcomes. We examined the frequency of lupus low disease activity state (LLDAS) and remission (REM) attainment in HDAS patients and whether their attainment was associated with improved patient outcomes.

Methods: Demographic, clinical and outcomes data, collected prospectively from a multinational cohort between 2013 and 2020, were analysed.

A Case of Uveitis and Hypothyroidism Following Pembrolizumab Therapy in a Patient With Plantar Malignant Melanoma.

Pembrolizumab is a PD-1 inhibitor that has improved survival in melanoma patients but can cause immune-related adverse events (irAEs) such as hypothyroidism and uveitis. Although these conditions rarely occur together, we present a case of a 54-year-old female with plantar malignant melanoma who developed hypothyroidism after the second cycle of pembrolizumab and then uveitis after the fifth cycle. Hypothyroidism was treated with levothyroxine, and uveitis was managed with corticosteroids.

Trends in endemic of respiratory syncytial virus infection during COVID-19 pandemic and difficulty in obtaining optimal timing of palivizumab prophylaxis.

Objective: The coronavirus disease (COVID-19) pandemic has affected the epidemiology of respiratory syncytial virus (RSV) infection. This study assessed whether or not palivizumab prophylaxis was appropriate during the COVID-19 pandemic.

Methods: This prospective study included children <24 months old who were hospitalized for RSV infection between April 2019 and March 2023.

Fractionated non-pulmonary vein triggers contribute to spontaneous activity and initiating and maintaining paroxysmal atrial fibrillation: A case report.

Unlabelled: Pulmonary vein (PV) antrum isolation (PVAI) that involves electrically isolating PV foci is a useful treatment strategy for atrial fibrillation (AF). However, non-PV triggers during/after the PVAI are observed in approximately 30 % of AF cases, contributing to AF recurrence. We present the case of an 84-year-old woman who underwent ablation of recurrent symptomatic paroxysmal AF in our hospital.

Hematogenous metastasis to the colon from hepatocellular carcinoma: A case report.

Introduction and importance: Most extrahepatic metastases of hepatocellular carcinoma (HCC) are to the lungs and bones, metastases to the colon are rare. In the present study, we experienced a case of metastasis to the ascending colon during repeated treatment for HCC. Case Presentation: A 63-year-old man was diagnosed with multiple HCCs (T4N0M0 stage IIIB) associated with portal vein invasion.

Self-reported symptoms or activity limitations and job loss during the COVID-19 pandemic in Japan.

Background: Previous studies have reported the impact of a diagnosed disease or self-perceived poor overall health on job loss. However, evidence is lacking on which self-reported symptoms or activity limitations are related to job loss, especially during the coronavirus disease 2019 (COVID-19) pandemic.

Aims: We investigated whether self-reported symptoms or activity limitations were correlated with the occurrence of job loss within 1 year during the COVID-19 pandemic.

Laboratory markers predicting tofacitinib efficacy in Japanese patients with rheumatoid arthritis: A pooled analysis of Phase 2/3 randomised controlled clinical trials.

Objectives: We characterised early changes in laboratory parameters in Japanese patients with rheumatoid arthritis (RA) and assessed whether these changes at Month (M)1 were predictive of tofacitinib efficacy at M3.

Methods: This post hoc analysis included data from Japanese patients with RA receiving tofacitinib or placebo pooled from two Phase (P)2 studies in Japan (NCT00603512; NCT00687193) and one global P3 study (NCT00847613). Outcomes: changes from baseline in laboratory parameters (Week 2 and M1/3); efficacy endpoints (Disease Activity Score in 28 joints, based on C-reactive protein [DAS28-4(CRP)], DAS28-4, based on erythrocyte sedimentation rate [DAS28-4(ESR)], and American College of Rheumatology-N index) at M3.

An autopsy of a patient with polyarteritis nodosa who developed fatal intestinal perforation accompanied by systemic multiple aneurysms and arterial thrombosis.

The patient was a 48-year-old man who had developed acute myocardial infarction 3 years earlier. He started experiencing recurrent attacks of abdominal pain 2 years earlier. One month before the presentation, he developed perforative peritonitis, which was treated with right hemicolectomy.

A rare case of oropharyngeal metastasis from lung adenocarcinoma.

