A Saudi Heart Association Position Statement on Cardiovascular Diseases and Diabetes Mellitus.

Background: Cardiovascular disease (CVD) and diabetes mellitus are prominent public health concerns in Saudi Arabia owing to their increasingly high prevalence and burden. Based on this, the Saudi Heart Association (SHA) set out to develop an official position statement on CVD and diabetes mellitus, with a focus on the prevention and management of these conditions and relevant special populations in the context of Saudi Arabia.

Methods: A multidisciplinary panel of experts met under the auspices of the SHA in a series of meetings to review and discuss available evidence on the prevention and management of comorbid CVD and diabetes mellitus.

Study of the Prevalence of Human Papillomavirus Genotypes in Jeddah, Saudi Arabia.

Human papillomavirus (HPV), a common sexually transmitted infection, includes over 200 types, some linked to genital warts and various cancers, including cervical, anal, penile, and oropharyngeal cancers. In Saudi Arabia, an estimated 10.7 million women aged 15 years and older are at risk of HPV-related cervical cancer.

Hand Rejuvenation Using Autologous Fat Grafting: A Systematic Review of Recommended Doses, Complications, and Patient Satisfaction.

Introduction: Hand rejuvenation addresses aging-related changes such as subcutaneous fat loss, skin degradation, and photodamage. Autologous fat transfer (AFT) has emerged as a promising treatment, offering durable volume augmentation and regenerative effects. This study aims to systematically review the evidence on the techniques, outcomes, and complications of AFT for hand rejuvenation.

Case report: Kabuki syndrome and persistent hypoglycemia in neonates.

The Kabuki syndrome (KS) is a rare congenital disease that has two different types, KS1 and KS2, with variant in epigenetic gene KMT2D and KDM6A, respectively. It is associated with multiple abnormalities such as (developmental delay, atypical facial features, cardiac anomalies, minor skeleton anomalies, genitourinary anomalies, and mild to moderate intellectual disability). This syndrome can lead to neonatal hypoglycemia that results from hyperinsulinemia and electrolyte abnormalities.

Hepatobiliary manifestations of inflammatory bowel disease in Saudi Arabia: A retrospective analysis.

Objectives: To evaluate the features and frequency of hepatobiliary diseases in individuals with Inflammatory bowel disease (IBD).

Methods: This retrospective study included all IBD patients at King Abdulaziz University Hospital in Jeddah, Saudi Arabia. The primary focus was on the prevalence of hepatobiliary diseases, such as primary sclerosing cholangitis (PSC), non-alcoholic fatty liver disease (NAFLD), autoimmune hepatitis (AIH), and others.

Prevalence of Ear, Nose, and Throat Problems in Saudi Arabia: A Cross-Sectional Study.

Background Ear, nose, and throat (ENT) disorders are common and significantly impact the quality of life. This study aimed to assess the prevalence of ENT problems among the Saudi population and to explore its association with sociodemographic factors, knowledge, and healthcare utilization. Methodology A cross-sectional study was conducted among 405 participants aged 18-80 years across Saudi Arabia.

Exploring sleep-related disorders in patients with multiple sclerosis: A questionnaire-based approach.

Background: Multiple sclerosis (MS) is considered the most prevalent neurological disorder in young adults with many patients manifesting sleep-related disorders (SRD) due to its pathomechanisms. This is subsequently reflected in patients' quality of life and physical activities.

Material And Methods: This is a cross-sectional study at a tertiary care center.

Efficacy and Safety of Prophylactic Agents in Prevention of Retinopathy of Prematurity: A Systematic Review and Meta-analysis of Randomised Controlled rials.

Objective: Retinopathy of prematurity (ROP) is a leading cause of preventable childhood blindness in preterm infants with low birth weight. The efficacy and safety of prophylactic agents, including vitamin A, propranolol and lipids, in reducing ROP incidence remain unclear. This systematic review and meta-analysis evaluated the effectiveness and safety of these agents in preventing ROP.

Point shear wave elastography application in assessment pancreas tissue stiffness: A pilot study.

Introduction: Recent advancements in medical imaging, such as point shear wave elastography (pSWE), offer non-invasive methods to assess tissue stiffness and structural changes. This study explores the use of pSWE to evaluate pancreatic stiffness and dimensions in three different pancreas parts.

Methods: This study was conducted at diagnostic radiology department, King Abdulaziz University Hospital, Jeddah, between June 2022 and November,2022.

Unusual Presentation of a Pediatric Burkitt's Lymphoma With Infiltration of the Interatrial Septum.

Background: Burkitt's lymphoma (BL) is the most common subtype of non-Hodgkin lymphoma in children, typically presenting with extranodal masses in areas such as the abdomen, face, and neck. Cardiac involvement in BL is extremely rare, especially in pediatric patients, and has significant implications for diagnosis, management, and prognosis.

