Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia.

Relationship between interleukin-10 (IL-10) gene G-1082A (rs1800896) polymorphism and the risk of development and stages of chronic lymphoid leukemia is studied in ethnic Russian residents of the Kirov region of Russia. Associations of allele -1082A and genotypes (-1082AA/-1082AG) with the risk of chronic lymphoid leukemia are detected (OR=1.39, 95%CI=1.

Adjuvant effect of high-frequency hyperthermia of the abdominal cavity on the course of transplanted leukemia in AKR mice.

The adjuvant effect of high-frequency hyperthermia of the abdominal cavity was studied in 2-month-old mice of highly leukemic AKR strain treated with cyclophosphamide. Weights of organs, parameters of the peripheral blood, and cytological imprints of organs were compared in experimental and control animals. A more pronounced antitumor effect was observed in animals exposed to hyperthermia.