Ultrasound-assisted synthesis of novel 2-aryl-3-ethoxy-5-methyl-3-oxido-2-thiazolo[2,3-][1,4,2]diazaphosphole-6-carboxylates and their anticancer efficacy in inducing apoptosis and autophagy and targeting cell cycle progression.

A novel class of ethyl 2-aryl-3-ethoxy-5-methyl-3-oxido-2-thiazolo[2,3-][1,4,2]diazaphosphole-6-carboxylates (2a-j) were synthesized a one-pot, three-component method. This reaction utilized ethyl 2-amino-4-methylthiazole-5-carboxylate (1) with different aromatic aldehydes and ethyl dichlorophosphite in THF under ultrasonic irradiation, with triethylamine as an efficient catalyst at 50 °C. The reaction provided the desired products 2a-j in high yields within a short timeframe.