114 results match your criteria: "King Edward Medical University Lahore.[Affiliation]"
Thiosemicarbazones of isatin have been found to exhibit versatile bioactivities. In this study, two distinct types of isatin-triazole hybrids 3a and 3b were accessed copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC), together with their mono and bis-thiosemicarbazone derivatives 4a-h and 5a-h. In addition to the characterization by physical, spectral and analytical data, a DFT study was carried out to obtain the optimized geometries of all thiosemicarbazones.
View Article and Find Full Text PDFNanomedicine (Lond)
June 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, 63100, Pakistan.
Desvenlafaxine (DES) in conventional dosage forms shows initial burst release after oral administration, leading to exaggeration of its side effects. These side effects can be overcome by a sustained-release dosage form using the chemically inert, low-melting-point lipid Compritol 888 ATO, as it reduces initial burst release. The potential of DES-loaded solid lipid nanoparticles (DES-SLNs) synthesized by ultrasonication-assisted hot-melt encapsulation to modify the release of DES was investigated.
View Article and Find Full Text PDFInt J Surg Case Rep
April 2024
King Edward Medical University Lahore, Pakistan.
is an herbal therapy for various afflictions. It has some potential to be a promising option as an efficacious treatment for COVID-19 patients that can contribute to global healthcare as a relatively cheap therapy but evidence of its use from randomized controlled trials (RCTs) is limited. Therefore, to explore the effect of in combating COVID-19, we undertook this meta-analysis.
View Article and Find Full Text PDFEstimated age-adjusted comparative diabetes prevalence in adults (20-79 years) in Pakistan from the year 2011 to 2021.
View Article and Find Full Text PDFHealth Sci Rep
February 2024
Oli Health Magazine Organization, Research and Education Kigali Rwanda.
Introduction: Epilepsy is characterized by having two or more unprovoked seizures. Understanding the pathogenesis of epilepsy, requires deep investigation into the molecular mechanisms. This helps develop diagnostic techniques, treatments, and pharmacotherapy.
View Article and Find Full Text PDFAsian J Surg
May 2024
Services Institute of Medical Sciences Lahore, Pakistan. Electronic address:
Background: Reconstruction of breast following mastectomy is important in terms of rehabilitating patients of breast cancer. Numerous approaches have been used in the reconstruction process. A procedure that has gained interest of the patients is reconstruction of breast using the autologous form.
View Article and Find Full Text PDFBackground And Aims: The World Health Organization has recently declared the frequent outbreaks of diphtheria in Nigeria as a public health concern. Although vaccination efforts have been successful in Nigeria, unfortunately, the recent 2023 outbreak in Nigeria has been nothing short of distressing. Of course, cases of diphtheria incidence are under-reported in Nigeria.
View Article and Find Full Text PDFIntroduction: Mass malaria vaccination, rather than vaccinating only children below age 5, has been proven to have the potential to reduce morbidity and mortality among those vaccinated, both young and old. Addressing vaccine scepticism and misinformation is crucial in African nations to build public trust in malaria prevention. Therefore, including a wider range of demographics in vaccine trials is necessary for equitable representation and achieving herd immunity against malaria.
View Article and Find Full Text PDFHealth Sci Rep
December 2023
Oli Health Magazine Organization, Research and Education Kigali Rwanda.
Hydrocephalus occurs when the cerebrospinal fluid (CSF) accumulates in the cerebral ventricles. This is due to either obstruction in the CSF flow, decreasing its absorption by the arachnoid villus to the Dural venous sinuses, or increasing production of the CSF. The most disproportionately and severely affected by the disease consequences are African children.
View Article and Find Full Text PDFHealth Sci Rep
December 2023
Department of Medicine Oli Health Magazine Organization, Research, and Education Kigali Rwanda.
Ann Med Surg (Lond)
December 2023
Department of Surgery, Assab Military Hospital, Assab, Eritrea.
Geographic atrophy (GA) is a progressive form of age-related macular degeneration characterized by the degeneration of retinal pigment epithelial cells and photoreceptor death. The dysregulation of the complement cascade has been implicated in GA progression. This review provides a comprehensive overview of the pathophysiology of age-related macular degeneration and GA, discusses current therapeutic options, and focuses on the recent breakthrough drug, pegcetacoplan (SYFOVRE).
View Article and Find Full Text PDFBackground: Malaria is a parasitic infection primarily caused by four main species of the genus , that is, , , , and . It is transmitted through the bite of the female mosquito. It holds the status of one of the leading causes of death in the developing world.
View Article and Find Full Text PDFSaudi Pharm J
October 2023
Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
The growing concerns and cases of COVID-19 with the appearance of novel variants i.e., BA.
View Article and Find Full Text PDFHealth Sci Rep
September 2023
Oli Health Magazine Organization, Research and Education Kigali Rwanda.
Key Clinical Message: In non-healing ulcers with a previous history of burns, clinicians should have a high index of suspicion for Marjolin's ulcer and a low threshold for biopsy, irrespective of age.
Abstract: Marjolin's ulcer is a rare malignancy arising from chronic inflammation and commonly manifests in burn scars. Thus, in cases of chronic wounds or non-healing ulcers, health professionals should have a high index of suspicion and a low threshold for biopsy, irrespective of age.
Health Sci Rep
August 2023
Oli Health Magazine Organization, Research and Education Kigali Rwanda.
Pathol Res Pract
August 2023
Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Electronic address:
The role of 27-hydroxycholesterol (27-OHC) in autoimmune diseases has become a subject of intense research in recent years. This oxysterol, derived from cholesterol, has been identified as a significant player in modulating immune responses and inflammation. Its involvement in autoimmune pathogenesis has drawn attention to its potential as a therapeutic target for managing autoimmune disorders effectively.
View Article and Find Full Text PDFBackground: Human immunodeficiency virus (HIV) is a retrovirus that suppresses the immune system by reducing the CD4+ T lymphocytes level. It has become a global challenge with fast prevalence ratio. Like other developing countries, Pakistan is also struggling for overcoming this viral disease since very first reported case in 1987.
View Article and Find Full Text PDFKey Clinical Message: Guillain-Barré syndrome (GBS) is a rare but possible complication that may occur after COVID-19 vaccination. In this systematic review, we found that GBS presented in patients with an average age of 58. The average time for symptoms to appear was 14.
View Article and Find Full Text PDF