Urinary Incontinence (UI) in Saudi Female Population: Prevalence, Risk Factors, and Impact on Quality of Life.

Background: Urinary incontinence (UI) is a prevalent health concern among women globally. However, its prevalence, associated risk factors, and impact on quality of life among Saudi women remain underexplored.

Objective: This study aimed to assess the prevalence of UI, identify its risk factors, and understand its impact on the quality of life among Saudi women.

Acute Severe Ulcerative Colitis: An International Delphi Consensus on Clinical Trial Design and Endpoints.

Background & Aims: Interventional clinical trials in acute severe ulcerative colitis (ASUC) are characterized by substantial heterogeneity due to a lack of consensus in several key areas of trial design-this impedes clinical research efforts to identify novel therapies. The objective of this initiative was to achieve the first consensus and provide clear position statements on ASUC trial design.

Methods: A modified Delphi consensus approach was employed with a panel of 20 clinicians with international representation and expertise in ASUC trial design and delivery.

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity.

Autosomal recessive deficiency of the IFNAR1 or IFNAR2 chain of the human type I IFN receptor abolishes cellular responses to IFN-α, -β, and -ω, underlies severe viral diseases, and is globally very rare, except for IFNAR1 and IFNAR2 deficiency in Western Polynesia and the Arctic, respectively. We report 11 human IFNAR1 alleles, the products of which impair but do not abolish responses to IFN-α and -ω without affecting responses to IFN-β. Ten of these alleles are rare in all populations studied, but the remaining allele (P335del) is common in Southern China (minor allele frequency ≈2%).

Influence of Work-Life Balance on Mental Health Among Nurses: The Mediating Role of Psychological Capital and Job Satisfaction.

Background: Nurses constitute the backbone of the healthcare sector, often confronting elevated levels of work-related stress and emotional demands that can profoundly impact their mental well-being. Mental health is critical to nursing practice as it directly influences job performance, patient care quality, and workforce sustainability. This study examines the effects of work-life balance on the mental health of nurses in Pakistan while examining the intermediary effects of psychological capital and job satisfaction.

Impact of Spinal Anesthesia Dosage in Elective Cesarean Section on the Duration of Stay in Post-Anesthesia Care Unit at the Women's Health Hospital, National Guard Health Affairs.

In the field of obstetrics, cesarean sections have now become the most prominent procedure for the delivery of newborns. Cesarean sections may be handled with a variety of different anesthetic approaches, of which most focus seems to be on that of spinal forms, due to their rapid and effective action. Dosages of spinal anesthesia formulations differ depending on multiple variables, such as depth of anesthesia, level of analgesia, and desired duration of effects.

Evaluating the Effectiveness of Basic Life Support (BLS) and Advanced Cardiovascular Life Support (ACLS) Training for Family Medicine Residents in Saudi Arabia.

Background: This study aims to assess the knowledge level of family medicine physicians in Saudi Arabia, regarding basic life support (BLS) and advanced cardiovascular life support (ACLS). Recognizing the importance of timely and effective resuscitation in emergency medical care, the study explores the physicians' proficiency in key resuscitation concepts and identifies areas for improvement.

Methodology: Conducted as an observational cross-sectional study in Saudi Arabia, the research involved family medicine physicians from major hospital centers.

Comparing Thulium Fiber Versus High-Power Holmium Laser Lithotripsy Combined with the Flexible and Navigable Suction Access Sheath in Flexible Ureteroscopy for Kidney Stone Disease: A Propensity Score Matched Analysis by the Global FANS Collaborative Group.

We aim to evaluate stone-free rate (SFR) and complications after flexible ureteroscopy (F-URS) for kidney stones, using a flexible and navigable suction ureteral access sheath (FANS), comparing thulium fiber laser (TFL) and high-power holmium:yttrium-aluminum-garnet laser (HPHL). Data from adults who underwent F-URS in 15 centers were prospectively analyzed (August 2023-January 2024). Exclusion criteria were ureteral stones, concomitant bilateral procedures, and renal abnormalities.

The Impact of Intoxication on the Prognosis of High-Speed Motor Vehicle Accidents: A Tertiary Care Center Experience.

Introduction: Several studies suggest a causal link between psychoactive agents and motor vehicle accidents (MVA). This study aimed to evaluate the impact of substance abuse and alcohol intoxication on the prognosis of high-speed MVA victims.

Methods: This is a single-center retrospective cross-sectional study involving adult multiple trauma cases who were admitted to the emergency department for high-speed MVA and underwent toxicological screening.

