The Cancer Driver Genes IDH1 and IDH2 and CD204 in WHO-Grade 4 Astrocytoma: Crosstalk Between Cancer Metabolism and Tumour Associated Macrophage Recruitment in Tumour Microenvironment.

Purpose: IDH1 and IDH2 are hotspot mutations commonly identified in WHO-grade 4 astrocytomas. Their association with TAMs has never been investigated. We aim to explore the crosstalk between the IDH1/2 mutation metabolic effect and TAMs in tumour microenvironment and how this relationship affects the tumour recurrence.

Association of blood group with COVID-19 disease susceptibility and severity in Saudi Arabia.

Background: Novel SARS-CoV-2 (COVID-19) virus has rapidly spread worldwide and was declared a pandemic, making identifying and prioritizing individuals most at risk a critical challenge. The literature describes an association between blood groups and the susceptibility to various viral infections and their severity. Knowing if a specific blood group has more susceptibility to COVID-19 may help improve understanding the pathogenesis and severity of the disease.

Behaviors and Knowledge Related to Intentional Outdoor Tanning Among Adults in the Western Region of Saudi Arabia.

Background: Intentional outdoor tanning is the process through which people expose their skin to ultraviolet (UV) radiation to darken their skin color toward brown or bronze. UV radiation is a well-known modifiable risk factor for photoaging, photoallergic reactions, and phototoxicity.

Objective: The aim of this study was to assess the behaviors and knowledge of intentional outdoor tanning among adults in the western region of Saudi Arabia.

Worst pattern of invasion and other histopathological features in oral cancer as determinants of prognosis and survival rate: A retrospective cohort analysis.

Oral cavity squamous cell carcinoma (OCSCC) is a well-recognized malignancy of the head and neck. Studies on patients with early-stage oral cancer have shown that they develop locally recurring and/or regional lymph node metastasis, which results in disease-associated mortality. Thus, early-stage oral cancer does not always present good prognoses.

Physicians' Knowledge, Practices, and Perceptions of Reporting Communicable Diseases at Primary Health Care Centers in Jeddah, Saudi Arabia: A Cross-Sectional Study.

Background Jeddah has the highest international traffic and is among the most diverse cities in Saudi Arabia. The chance of importing an emerging communicable disease is significant, particularly during the religious seasons. Therefore, timely and accurate reporting of communicable diseases at primary health care centers (PHCCs) is crucial.

The Impact of Snapchat Use on Self-Image and Inclination Toward Cosmetic Procedures in Saudi Arabia.

Background Exposure to social media gives individuals more significant body image concerns, and many studies have emphasized that people with a negative body image are more interested in cosmetic surgery. So, increased exposure to celebrities with aesthetic images and exposure to cosmetic Surgery information and advertisements lead to negative body image in the exposed populations. Aim This study aimed to determine the impact of social media on self-image inclination toward cosmetic procedures.

Unusual Case of Fatal Suffocation Due to Balloon Aspiration in a 23-Month-Old Infant.

Foreign body aspiration is a serious medical emergency and the fifth leading cause of accidental injury-related fatalities. This case involves a 23-month-old infant who aspirated two latex balloons and developed cardiac arrest during balloon extraction. He was revived, but a CT scan revealed hypoxic encephalopathy.

Factors Affecting Patient Satisfaction in Dermatology Clinics in Saudi Arabia.

Background A methodical approach to health services called "quality of care" places an emphasis on both interpersonal and technical competence in the delivery of medical care. One of the key elements of high-quality care is the client's or patient's satisfaction, which includes treating them with respect, being aware of their needs, and meeting those needs. Dermatologists are forced to expand service availability and respond to patients' needs and desires as required through satisfaction surveys as a result of an increase in the number of insured patients and demand for services.

Ipsilateral Concomitant Intertrochanteric and Femoral Shaft Fractures Associated With Metatarsal Bone Fractures: An Unusual Presentation.

Concomitant ipsilateral intertrochanteric and femoral shaft fractures with metatarsal bone fractures in young adults are extremely rare, and there are only a few reports regarding these fractures in the literature. High-energy trauma is a well-known attributable factor for this type of fracture. In this report, we presented a rare case of ipsilateral intertrochanteric and femoral shaft fractures with metatarsal bone (MTB) fractures in a 42-year-old male patient who was a victim of a road traffic accident (RTA).

Pulsed Radiofrequency Ablation for Orchialgia-A Literature Review.

Pulsed radiofrequency, short bursts of radiofrequency energy, has been used by pain practitioners as a non- or minimally neurodestructive technique, an alternative to radiofrequency heat lesions. The clinical advantages and mechanisms of this treatment remain unclear. To review the current clinical implication of the pulsed radiofrequency technique for male patients with chronic scrotal pain.

Preclinical study of vitamin D deficiency in the pathogenesis of metabolic syndrome in rats.

Objective: To explore the impact of vitamin D deficiency (VD-) in the pathogenesis of metabolic syndrome (MetS).

Materials And Methods: Models of (VD-) and (MetS) were induced in male Wister rats by dividing into four groups, group-I for the development of (VD-) by intraperitoneal injection of paricalcitol for 3 weeks, group II for (MetS) model by adding 10% fructose to their drinking water for 8 weeks, the group III for induction of combined (VD- + MetS) and group-IV as a control. Ultimately, the parameters of (VD-) and (MetS) were assessed at zero time and after 8 weeks.

Quality of Life Assessment for Men With Gynecomastia in Saudi Arabia.

