Effectiveness and Safety of GLP-1 Receptor Agonists in Patients with Type 1 Diabetes.

: GLP-1 receptor agonists (GLP-1RA) are used in the management of type II diabetes mellitus or obesity, although its role in patients with type I diabetes mellitus (T1DM) has been debated. This study aimed to investigate the efficacy and safety of GLP-1RA in patients with T1DM using real-world data. : This multicenter, retrospective study was conducted at three tertiary medical centers in Riyadh, Saudi Arabia.

Exploring the Challenges and Solutions in Conducting Clinical Trials in Saudi Arabia: A Qualitative Study Perspective.

Introduction: Clinical trials are crucial for advancing medical knowledge and improving healthcare outcomes. Despite an increase in research publications in Saudi Arabia, clinical trial productivity has lagged behind. Understanding the barriers to conducting clinical trials in Saudi Arabia is essential.

Knowledge and awareness toward human papillomavirus vaccination among Saudi female nursing students.

Introduction: Human Papillomavirus is a sexually transmitted agent, causing cervical cancer. In Saudi Arabia, cervical cancer is ranked as the ninth most common carcinoma in women. HPV vaccine is an effective prevention method against HPV high-risk types such as HPV 18 and 16.

National survey on Congenital Cytomegalovirus Awareness and Screening Practices among Healthcare Professionals.

Objectives: Congenital cytomegalovirus (CMV) infection, resulting from maternal-fetal transmission of CMV, poses a substantial risk to maternal and child health. It is the most prevalent congenital viral infection, and the prevention and management of this condition rely heavily on the knowledge and awareness of healthcare professionals.

Methods: This cross-sectional survey was conducted between March 1, 2023, and August 31, 2023, across multiple tertiary centers in various Saudi Arabian cities.

Utilization of digitally milled verification jigs for recording jaw relations in complete-arch implant rehabilitation: A digital clinical report.

This clinical report introduces a digital approach that utilizes milled verification jigs to acquire the jaw relations for the fabrication of monolithic zirconia implant-supported fixed complete dental prosthesis (IFCDP), in patients without a conversion implant prosthesis. The procedures employ photogrammetry for precise data acquisition, combined with image-based capture in 4 dimensions (ICAM4D), to design and mill verification jigs that accurately record the occlusal vertical dimension (OVD) and centric relation (CR). This approach streamlines the clinical workflow by reducing the number of patient visits and associated costs while enhancing precision and predictability.

Anticancer Effects of New Disulfiram Analogs.

Disulfiram (DSF), an irreversible aldehyde dehydrogenase 2 (ALDH2) inhibitor, is an U.S. Food and Drug Administration (FDA)-approved drug for the treatment of chronic alcoholism.

Artificial intelligence for orthodontic diagnosis and treatment planning: A scoping review.

Objectives: To provide an overview of artificial intelligence (AI) applications in orthodontic diagnosis and treatment planning, and to evaluate whether AI improves accuracy, reliability, and time efficiency compared to expert-based manual approaches, while highlighting its current limitations.

Data: This review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist.

Sources: An electronic search was performed on PubMed, Web of Science, and Embase electronic databases.

Exploring the effectiveness of the Career Guidance and Counseling Program on the perceived readiness for the job market: a lived experience among nursing students.

Background: The current workforce demands that nursing graduates possess the necessary skills and knowledge to perform in complex clinical and professional environments. Career guidance can potentially improve students' job readiness by increasing their confidence in career pursuits, simplifying career decisions, and helping them address decision-making challenges.

Methods: This phenomenological study aimed to explore nursing students and interns' perspectives on the effectiveness of the Career Guidance and Counseling Program (CGCP) and its impact on their readiness for the job market through their lived experiences while participating in the program.

Perspectives from program directors on the selection process for Saudi periodontics residency programs: a cross-sectional study.

Background: Applying to periodontics programs in Saudi Arabia holds significant importance for both applicants and periodontics program directors. As of today, there has been no investigation into how periodontics program directors (PDs) identify and select potential candidates for their programs. The aim of this study is to assess the factors taken into consideration during the selection process for periodontics programs by PDs in Saudi Arabia.

Clinical Characteristics and Outcome of Brucella Endocarditis: A Case Series.

Purpose:  Brucella endocarditis is a rare complication with a high mortality risk. This research aims to evaluate patients diagnosed with Brucella Endocarditis and review clinical characteristics, diagnosis, and treatment strategies to serve as a foundation for future research in managing Brucella endocarditis and improving patient care and outcomes.

Patients And Methods: This retrospective study reviewed the medical records of patients diagnosed with Brucella endocarditis from 2011 to 2022.

Saudi Radiology Technologists' Perception of Occupational Hazards from a Personal and Social Lens.

Background: Occupational hazards among healthcare workers (HCWs) present serious risks, from infectious diseases to physical and chemical dangers, along with psychological stress, all of which threaten their health and safety. This study aims to identify the unique challenges and hazards encountered by radiology technologists in in Saudi Arabia by assessing the key factors contributing to these risks.

