Orthodontic Space Management in Pediatric Dentistry: A Clinical Review.

The mixed dentition stage is a vital period characterized by significant physiological changes, including jaw growth, the development and eruption of permanent teeth, the exfoliation of primary teeth, and the maturation of surrounding soft tissues. These processes collectively ensure functional, esthetic, and stable occlusion. Disruptions during this stage, such as the premature loss of deciduous teeth, can lead to spacing or crowding issues and affect the dental arch length and the position of permanent teeth.

The Pharmacological Management of Essential Tremor and Its Long-Term Effects on Patient Quality of Life: A Systematic Review.

Essential tremor (ET) is one of the most prevalent nerve-related movement disorders, most commonly affecting the hands during voluntary movements or while maintaining posture. Unlike tremors in neurodegenerative conditions, ET is not observed at rest. Continued research is essential to optimize treatment strategies and address the unmet need for sustainable, patient-centered therapies that minimize side effects and enhance long-term quality of life (QoL) for individuals with ET.

AI-optimized electrochemical aptasensors for stable, reproducible detection of neurodegenerative diseases, cancer, and coronavirus.

AI-optimized electrochemical aptasensors are transforming diagnostic testing by offering high sensitivity, selectivity, and rapid response times. Leveraging data-driven AI techniques, these sensors provide a non-invasive, cost-effective alternative to traditional methods, with applications in detecting molecular biomarkers for neurodegenerative diseases, cancer, and coronavirus. The performance metrics outlined in the comparative table illustrate the significant advancements enabled by AI integration.

Global distribution and sustainable management of Asian corn borer (ACB), (Lepidoptera: Crambidae): recent advancement and future prospects.

The Asian corn borer (ACB), (Guenée, 1854), is a serious pest of several crops, particularly a destructive pest of maize and other cereals throughout most of Asia, including China, the Philippines, Indonesia, Malaysia, Thailand, Sri Lanka, India, Bangladesh, Japan, Korea, Vietnam, Laos, Myanmar, Afghanistan, Pakistan and Cambodia. It has long been known as a pest in South-east Asia and has invaded other parts of Asia, Solomon Islands, parts of Africa and certain regions of Australia and Russia. Consequently, worldwide efforts have been increased to ensure new control strategies for management.

Association between cognitive restraint, emotional eating, uncontrolled eating, and body mass index among health care professionals.

Among healthcare professionals (HCPs), the demanding nature of their work, irregular schedules, and high-stress environments can significantly influence their eating behaviors. This study's objectives were to assess the relationship between cognitive restraint (CR), emotional eating (EE), uncontrolled eating (UE), and body mass index (BMI) and identify the sociodemographic factors associated with CR, EE, and UE among HCPs. A cross-sectional study and a simple random sampling technique were employed.

Epigallocatechin 3-gallate-induced neuroprotection in neurodegenerative diseases: molecular mechanisms and clinical insights.

Neurodegenerative diseases (NDs) are caused by progressive neuronal death and cognitive decline. Epigallocatechin 3-gallate (EGCG) is a polyphenolic molecule in green tea as a neuroprotective agent. This review evaluates the therapeutic effects of EGCG and explores the molecular mechanisms that show its neuroprotective properties.

Impact of water stress to plant epigenetic mechanisms in stress and adaptation.

Water is the basic molecule in living beings, and it has a major impact on vital processes. Plants are sessile organisms with a sophisticated regulatory network that regulates how resources are distributed between developmental and adaptation processes. Drought-stressed plants can change their survival strategies to adapt to this unfavorable situation.

OpenAI's Sora and Google's Veo 2 in Action: A Narrative Review of Artificial Intelligence-driven Video Generation Models Transforming Healthcare.

The rapid evolution of generative artificial intelligence (AI) has introduced transformative technologies across various domains, with text-to-video (T2V) generation models emerging as transformative innovations in the field. This narrative review explores the potential of T2V AI generation models used in healthcare, focusing on their applications, challenges, and future directions. Advanced T2V platforms, such as Sora Turbo (OpenAI, Inc.

Enhancing soybean germination and vigor under water stress: the efficacy of bio-priming with sodium carboxymethyl cellulose and gum arabic.