Background: Gynecomastia, defined as a benign proliferation of the breasts in males, is a common pathology of breasts among adolescent males. The root cause behind the condition is the hormonal imbalance between androgens and estrogens at the time of puberty. Different treatment options can be used; however, surgery is the preferred option.

Lymph Node Involvement and the Clinical Stage as Predictors of the Survival of Patients With Adenoid Cystic Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis.

In the treatment of various patients, the presence of lymphovascular invasion is a prognostic determinant, often taken into account by surgeons and oncologists. The exact frequency and prognostic impacts of this microscopic event in adenoid cystic carcinoma (ACC) patients are, however, not clear. This systematic review and meta-analysis aimed to investigate the lymph node involvement and the clinical stage of cancer as predictors of ACC prognosis.

A robotic-assisted hybrid coronary revascularization program: Establishment and early experience in the Middle East.

Background: Hybrid coronary revascularization (HCR) is a technique that merges coronary artery bypass grafting surgery and percutaneous coronary intervention (PCI) approaches for the treatment of multivessel coronary artery disease. The surgical component of the procedure is minimally invasive and can be done using robotic technology that avoids the need for sternotomy. Our objective is to study all patients who underwent robotic-assisted HCR (RHCR) to evaluate the feasibility and safety of the procedure during the establishment phase.

Shock Index and Characteristics of "Bounce-Back" Patients in the Emergency Department of King Abdullah Medical City (KAMC): A Retrospective Analysis.

Background "Bounce back" patients is a term used to refer to patients returning to the emergency department within 72 hours after the first visit. This can be attributed to various factors related to diagnosis, management, or the health care system. Objective This study sought to evaluate the extent of bounce-back patients in the emergency department of King Abdullah Medical City (KAMC), Makkah, Saudi Arabia, and then explore the possible relationship between shock index (SI) and bounce-back patients.

Outcomes of root canal treatment of first permanent molars among children in Jeddah, Saudi Arabia: A retrospective cohort study.

Objectives: The first permanent molar (FPM) is considered the tooth most susceptible to caries, as it is the first permanent tooth to erupt in the oral cavity, making it susceptible to environmental conditions that may appear as caries, hypoplasia, or hypomineralization Several treatment options are available for managing deep caries, including root canal treatment (RCT). However, there is a lack of data on the success and failure rates of RCT in FPM among children. This study aimed to determine the success and failure rates of RCT in FPM among children and related factors.

Overprescription of short-acting β -agonists among patients with asthma in Saudi Arabia: Results from the SABINA III cohort study.

Despite near-universal health care and timely updates to treatment guidelines in Saudi Arabia, asthma control remains suboptimal, warranting deeper exploration of its management practices. This study describes asthma characteristics and prescription patterns of short-acting β -agonists (SABAs) in the Saudi Arabia cohort of the SABA use IN Asthma (SABINA) III study. Patients with asthma (aged ≥12 years) from seven sites across Saudi Arabia participated in this cross-sectional study.

Is the volume of the maxillary sinus altered after LeFort I orthognathic surgery? A systematic review and meta-analysis.

Purpose: This systematic review and meta-analysis aimed to investigate anatomical changes in the maxillary sinus after LeFort I osteotomy.

Methods: The study protocol was developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols, and it was registered with the International Prospective Register of Systematic Reviews under registration number CRD42021236412.

Results: Our search strategy yielded 64 articles.

Pediatric Floating Elbow Caused by a Novel Mechanism: A Case Report.

A pediatric floating elbow is a rare condition in which there is a humeral supracondylar fracture with an ipsilateral fracture of one or both bones of the forearm. We report a case caused by an unusual mechanism of a semi-automatic washing machine. This injury, on its own, involves the risk of compartment syndrome, however, this particular child came late.

The dilemma of juvenile fibrous dysplasia versus chronic osteomyelitis of the posterior mandible: A case report.

The clinical and radiographic dilemma of fibrous dysplasia versus osteomyelitis is highlighted in this case of a 4-year-old girl with a bony hard swelling in mandibular body and ramus. Rather than relying on histopathological appearance alone, dental professionals should be familiar with the radiographic differences between the two conditions.

Successful Conservative Management of Traumatic Pancreatic Duct Injury: A Case Report.

Patients with blunt abdominal trauma are at high risk of getting pancreatic injury, with high morbidity and mortality rates. The decision to manage the patient operatively depends highly on the condition of the main pancreatic duct (MPD). Conservative management of traumatic MPD injuries is rarely reported in the literature.

The impact of COVID-19 pandemic on hand hygiene adherence among pediatric physicians, in Saudi Arabia.

Introduction: The hand hygiene practice (HHP) is the most effective and simplest preventive measure reduce the risk of infection. HHP is more relevant among pediatric physicians in the context of the COVID-19 pandemic since, children are more vulnerable to infection. Therefore, assessment of the COVID-19 impact on HHP could be useful in minimizing lethal virus transmission from pediatric physicians to patients and vice versa.

Clinical and Radiographic Success of 2% Chlorhexidine Gluconate with Mineral Trioxide Aggregate in Indirect Pulp Treatment of Primary Molars.

To compare the clinical and radiographic success rates of indirect pulp treatment (IPT) in primary molars using mineral trioxide aggregate (MTA) with and without two percent chlorhexidine gluconate (CHX).
A blinded, randomized, controlled clinical trial was performed in a split-mouth desi gn. Eighty primary molars in 40 subjects from four to eight years of age were randomly allocated so that each subject had one tooth treated with MTA and CHX and the other tooth treated with MTA alone.