Oropharyngeal metastasis from other organs is rare, especially from lung cancer. However, in lung cancer cases, the oropharynx should be considered a potential site for distant spread.

Revised method for preparation of simulated body fluid for assessment of the apatite-forming ability of bioactive materials: proposal of mixing two stock solutions.

Bioactive glasses and glass-ceramics exhibit osteoconductivity, which is the ability to form a direct bond with living bone tissue. This property is typically assessed by observing the formation of a hydroxyapatite layer using simulated body fluid (SBF), a solution designed to mimic the inorganic constituents of human blood plasma. SBF was developed by Kokubo (T.

Prosthetic Gait Achievement in an Elderly Patient with Chronic Limb-threatening Ischemia and High Complications Using a Novel Lipoprotein Apheresis.

Background: Chronic limb-threatening ischemia is a condition of the lower extremities that requires therapeutic intervention. It is characterized by ischemia, tissue loss, neuropathy, infection, and risk of amputation.

Case: An 82-year-old woman with a history of bilateral total knee arthroplasty and rheumatoid arthritis underwent a left ankle arthroplasty.

Pacing-Induced Cardiomyopathy in a Patient With a Leadless Pacemaker Following Transcatheter Aortic Valve Replacement.

Conduction disturbances following transcatheter aortic valve replacement (TAVR) sometimes require permanent pacemaker implantation. However, little is known about the pacing-induced cardiomyopathy (PICM) in leadless pacemaker (LP) after TAVR. Here we present a case of heart failure due to PICM 6 months after TAVR which was successfully treated with LOT-CRT upgrade.

Morphology of the egg-case and larva of Paracymus aeneus (Germar) (Coleoptera: Hydrophilidae).

The generic and species identity of previously described larva of Paracymus aeneus (Germar, 1824), the type species of the genus Paracymus Thomson, 1867, has been a subject of controversy owing to their morphological similarity to the genus Anacaena Thomson, 1859. In this study, we describe morphology of the egg-case and all three instar larvae of P. aeneus based on Japanese specimens obtained through rearing and provide the biological information on the species under rearing conditions.

Differentiation-inducing factor-1 inhibits EMT by proteasomal degradation of TAZ and YAP in cervical and colon cancer cell lines.

We previously reported differentiation-inducing factor-1 (DIF-1) activated glycogen synthase kinase-3 (GSK-3) in various mammalian cells. GSK-3 has been proposed to regulate a number of signaling pathway including TAZ/YAP signaling pathway. To clarify the effect of DIF-1 on TAZ/YAP signaling pathway, we examined whether DIF-1 affect the expression levels of TAZ and YAP.

Secondary Revision after Breast Reconstruction with Free Abdominal Perforator Flap: Flap Liposuction and Inframammary Fold Reconstruction.

Background: In breast reconstruction using the abdominal perforator flap, if the flap capacity is too large, secondary revision procedures can be performed to reduce flap volume and reconstruct the inframammary fold (IMF). We examined the various revision methods and cosmetic results.

Methods: This study included 28 patients who underwent secondary revision among 216 patients who had breast reconstruction using the abdominal perforator flap between April 2012 and March 2019.

A bio-nano-engineered platform fabricated from cerium oxide-carbon nanoparticles stabilized with chitosan for label-free sensing of a lung cancer biomarker.

Herein, we report a label-free cancer biosensor designed for carcinoembryonic antigen (CEA) detection using a nanohybrid comprising CeO nanoparticles, carbon nanoparticles (CNPs), and chitosan (Ch). CeO nanoparticles were prepared using a simple green synthesis process. A thin film of the CeO-CNPs-Ch nanohybrid was formed on indium tin oxide (ITO)-coated glass plates that endowed a high surface area, excellent stability, and good adsorption for the efficient loading of CEA antibodies.

Clinical expert consensus document on bailout algorithms for complications in percutaneous coronary intervention from the Japanese Association of Cardiovascular Intervention and Therapeutics.

The efficacy and safety of percutaneous coronary intervention (PCI) for coronary artery disease has been established, and approximately 250,000 PCI procedures are performed annually in Japan. However, various complications including life-threatening complications can occur during PCI. Although several bailout procedures have been proposed to address complications during PCI, it is critically important for operators to manage each complication in real catheter rooms with confidence even in emergent situations.