Echocardiographic Evaluation in Cardiac Resynchronization Therapy: A Single Center Experience.

Introduction Heart failure develops as a result of dysfunction in the cardiac muscle, which impairs the heart's ability to pump blood effectively. For this reason, many studies have shown that cardiac resynchronization therapy (CRT) has significantly reduced symptoms and improved cardiac function in patients with heart failure. Echocardiography is crucial in assessing CRT response, as it helps differentiate between patients who benefit from CRT and those who do not by evaluating key parameters like left ventricular ejection fraction (LVEF), a critical parameter in determining CRT eligibility.

School Teachers' Knowledge and Attitudes Related to Anaphylactic Reactions: A Cross-Sectional Study.

Introduction: Anaphylaxis is a severe allergic reaction marked by a sudden onset of symptoms affecting multiple bodily systems, and if not addressed promptly, it can lead to fatal outcomes. The primary clinical manifestations often involve skin rash, respiratory distress, and cardiovascular symptoms. Identifying these signs early is crucial for timely intervention, including the administration of epinephrine, aiming to prevent loss of life.

Rising Cesarean Section Rates in Pakistan: Analyzing Frequency and Key Risk Factors in a Tertiary-Care Hospital.

The increasing frequency of cesarean sections (CS) has emerged as a significant public health concern, particularly in Pakistan. This cross-sectional study aimed to assess the prevalence of CS and its contributing factors among mothers in an underdeveloped region of the country. Data were collected from 250 delivery cases using a self-developed questionnaire.

Preliminary findings on the absence of PEPITEM release in B cells isolated from Saudi donors: implications for expanded population studies.

Background: Adiponectin (AQ) plays a role in regulating immune responses. Previous research indicates that B cells can affect T cell transmigration via the adiponectin-induced peptide PEPITEM in Caucasians. This study explores whether this mechanism is also applicable to Saudi populations, considering potential ethnic variations in immune response.

Descriptive analysis of incidence, demographic characteristics, and survival outcomes of soft-tissue sarcoma of the extremities in Saudi Arabia.

Soft-tissue sarcomas are uncommon, aggressive, and histologically heterogeneous, malignant tumors. Soft-tissue tumor types have different age and anatomical site distributions. This study aimed to assess the prevalence and incidence of soft-tissue sarcomas of the extremities to facilitate early diagnosis and intervention in the Kingdom of Saudi Arabia.

Two-Month Duration of Esophageal Button Battery Impaction in a 23-Month-Old Boy: A Case Report.

Ingestion of foreign bodies, particularly button batteries (BB), is a common pediatric emergency. Esophageal impaction of BB is associated with life-threatening complications. Damage can be manifested within hours from ingestion; therefore, immediate removal is recommended.

Protecting optimal childhood growth: systematic nutritional screening, assessment, and intervention for children at risk of malnutrition in the Kingdom of Saudi Arabia.

Background: In 2024, the Kingdom of Saudi Arabia Advisory Board on Pediatric Nutrition (KSA-ABPN) reviewed childhood undernutrition in the Middle East. We sought to foster efficient nutritional care for infants and children at nutritional risk. Severe malnutrition due to starvation is rare in Saudi Arabia, so we focused on early recognition and treatment of children with mild growth impairment that forewarns risk for further nutritional decline.

Leveraging machine learning in limited sampling strategies for efficient estimation of the area under the curve in pharmacokinetic analysis: a review.

Objective: Limited sampling strategies are widely employed in clinical practice to minimize the number of blood samples required for the accurate area under the curve calculations, as obtaining these samples can be costly and challenging. Traditionally, the maximum a posteriori Bayesian estimation has been the standard method for the area under the curve estimation based on limited samples. However, machine learning is emerging as a promising alternative for this purpose.

Huge Atypical Meningioma in a 21-Month-Old Girl: A Case Report.

Meningiomas are the most common intracranial tumors, but it's uncommon in the pediatric and adolescent populations. Pediatric meningiomas differ from adult meningiomas by a higher rate of malignant change, atypical location, male predominance and a higher recurrence rate. The most common presenting symptoms in supratentorial pediatric meningiomas are the signs and symptoms of high intracranial pressure (headache, vomiting, and nausea) and seizures.

Advanced Cardiac Point-of-Care Ultrasound: A Systematic Review of Select Cardiac Diseases.

