1 results match your criteria: "King Saud Bin Abdul Aziz University for Medical Sciences (KSAU-HS)[Affiliation]"
Human decidua basalis mesenchymal stem/stromal cells enhance anticancer properties of human natural killer cells, .
Front Cell Dev Biol
October 2024
Stem Cells and Regenerative Medicine Unit, Blood and Cancer Research Department, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdul Aziz University for Medical Sciences (KSAU-HS), King Abdulaziz Medical City (KAMC), Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia.
Article Synopsis
- DBMSCs from the human placenta show potential as candidates for cellular therapy due to their ability to modulate the functions of natural killer (NK) cells.
- Co-culturing DBMSCs with NK cells inhibited the proliferation of resting NK cells while increasing that of IL-2 activated NK cells, indicating a complex interaction between the two cell types.
- Despite DBMSCs expressing HLA class I molecules, NK cells could still lyse them, which suggests that DBMSCs can enhance NK cell anticancer activities, potentially improving future therapeutic strategies.