Seed priming can significantly enhance the tolerance of soybean against different environmental stresses by improving seed water uptake and modulating stress-response mechanisms. In particular, seed priming with sodium carboxymethylcellulose (SCMC) and gum Arabic (GA) can support seeds to withstand extreme conditions better, promoting more consistent germination and robust seedling establishment, which is crucial for achieving stable agricultural yields. The present study investigated the effects of seed priming using a combination of SCMC and GA (10% CG) on the germination, growth, and biochemical responses of six soybean varieties under drought and flooding stress conditions.

The Impact of Idiopathic Intracranial Hypertension on Cardiovascular Disease Risk Among UK Women: An Obesity-Adjusted Analysis.

Introduction: Idiopathic intracranial hypertension (IIH) is known to elevate cardiovascular disease (CVD) risk, but the extent to which obesity and IIH-specific factors contribute to this risk is not well understood. WE aim to separate the effects of obesity from IIH-specific factors on the risk of stroke and CVD, building on previous findings that indicate a two-fold increase in cardiovascular events in women with IIH compared to BMI-matched controls.

Methods: An obesity-adjusted risk analysis was conducted using Indirect Standardization based on data from a cohort study by Adderley et al.

Identifying Potential Autophagy Modulators in Panch Phoron Spices (P5S): An In Silico approach.

Despite recent breakthroughs in diagnosis and treatment, cancer remains a worldwide health challenge with high mortality. Autophagy plays a major role in the progression and development. Starving cancer cells obtain nutrients through the upregulation of autophagy.

Primary Dentin Conditioning with Methylene Blue Activated Photodynamic Therapy, Phytic Acid, and Er,Cr:YSGG to Resin-Modified Glass Ionomer Cement in Comparison to Conventional Polyacrylic Acid.

Impact of surface conditioner phytic acid (IP6) Er,Cr:YSGG laser (ECYL) methylene blue photodynamic therapy (MB-PDT) on the microleakage and shear bond strength (SBS) of resin-modified glass ionomer cement (RMGIC) to primary sound dentin. Overall, 80 extracted sound primary molars were collected followed by their submergence in self-cure acrylic resin. The dentin surface was exposed and made flat and was assigned into four groups based on the surface conditioning.

Cytotoxicity of Nanocarrier-Based Drug Delivery in Oral Cancer Therapy: A Systematic Review and Meta-Analysis.

Background: Oral cancer remains 1 of the biggest health care challenges; it has a poor response to treatment, and treatment often results in severe side effects. Nano-targeted drug carrier-assisted drug delivery systems can improve the benefits of targeted drug delivery and treatment efficacy. A systematic review and meta-analysis was conducted to investigate the effect of targeted nano carrier drug delivery systems on the management of oral cancer.

An examination of ankle joint position sense, postural control and associated neuromuscular deficits in patients with plantar fasciitis: a cross-sectional analysis with advanced biomechanical and psychosocial correlates.

Background: Ankle joint position sense (AJPS) accuracy and postural control are crucial for maintaining balance and stability, particularly in individuals with plantar fasciitis who may experience proprioceptive and functional impairments. Understanding how psychosocial factors, such as pain catastrophizing, and biomechanical measures, like muscle strength and gait parameters related to proprioception and postural control, can inform more effective treatment approaches. This study aimed to (1) examine the relationship between AJPS accuracy and biomechanical factors-including postural stability, lower limb muscle strength, and gait parameters-in individuals with plantar fasciitis d (2) analyze the impact of psychosocial factors, including pain catastrophizing, physical activity level, and quality of life, on AJPS accuracy and postural control in this population.

Efficient IP address retrieval using a novel octet based encoding technique for high speed lookup to improve network performance.

As the Internet becomes increasingly popular, the number of users connected to it grows significantly. Consequently, the packet processing speed of network systems, such as routers, must be enhanced. IP lookup is a critical task used to find the next hop address by searching for the longest prefix match in the forwarding information base (FIB).

Non-coding RNAs in urinary bladder cancer microenvironment: Diagnostic, therapeutic, and prognostic perspective.

Urinary bladder cancer (UBC) is the ninth most common cancer worldwide. Despite the reliance of UBC therapy on definite pathological grading and classifications, the clinical response among patients varies widely. The molecular basis of this type of cancer appeals to considerable research; hence, new diagnostic and therapeutic options are introduced.

Migraine among King Khaled University students; prevalence, determinants, and impact on academic life.