Methods: A descriptive questionnaire study was conducted in January-February 2023, targeting 75 radiology technologists at King Abdulaziz Medical City (KAMC), Jeddah, with participants recruited via non-probability convenience sampling and invited to complete a widely recognized questionnaire previously used among radiographers.

Poor perceived oral health is associated with adverse mental health outcomes among Syrian refugees in Canada.

While inadequate oral health has been linked to adverse mental health outcomes, there is limited understanding of such implications among refugees who bear a disproportionate burden of oral health disparities. This study aims to examine the effect of self-rated oral health on depression, anxiety, and stress among Syrian refugee parents resettled in Ontario. In this cross-sectional study, a total of 540 Syrian refugee parents who resided in Ontario for an average of 4 years and had at least one child under 18 years old were interviewed between March 2021 and March 2022.

Psychological Scars Shouldn't be Ignored: Addressing Factors Linked to Depression among Individuals with Laparoscopic Sleeve Gastrectomy.

Introduction: Although bariatric surgeries have been linked to improved mental health, yet, some individuals develop depression.

Objectives: The present study aimed to assess the levels of depression and examine factors linked to depression among individuals with laparoscopic sleeve gastrectomy (LSG) in Saudi Arabia.

Methods: A cross-sectional design using a digital online survey was used to collect data.

The incidence and risk factors of post-transplant diabetes mellitus in living donor kidney transplantation patients: a retrospective study.

Background: Post-transplant diabetes mellitus (PTDM) is a well-known complication of kidney transplantation that significantly impacts recipient morbidity and mortality. Over the recent years, the incidence of PTDM has increased considerably worldwide. Therefore, the primary purpose of this study was to evaluate the incidence and risk factors for PTDM in living donor kidney transplantation patients in Riyadh, Saudi Arabia.

Minimally Invasive Surgery for Spontaneous Intracerebral Hemorrhage: Meta-Analysis of High-Quality Randomized Clinical Trials.

Objectives: Spontaneous intracerebral hemorrhage (ICH) poses high mortality and morbidity rates with limited evidence-based therapeutic approaches. We aimed to evaluate the current evidence for the role of minimally invasive surgery (MIS) in the management of ICH.

Methods: This systematic review and meta-analysis followed recommended guidelines and protocols.

Disaster Knowledge, Skills, and Preparedness among Emergency Medical Services in Saudi Arabia.

Objectives: Emergency Medical Services (EMS) workers are critical to effective disaster response. Therefore, it is important to understand their knowledge, skills, and preparedness for disasters. This study investigated factors influencing EMS workers' disaster knowledge, skills, and preparedness in the Saudi Arabian context.

Clinical, Radiological Features and Treatment Outcomes of Tuberculosis in Patients Aged 75 Years and Older.

Introduction: Tuberculosis (TB) is a significant contributor to morbidity and mortality. With a progressively aging population, TB is increasingly encountered in older adults. Understanding the clinical presentation and optimal treatment strategies for TB in this population is essential.

Perceptions Regarding the Use of E-cigarettes Among Smokers in Saudi Arabia.

Background Adults and young people select electronic cigarettes (ECs) due to their perceived lower risk compared to traditional combustible cigarettes. Objective This study aimed to measure the perceptions of the use of electronic cigarettes as a smoking cessation tool among the population of Saudi Arabia. Methods Between October 2023 and November 2023, we conducted a cross-sectional study of Saudi Arabia's general population over prominent social media platforms.

Comparative Analysis and Spatial Distribution of the Primary Health Care Centers and Health Manpower Across Saudi Arabia Using Shapiro-Wilk Test.

Background: Due to the growing demand for better health services by the population pressure, Saudi Arabia is facing challenges in providing the required coverage in primary health care over all regions.

Study Objectives: The study aims to do a comparative analysis of the spatial distribution of the primary healthcare centers and health manpower across Saudi Arabia.

Study Methods: This study deals with the analysis of the spatial distribution of the PHCCs and health manpower in Saudi Arabia regions during the period 2017-2021 by applying the Shapiro-Wilk test.

MERS-CoV Infection and Its Impact on the Expression of TSLP Cytokine and IgG Antibodies: An In Vivo and In Vitro Study.

Purpose: Thymic stromal lymphopoietin (TSLP) is a proinflammatory cytokine produced by epithelial cells that is involved in the activation of allergic disorders. To date, no study has examined TSLP induction during Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Herein, we aimed to study the effects of the recombinant spike protein of MERS-CoV on TSLP production.

Ocular findings in the evaluation of abusive head trauma in children.

Purpose: Abusive head trauma (AHT) is a form of child physical abuse that can result in major ocular injuries. This study describes the clinical presentation and ocular manifestations of infants diagnosed with AHT in a tertiary care center in Saudi Arabia.

Methods: This is an observational, retrospective, cross-sectional study from 2015 to 2022 conducted at King Abdullah Specialized Children's Hospital (KASCH) in Riyadh, Saudi Arabia.