Real-world clinical outcome of unresectable locally advanced & de-novo metastatic pancreatic ductal adenocarcinoma: a multicentre retrospective study.

Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited treatment options yielding poor outcomes. This study aimed to evaluate the real-world clinical characteristics, treatment patterns, and outcomes of patients with locally advanced unresectable and de-novo metastatic PDAC in Saudi Arabia, providing regional data to compare with international benchmarks.

Methods: This is a retrospective, multicentre study involving 350 patients diagnosed with unresectable locally advanced or de-novo metastatic PDAC between January 2015 and November 2023.

CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans.

Four genes-DAND5, PKD1L1, MMP21, and CIROP-form a genetic module that has specifically evolved in vertebrate species that harbor motile cilia in their left-right organizer (LRO). We find here that CIROZ (previously known as C1orf127) is also specifically expressed in the LRO of mice, frogs, and fish, where it encodes a protein with a signal peptide followed by 3 zona pellucida N domains, consistent with extracellular localization. We report 16 individuals from 10 families with bi-allelic CIROZ inactivation variants, which cause heterotaxy with congenital heart defects.

Utilization of dupilumab in an immunocompromised patient with extensive allergic fungal rhinosinusitis unsuitable for surgical intervention: A case report.

Introduction: Allergic fungal rhinosinusitis (AFRS) is a distinct subset of chronic rhinosinusitis characterized by a type I hypersensitivity to fungi. Immunocompromised patients are at increased risk for fungal infections. This case highlights the complexities of managing AFRS in patients not eligible for surgery.

Treatment satisfaction among patients with psoriasis in Saudi Arabia.

Psoriasis, affecting 2% of the population, burdens individuals physically and emotionally, with adherence challenges (39-73%). Treatment ranges from topical to systemic therapy, including bio-logics. Although biologic therapy improves clinical outcomes, side effects lead 50% of severe cases to prefer topical treatment.

Hypoalbuminemia as a predictor of severe dengue: a systematic review and meta-analysis.

Introduction: Dengue fever is a significant health concern globally, especially in tropical regions. Identifying reliable markers for severe dengue, such as hypoalbuminemia, is crucial for early diagnosis and treatment.

Methods: This review systematically explores the association between hypoalbuminemia and severe dengue.

Bentall Procedure in a Marfan Syndrome Patient With Reduced Ejection Fraction: A Case Report.

Marfan syndrome (MFS) is an autosomal dominant disorder affecting the connective tissue, often leading to aortic root dilation, aneurysm, and dissection. We report on a 35-year-old Bangladeshi female patient with MFS who presented with chest pain, shortness of breath, and a significant aortic root aneurysm, along with a reduced ejection fraction (EF) of 20%-25%. Imaging confirmed significant aortic dilation, and due to the high risk of mortality, an urgent Bentall procedure was performed.

Paratesticular Adenomatoid Tumor Mimicking Testicular Malignancy: A Case Report and Literature Review.

Paratesticular adenomatoid tumors are benign and rare neoplasms, and the management of these lesions is challenging as many cases end up in the operation room due to the lack of specific clinical and radiological features to differentiate them from malignant lesions. We report a case of adenomatoid tumor of the tunica albuginea in a 48-year-old male along with a review of the literature for similar cases in the last 10 years.

Success of Three Materials and Influence of Behavior Guidance in Primary Molar Pulpotomies : A Retrospective Study.

To assess the effectiveness of Biodentine (BD), mineral trioxide aggregate (MTA) and ferric sulfate (FS) as pulpotomy agents in primary molars and evaluate the impact of behavior guidance strategies on pulpotomy success. In this retrospective cross-sectional study, data from 374 cases (50.5 percent male, aged two to 10 years) undergoing 469 pulpotomies at a university pediatric clinic between April 1, 2016 and January 1, 2020 were analyzed.

C-reactive protein (CRP) levels in people with eating disorders: A systematic review and meta-analysis.

Studies suggest that there is a relationship between inflammatory diseases, inflammatory markers such as C-reactive protein (CRP) and psychiatric disorders. In eating disorders, cross-sectional studies have recently examined peripheral CRP levels in blood serum and plasma, which allow a comprehensive meta-analysis. This systematic review and meta-analysis examined studies from three databases, measuring CRP levels in people with eating disorders, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.

Effect of extracellular vesicles derived from oviductal and uterine fluid on the development of porcine preimplantation embryos.

To improve the efficiency of in-vitro-produced (IVP) porcine embryos, we focused on the events that usually occur during in-vivo embryonic transit from the oviduct to the uterus. Extracellular vesicles (EVs) are released by different mammalian cells and are imperative for intercellular communication and reflect the cell's physiological state. Based on these characteristics, EVs were isolated from oviductal and uterine fluid to imitate the in vivo environment and improve the efficiency of IVP embryos.

Effects of Radiotherapy Alone Versus Concomitant Radiotherapy With Temozolomide Chemotherapy on the Outcome of IDH-wildtype Glioblastoma Patients.

Background: Isocitrate dehydrogenase [IDH]-wildtype glioblastoma is an aggressive brain cancer associated with high recurrence and poor overall survival.

Aim: Our study aims to explore the prognostic effects of radiotherapy [RT] alone versus concomitant RT with temozolomide [TMZ].

Methods: A multicentre retrospective study included a cohort of 244 patients diagnosed with IDH-wildtype glioblastoma, and it was analysed from 2013 to 2020.

