Anticancer potential of decursin, decursinol angelate, and decursinol from Nakai: A comprehensive review and future therapeutic prospects.

Many naturally derived compounds are currently used in oncotherapy. Besides official medicine, complementary and alternative medicine practices, including old herbal remedies, are widely used and accepted as additional tools in cancer treatment. Nakai (AGN), a medicinal herb in Asia, has roots historically used in medicine.

Anti-anemic potential of L. in iron-deficient rat model; network pharmacology profiling.

Iron deficiency anemia is a global health concern, affecting around 2 billion people. Oral iron therapy often causes severe gastro-intestinal issues. , member of the Brassicaceae family, is valued in traditional medicine and renowned for its rich iron and vitamin C content.

Bioactive Potential of the Sulfated Exopolysaccharides From the Brown Microalga sp.: Antioxidant, Antimicrobial, and Antiapoptotic Profiles.

This study aims to investigate the physicochemical characteristics of the exopolysaccharides (EPS) extracted from the microalgae species sp., as well as to evaluate their antioxidant, antibacterial, and anti-apoptotic activities. The crude extracellular polysaccharides from the halophilic diatom sp.

Functionalized porous carbon microspheres packed column for solid phase extraction and preconcentration of trace metal ions in food and water samples.

Porous materials play a crucial role in the extraction of trace analytes; yet, the attainment of high selectivity and efficient regeneration continues to pose a considerable problem. In this study, we employed a green method to synthesize porous carbon microspheres. These microspheres were subsequently functionalized with aminophosphonic acid to facilitate the extraction of heavy metal ions from real samples.

A simple and cost-effective hybrid stationary phase for the separation of peptides, proteins and benzene derivatives through liquid chromatography.

A very simple and cost-effective silica-based hybrid stationary phase was synthesized for the separation of five synthetic peptides, five proteins, and benzene derivatives. Silica monolith was synthesized sol-gel process. Particles obtained through the grinding of silica monolith were suspended in methanol and sedimented under gravity to obtain sub-2 μm particles.

Sol-gel derived ceramic nanocomposite CNFs anchored with a nanostructured CeO modified graphite electrode for monitoring the interaction of a selective tyrosine kinase inhibitor capmatinib with dsDNA.

In the current study, the potential interaction mechanisms between capmatinib (CAP), a selective tyrosine kinase inhibitor, and calf thymus double-stranded DNA (ds-DNA) were evaluated. In this research, we construct an amplified electrochemical platform based on a disposable pencil graphite electrode (PGE) modified with nanostructured CeO decorated carbon nanofiber ceramic film (CeNPs@CNF-CF) for monitoring CAP-dsDNA interaction at physiological pH. The morphology and structure of the obtained CeNPs@CNF nanocomposite were characterized.

Mechanistic insights into carbonic anhydrase IX inhibition by coumarins from : and approaches.

Given the critical role of carbonic anhydrase IX (CA IX) in various pathological conditions, there is a significant demand for new inhibitors to enhance patient outcomes and clinical management. In this study, we examined the inhibitory effectiveness of five coumarins derived from against CA IX using assays and computational modeling. Among the coumarins tested, xeroboside and isobaisseoside were identified as the most potent inhibitors.

Optical detection of uric acid based on a citric acid functionalized copper-doped biochar nanozyme.

Uric acid is the end product of purine metabolism and is a key biomarker for various diseases. Under normal conditions, there is a balance between its production and excretion. Its higher concentration can cause inflammation and severe pain, which makes it necessary to monitor its level for the diagnosis, management, and treatment of various pathological conditions.

2D-based electrode materials for supercapacitors - status, challenges, and prospects.

The pursuit of efficient and sustainable energy storage solutions has fueled significant interest in the development of advanced materials for supercapacitors. Among these, two-dimensional (2D) materials undoubtingly have emerged as promising candidates due to their unique structural and electrochemical properties. To address the inherent challenges such as restacking, limited ion-accessibility, limited scalability, stability under operational conditions, and the intricate balance between surface area and conductivity that hinder the practical application of 2D materials, this article delves into innovative approaches and emerging strategies and prospects that aim to enhance their performance and durability.

Zinc oxide/tin oxide nanoflower-based asymmetric supercapacitors for enhanced energy storage devices.

Research on energy storage devices has focused on improving asymmetric supercapacitors (ASCs) by utilizing two different electrode materials. In this work, we have successfully prepared a unique material, ZnO/SnO nanoflower, the hydrothermal method. Graphene oxide (GO) was synthesized by applying the modified Hummers' technique.

Synergistic charge-transfer dynamics of novel pyridoquinazolindone-containing triphenylamine-based push-pull chromophores: from structural optimization to performance metrics in photovoltaic solar cells and static, dynamic, solvent-dependent nonlinear optical response applications.