Background: Migraine is a common primary headache disorder that significantly affects academic life and is often associated with stress, depression, anxiety, and irregular sleep patterns among university students. This study aimed to assess the prevalence of migraine among King Khalid University (KKU) students, identify its determinants, and evaluate the impact of migraine and other headaches on academic life and performance.

Methods: An analytical cross-sectional study was conducted among 732 students from Colleges of Medicine, Pharmacy, Engineering, and Computer science.

Design and synthesis of new 1,2,3-triazole derivatives as VEGFR-2/telomerase downregulatory candidates endowed with apoptotic potential for cancer treatment.

In this current work, we dedicated efforts to designing and synthesizing new 1,2,3-triazole-analogues (5a-d), (6a-d), and (7a-c) to act as dual VEGFR-2 and telomerase inhibitors with promising apoptotic potential. The synthesized analogues were examined against eleven diverse types of cancer cells and two normal cells to assess their ability to inhibit cell growth (GI%). Obviously, compound 7b showed the best average GI% (75.

Economic impact and clinical benefits of clinical pharmacy interventions: A six-year multi-center study using an innovative medication management tool.

Background: Increasing healthcare costs, particularly in Low- and Middle-Income Countries (LMICs) like Egypt, highlight the need for rational economic strategies. Clinical pharmacy interventions offer potential benefits by reducing drug therapy problems and associated costs, thereby supporting healthcare system sustainability.

Objective: This study evaluates the economic impact and clinical benefits of clinical pharmacy interventions in four tertiary hospitals in Egypt by implementing an innovative tool for medication management, focusing on cost avoidance and return on investment (ROI), while accounting for case severity and drug therapy problem (DTP) resolution.

Synthesis and modification of novel thiazole-fused quinoxalines as new insecticidal agents against the cotton leafworm : design, characterization, bio-evaluation, toxicological effectiveness, and study their mode of action.

Herein, novel thiazolo[4,5-]quinoxalin-2-ones 2-6 and thiazolo[4,5-]quinoxalin-2(3)-imines 7-9 were synthesized and characterized using elemental analysis, IR spectroscopy, and H/C NMR to confirm their structures. The efficacy of the newly designed thiazolo-quinoxalines 2, 3, 4, 5, 7, 8, and 9 against the cotton leafworm (2nd and 4th instar larvae) was evaluated, and results revealed insecticidal activity with variable and good mortality percentages. A SAR study was also discussed.

Non-adherence to Clinical Practice Guidelines in Regional Anesthesia and Pain Interventions: Insights From a Comprehensive Case Series Review.

Adhering to established guidelines, regional anesthesia (RA) and pain interventions are essential for preventing or minimizing the risk of complications. This study examines neurological complications that may arise when RA or pain interventions are performed without adherence to the clinical practice guidelines. This article aimed to emphasize the relationship between deviations from standards of care in RA and neurological outcomes.

Creutzfeldt-Jakob Disease in a Saudi Female: A Case Report.

Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive, and incurable neurodegenerative disorder caused by prions. It is invariably fatal and classified under transmissible spongiform encephalopathies. This case report presents a 66-year-old Saudi female who was admitted to the neurology department due to a rapidly advancing cognitive decline.

Unusual Presentation of Papillary Thyroid Carcinoma as a Lateral Neck Cystic Mass: A Case Report.

Papillary thyroid cancer (PTC) is the most frequent thyroid malignancy. Recently, the incidence has become widespread among both male and female individuals worldwide. In this article, we aim to report a 32-year-old Saudi female who presented with a painless lateral neck mass for more than seven months, and on excisional biopsy, was found to have features of PTC.

Combined application of methyl jasmonate and Bacillus subtilis LLCG89 suppresses blue and green mold of lemon (Citrus limon L.).

Background: Bacillus species produce antimicrobial lipopeptides (LPs) and methyl jasmonate (MeJA) induces resistance in harvested fruits against postharvest pathogens. However, there is limited evidence of the combined efficacy of Bacillus LPs and MeJA to suppress postharvest diseases.

Results: This study presents the combined effect of Bacillus LPs and MeJA to suppress P.

Bibliometric analysis of trends in dental management of the children with Autism Spectrum Disorder (ASD).

This study aimed to present a complete overview of the trends, difficulties, and improvements in dental treatment for children diagnosed with autism spectrum disorder through rigorous bibliometric analysis. The dimensional database field was chosen to enable the inclusion and recall of the greatest number of relevant entries. All peer-reviewed international journals published between 2004 and 2023 were included in this study.