Assessing the Causes of Acceptance or Refusal of Breast Cosmetic Procedures Among Saudi Women When They Get to Age of Menopause: A Cross Sectional Study-Saudi Arabia.

Introduction: Cosmetic breast surgery encompasses a variety of procedures aimed at enhancing breast appearance and is increasingly popular globally. Despite this trend, the acceptance of such surgeries among Saudi women approaching menopause remains understudied. This research aims to explore the attitudes and perceptions toward cosmetic breast surgery in this demographic, considering cultural and religious influences in Saudi Arabia.

Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta-Analysis.

Background: Duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used to treat various health conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, and off-label for chemotherapy-induced pain. We conducted this systematic review and meta-analysis aiming to test the current evidence regarding effectiveness and safety of duloxetine for postspine surgeries pain.

Methods: We searched the Cochrane Central Register of Controlled Trials, PubMed, Scopus and Web of science databases for relevant articles up to March 2024.

Ensemble learning driven Kolmogorov-Arnold Networks-based Lung Cancer classification.

Early Lung Cancer (LC) detection is essential for reducing the global mortality rate. The limitations of traditional diagnostic techniques cause challenges in identifying LC using medical imaging data. In this study, we aim to develop a robust LC detection model.

Examining nursing students' awareness of various medical errors during clinical internships to enhance patient safety: A multi-center cross-sectional study.

Background: Patient safety is a global concern within health facilities, primarily attributed to medical errors, constituting a significant global public health issue. Patients experiencing medication errors face serious problems, with increasing mortality rates and escalating hospital costs.

Aim: The study aims to examine nursing students' awareness of various medical errors during their clinical internships at Al- Ahsa, identifying types of errors to enhance patient safety.

Exploring optimal control strategies in a nonlinear fractional bi-susceptible model for Covid-19 dynamics using Atangana-Baleanu derivative.

In this article, a nonlinear fractional bi-susceptible [Formula: see text] model is developed to mathematically study the deadly Coronavirus disease (Covid-19), employing the Atangana-Baleanu derivative in Caputo sense (ABC). A more profound comprehension of the system's intricate dynamics using fractional-order derivative is explored as the primary focus of constructing this model. The fundamental properties such as positivity and boundedness, of an epidemic model have been proven, ensuring that the model accurately reflects the realistic behavior of disease spread within a population.

Recurrent Low-grade endometrial stromal sarcoma metastasized to the common iliac veins, extending into the inferior vena cava and right atrium after 12 years: A case report.

Introduction: Extrauterine recurrent metastasis of Low-grade endometrial stromal sarcoma (LG-ESS) to major blood vessels is largely rare with few reported cases.

Case: Herein, we present a case of a 51-year-old female with recurrent LG-ESS that has metastasized after 12 years to the inferior vena cava (IVC) and extended into the right atrium and common iliac veins. Computed tomography showed an intracardiac larger thrombus within the right atrium extending into the inferior vena cava and common iliac veins.

Short term outcomes of the first pediatric cardiac surgery program in Rwanda.

Background: While the number of cardiac surgery programs in sub-Saharan Africa are increasing, it is still insufficient. With only 0.08 pediatric cardiac surgeons per million people, few cardiac centers routinely perform pediatric cardiac surgery.

Managing Early Childhood Caries: A Comparative Review of Preventive and Restorative Approaches.

Early childhood caries (ECC), one of the most common health problems among children aged six years and below, is considered present when one or more surfaces of a tooth are decayed, missing, or filled. Not only does ECC cause pain for a long time, but it also has short- and long-term health consequences in children. In order to treat ECC, holistic management that includes preventive, restorative, and prosthetic intervention is necessary.

Integrating Family Involvement in Neuro-Intensive Care: A Pathway to Enhanced Family Satisfaction in Traumatic Brain Injury (TBI) Management.

Introduction Traumatic brain injury (TBI) is a major health concern due to its poor clinical and functional outcome and its impact on family homeostasis. Often, the stressed and anxious family is not involved in the care process until the rehabilitation phase. This study aimed to evaluate the integration of family involvement in the neuro-intensive care of TBI patients on family satisfaction.

Improving Quality of Care for Vacation-Related Emergency Department Visits: A Narrative Review of Patient Satisfaction and Contributing Factors.

Emergency departments (EDs) encounter substantial challenges during peak vacation periods, including increased patient volumes, limited access to medical histories, language and cultural barriers, insurance complexities, and disruptions in continuity of care. These factors strain emergency department operations, resulting in prolonged wait times, diagnostic errors, and compromised care quality. This study reviews the literature to identify patient satisfaction indicators and common challenges and evaluate strategies to improve patient outcomes during vacation-related emergency department visits.

Multiple Fibrolipomas of the Tongue: A Rare Case Report of a Pediatric Patient With Whole Exome Sequencing of the C2CD3 Gene.

Multiple fibrolipomas of the tongue are rare benign tumors with a prevalence of 0.2% among both adults and children. Moreover, this lesion affecting an infant has not been reported in the literature.

Pulmonary hypertension post-liver transplant: A case report.

Background: Liver transplantation (LTx) is vital in patients with end-stage liver disease, with metabolic dysfunction-associated steatotic liver disease being the most common indication. Primary sclerosing cholangitis (PSC) is an important indication. Portopulmonary hypertension, associated with portal hypertension, poses a significant perioperative risk, making pretransplant screening essential.