Modern technological breakthroughs depend on nonlinear optical (NLO) and photovoltaic (PV) materials, essential for creating advanced photonic devices and efficient solar cells. Herein, the NLO, PV, electrical, and photophysical characteristics of proposed chromophores (WLK-1-WLK-6) designed from pyridoquinazolindone-containing triphenylamine have been systematically altered by the addition of different spacers categorized as K1, K2, K3, K4, K5, and K6 (named as i-series). This fine-tuning was accomplished using TD-DFT, DFT computations, and the Scharber model.

N, S-codoped carbon dots for antioxidants and their nanovehicle potential as molecular cargoes.

This work demonstrates the facile one step hydrothermal synthesis of carbon dots doped with nitrogen and sulfur (SCDs). The carbon dots have various uses, including their use as molecular payloads for antioxidant and drug delivery purposes. The sizes of the CDs were determined using transmission electron microscopy (TEM), which revealed an average size of 4.

Development and optimization of a sustainable polyoxometalate-kaolinite-based catalyst for efficient desulfurization of model and real fuel using Box-Behnken design.

The oxidative desulfurization of dibenzothiophene in model and real fuel has been investigated by developing an environmentally sustainable catalyst HSiWO@f-kaolinite. The catalyst was synthesized by modifying kaolinite clay with (3-aminopropyl)triethoxysilane (f-kaolinite) followed by immobilizing silicotungstic acid hydrate (HSiWO) onto its surface. The successful synthesis of the catalyst was characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, UV-visible spectroscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, and scanning electron microscopy.

A Novel Endoscopic Anterior Cricoid Rib Grafting: A Feasibility Study in An Animal Model.

Objective: The objective of our study was to document the feasibility of a novel endoscopic anterior cricoid split and rib grafting technique in a goat airway model.

Study Design: Feasibility pilot animal study.

Setting: Animal surgical laboratory at a tertiary hospital and research center.

Theoretical investigation of benzodithiophene-based donor molecules in organic solar cells: from structural optimization to performance metrics.

Achieving high power conversion efficiency (PCE) remains a significant challenge in the advancement of organic solar cells (OSCs). In the field of organic photovoltaics (OPVs), considerable progress has been made in optimizing molecular structures to improve the PCE. However, innovative material design strategies specifically aimed at enhancing PCE are still needed.

Effect of different blanching methods on kinetics of physico-chemical, functional properties, and enzyme inactivation in baby corn.

Baby corn, characterized by its high water activity and elevated respiration rate, poses a formidable obstacle to prolonged storage under standard ambient conditions and necessitates specialized treatments for transportation to distant locations. One of the primary postharvest challenges associated with baby corn is the occurrence of brown pigment formation because of enzymatic browning at the apex of its immature ovules, cut surfaces, and silk attached to the young ears. The present study was undertaken to investigate the effect of different blanching treatments on peroxidase inactivation, physicochemical properties, and functional properties of baby corn.

Species groups, subgroups, and key to world species of the genus Trägårdh, 1915 (Acari, Prostigmata, Tetranychidae).

After a comprehensive taxonomic assessment of descriptions/ illustrations of all known (118) species of the spider mite genus Trägårdh (Acari: Prostigmata: Tetranychidae), five species groups are proposed based on the number of tactile setae on tibia II in female, i.e., with four setae (four spp.

Microbially mediated phenolic catabolites exert differential genoprotective activities in normal and adenocarcinoma cell lines.

Age-associated decline of nuclear factor erythroid 2-related factor 2 (Nrf2) activity and DNA repair efficiency leads to the accumulation of DNA damage and increased risk of cancer. Understanding the mechanisms behind increased levels of damaged DNA is crucial for developing interventions to mitigate age-related cancer risk. Associated with various health benefits, (poly)phenols and their microbially mediated phenolic catabolites represent a potential means to reduce DNA damage.

Synthesis, kinetics, mechanisms, and bioactivity evaluations of a novel Zn(ii) complex.

Zn(ii)-based anticancer drugs can be suitable alternatives to conventional Pt(ii)-based drugs because of the unique chemical properties of Zn(ii) and low toxicity. In this study, a new hexadentate and heteroleptic Zn(ii) complex ([Zn(bpy)(OAc)], 1) was prepared with a conventional ,-donor ligand (2,2'-bipyridine) and a leaving group (OAc) and characterized ESI-MS, UV-Vis, and FT-IR spectroscopy. Kinetic and mechanistic investigations of 1 were performed using two biologically relevant ligands (dl-penicillamine and l-cysteine) to understand its selectivity and reactivity.