Basic cardiac point-of-care ultrasound (POCUS)/focused cardiac ultrasound (FoCUS) often reveals incidental findings. Consider a patient with dyspnea in whom FoCUS reveals left ventricular (LV) hypertrophy, calcified valves, and pericardial effusion but "normal" LV systolic function. Such findings may trigger comprehensive echocardiography.

Gender differences in burnout among US nurse leaders during COVID-19 pandemic: an online cross-sectional survey study.

Objectives: Among nurse leaders, gender should receive particular attention, because life and work experiences and burnout during COVID-19 pandemic may vary between women and men, potentially requiring different strategies to achieve well-being. Thus, information about gender differences in burnout might be critical to burnout prevention in nurse leaders. Additionally, there has been a substantial call for attention to gender during the COVID-19 pandemic, reflecting a concern that responses to the pandemic that fail to consider gender differences and norms will be ineffective.

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections.

Background: Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain.

Methods: In a multicenter, noninferiority trial, we randomly assigned hospitalized patients (including patients in the intensive care unit [ICU]) who had bloodstream infection to receive antibiotic treatment for 7 days or 14 days.

Adherence to Treatment Guidelines Among Patients With Type 2 Diabetes Attending a Tertiary Hospital in Jeddah, Saudi Arabia.

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that is associated with many complications if untreated. Guidelines, including those from the American Diabetes Association (ADA), are published regularly to enhance the management of diabetes in all aspects of care including regular screening of diabetic complications and encouraging the use of newer medications such as sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1a). This study aims to assess the adherence to ADA guidelines at a tertiary care center in Saudi Arabia.

Conservative Management of Facial Talon Cusp in a Permanent Maxillary Central Incisor: A Case Report.

Facial talon cusp is a rare developmental dental anomaly with unknown etiology. This case report is about an 11-year-old boy who presented with discomfort associated with tooth #11. After clinical and radiographical examination, the diagnosis of facial talon cusp (stage 1) was established.

Association of Pediatric Gastroesophageal Reflux Disease and Subglottic Stenosis: A Systematic Review and Meta-analysis.

Gastroesophageal reflux disease in children, which affects approximately 18% of infants, results from gastric contents flowing into the esophagus due to factors such as immature sphincter function. Regurgitation is normal and often resolves by age two; however, persistent gastroesophageal reflux disease can lead to otolaryngological lesions such as subglottic stenosis. PubMed, AIRE, Scholar, MEDLINE, Springer Nature Journal, and Scopus were searched from their inception to February 2024.

Minimizing Blood Loss Using Tranexamic Acid in Patients Undergoing Liposuction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Liposuction has become the most sought-after aesthetic surgery across the globe, increasing the demand for more developments in patient safety protocols. Evidence of the efficacy of tranexamic acid (TXA) in reducing intraoperative blood loss with minimal complications have led to its widespread applications across various surgical operations. However, the role and effectiveness of TXA in liposuction is not fully understood.

Thromboelastography for rapid diagnosis of heparin-like anticoagulant release during anaphylaxis-induced coagulopathy in systemic mastocytosis: a case report.

Anaphylaxis can induce life-threatening coagulopathy by releasing various mediators from activated mast cells. These mediators directly affect coagulation and fibrinolytic pathways, increasing the bleeding risk. Diagnosis and management of anaphylaxis-induced coagulopathy remain challenging.

Total Thyroidectomy Versus Partial Thyroidectomy for Non-Toxic Multinodular Goiter: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Unlabelled: Thyroid follicular nodular disease (non-toxic multinodular goiter), the commonest thyroid disorder, can be managed with different surgical methods, including total thyroidectomy (TT), near-total thyroidectomy (NTT), subtotal thyroidectomy (STT), and Dunhill operation (DO). This systematic review and meta-analysis aimed to provide an update on the role of TT versus NTT, STT, or DO in MNG concerning goiter recurrence, thyroid cancer incidence, and reported complications. We conducted a systematic literature search in Medline, EMBASE, and CENTRAL.

A rare case of hepatocellular carcinoma and colorectal liver metastasis.

Hepatocellular carcinoma is the third leading cause of cancer deaths worldwide, with a 5-year survival rate of 20.3%, while colorectal cancer is a major cause of morbidity and mortality worldwide, being the third most common cancer in men and the second in women. In addition, multiple primary tumors, involving cancers at different sites and histologies, occur in 2.