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Periocular Pigmented Basal Cell Carcinomas: Clinicopathologic Features and Mutational Profile.
Ophthalmic Plast Reconstr Surg
September 2022
King Khaled Eye Specialty Hospital, Riyadh, Saudi Arabia.
Article Synopsis
- Pigmented basal cell carcinomas (PBCC) are a rare type of skin cancer found around the eyes, primarily affecting females and often appearing as solitary masses on the lower eyelid.
- A study of 31 patients revealed that PBCC has similar clinical and pathological features to other basal cell carcinomas (BCC) found in non-periocular areas, with a low recurrence rate during follow-up.
- Next-generation sequencing of tumors showed mutations in various genes, with common variants in PTCH1, TERT, and SMO, along with novel mutations, suggesting potential targets for molecular therapy.
We describe a diabetic patient with left eye endogenous endophthalmitis due to hypervirulent hypermucoviscous (HKVP) originating from right renal abscesses. A rare source of HVKP causing endogenous endophthalmitis. Despite treatment with intravenous ceftazidime and pars plana vitrectomy, the patient required evisceration of the left eye.
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