Case Presentation: A 6-year-old male patient with Burkitt's lymphoma, presenting with an uncommon infiltration of the interatrial septum, is described.

Real-World safety and effectiveness of evolocumab in primary hypercholesterolemia and mixed dyslipidemia in Saudi Arabia.

Introduction: Evolocumab's short-term efficacy and safety were proven in phase-3 clinical trial, but its long-term safety and effectiveness in the Saudi population are yet to be studied. The aim of this study was to assess the long-term safety and effectiveness of evolocumab in Saudi patients with primary hypercholesterolemia or mixed dyslipidemia.

Method: A retrospective cohort study evaluated adult patients who had newly been prescribed evolocumab for hypercholesterolemia or mixed dyslipidemia.

Nationwide survey on awareness of consanguinity and genetic diseases in Saudi Arabia: challenges and potential solutions to reduce the national healthcare burden.

Background: Consanguineous marriage is a major contributing factor for many genetic diseases and a burden to the healthcare system and national economy due to costly long-term care. Earlier studies highlighted the significantly limited awareness of the higher prevalence of genetic disease due to consanguinity even among the educated Arabs. In Saudi Arabia, more than 50% of marriages are between first cousins.

JAK2-V617F mutation among blood donors: A meta-analysis.

Objectives: To systematically review evidence on the prevalence of the JAK2V617F (JAK2) mutation and polycythemia vera (PV) among all blood donors, focusing on those with elevated hematocrit. Although blood donors are generally healthy, considering a preclinical stage of myeloproliferative neoplasm, especially in those with polycythemia, is crucial. Evidence on managing these donors is limited.

Epidemiological and Clinical Insights into : A Six-Year Study on Age, Antibiotics, and Specimens.

Background: This six-year retrospective study provides an in-depth analysis of the epidemiological and clinical patterns associated with () infections, focusing on age distribution, antibiotic resistance profiles, and specimen types.

Aim: The research examines the incidence and characteristics of non-Multi-Drug Resistant (non-MDR) and Multi-Drug Resistant (MDR) strains by reviewing patient records from January 2016 to December 2022.

Methods: Through a statistical analysis, the study highlights the incidence rates across diverse age groups and explores the impact of antibiotic treatment regimens on infection outcomes.

Unraveling the Prognostic Role of t(1:19) in Pediatric Pre-B Acute Lymphoblastic Leukemia: Insights from a Saudi Nationwide Cohort.

Recurrent translocation t(1;19) (q23;p13) describes a unique cytogenetic group of childhood B-cell acute lymphoblastic leukemia (ALL). Historically, t(1;19)(q23;p13.3) has been associated with poor outcomes.

Intraoperative iatrogenic seizure induced by transcranial motor-evoked potential during spinal surgery: A case report and review of the literature.

Background: Intraoperative neuromonitoring is an essential tool for detecting early intraoperative neurological changes during spinal surgery. Only rarely do seizures occur during transcranial motor-evoked potentials (TcMEP).

Case Description: A 44-year-old male presented with a magnetic resonance (MR)--documented L5-S1 T2-hyperintense intradural mass that heterogeneously enhanced with Gadolinium and extended through the right S1 neural foramen.

Exploring somatic mutations in , , and as therapeutic targets in Saudi colorectal cancer patients through massive parallel sequencing and variant classification.

Background: Colorectal cancer (CRC) is the leading cancer among Saudis, and mutations in , , and genes are therapeutically significant due to their association with pathways critical for cell cycle regulation. This study evaluates the prevalence and frequency of somatic mutations in these actionable genes in Saudi CRC patients and assesses their pathogenicity with bioinformatics methods.

Methodology: The study employed the TruSight Tumor 15 next-generation sequencing (NGS) panel on 86 colorectal cancer (CRC) samples to detect somatic mutations in , , and genes.

Bloodstream infections caused by Staphylococcus aureus in patients admitted to King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Objective: Currently, there is a limited amount of published data on the incidence of bloodstream infections (BSI) caused by both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible Staphylococcus aureus (MSSA) in most parts of the Arabian Peninsula. Thus, it is extremely important to have information concerning the distribution and prevalence of MRSA and MSSA to better handle and manage future epidemics.  This study aimed to investigate the correlation between MRSA and/or MSSA with BSI at King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia.

A Systematic Review of the Long-Term Outcomes of Surgical Versus Non-surgical Management for Types A3 and A4 Thoracolumbar Spinal Fractures With No Neurological Deficits.

Thoracolumbar spinal fractures remain a significant concern in the orthopedic and neurosurgical practice and have a risk of neurological deficits in patients. However, in the majority of the cases, the neurological status remains intact. Generally, conservative management is favored for fractures of low severity and the surgical option is reserved for severe fractures.