A Nationwide Study: Medical Students' Perceptions of Plastic Surgery and Its Role in Career Choice in Saudi Arabia.

Background Plastic surgery is a dynamic field within medicine, shaped by various factors that impact medical students' perceptions and career choices. This study aimed to assess medical students' perceptions of plastic surgery as a specialty career and to examine factors influencing it, particularly understanding the impact of demographics, educational exposure, and media. Methods A cross-sectional study involved 777 medical students from diverse universities across Saudi Arabia.

-related disorder in 87 adults: Natural history and self-sustainability.

Purpose: is one of the most frequently mutated genes in intellectual disability cohorts. Thus, far few adult-aged patients with -related disorder have been described, which limits our understanding of the disease's natural history and our ability to counsel patients and their families.

Methods: Data on patients aged 18+ years with -related disorder were collected through an online questionnaire completed by clinicians and parents.

The role of effective dose in medicine now and into the future.

Effective dose was created as a radiological protection dose quantity linked to risk to enable planning of radiological protection for the control of exposure. Its application and use has evolved from occupational and public exposure during work with radiation sources to medicine and applications in patient dosimetry. Effective dose is the sum of doses to organs and tissues within the body weighted according to their sensitivity to radiation for induction of stochastic effects determined from epidemiological studies of exposed populations.

Oral Rehabilitation of a Child Superimposed with Tooth Impaction and Ranula.

Introduction: Dental impaction may be due to several etiological factors, including genetic conditions, lack of space, failure of primary tooth resorption and prolonged retention of these teeth, presence of intraosseous cysts, and trauma in the region. The ranula is a mucus-filled cyst-like mass that usually originates from extravasation of mucus from the sublingual gland.

Case Description: A 7-year-old Saudi female presented to the pediatric dental clinic at Prince Mohammed Bin Abdulaziz Hospital (PMBAH), Al-Madinah al-Munawwarah, Saudi Arabia, with complicated orodental problems that were identified after clinical and radiological assessment, including the following: an intruded primary central incisor in close relation to the nasal cavity, hypodontia, hypomineralization, multiple carious teeth, abscess, and sublingual ranula.

A bibliometric analysis of inflammatory bowel disease research in the Arab world.

Background: The prevalence of inflammatory bowel disease (IBD) continues to increase worldwide, including in the Arab world. This study investigates IBD research output in Arab countries from 2009 to 2023, alongside prevalence and incidence trends.

Methods: We utilized bibliometric analysis with data from Clarivate Analytics, the Institute for Health Metrics and Evaluation, and the World Bank.

Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial.

Importance: Sepsis screening is recommended among hospitalized patients but is supported by limited evidence of effectiveness.

Objective: To evaluate the effect of electronic sepsis screening, compared with no screening, on mortality among hospitalized ward patients.

Design, Setting, And Participants: In a stepped-wedge, cluster randomized trial at 5 hospitals in Saudi Arabia, 45 wards (clusters) were randomized into 9 sequences, 5 wards each, to have sepsis screening implemented at 2-month periods.

JAK2-V617F mutation among blood donors: A meta-analysis.

Objectives: To systematically review evidence on the prevalence of the JAK2V617F (JAK2) mutation and polycythemia vera (PV) among all blood donors, focusing on those with elevated hematocrit. Although blood donors are generally healthy, considering a preclinical stage of myeloproliferative neoplasm, especially in those with polycythemia, is crucial. Evidence on managing these donors is limited.

Prevalence of hyperlipidemia in psoriatic arthritis patients in Riyadh, Saudi Arabia.

Objectives: To estimate the prevalence of hyperlipidemia in patients with psoriatic arthritis (PsA) in Riyadh, Saudi Arabia, and to investigate the relationship between PsA and hyperlipidemia.

Methods: This retrospective study examined medical records of PsA patients from January 2010 to May 2023 at 2 medical centers in Riyadh. Patients over 18 years old with a lipid profile were included.

Association between oral loop diuretics duration before discharge and hospital readmission in acute decompensated heart failure: A multicenter retrospective cohort study.

There are uncertainties when to start patients on oral loop diuretics after managing acute decompensated heart failure (ADHF) before discharge. This study aims to investigate the impact of prolonging observation duration on hospital readmissions following the switch to oral loop diuretics before discharge in patients with ADHF. A multicenter retrospective study that included adult patients (>18 years) diagnosed with ADHF and discharged on oral loop diuretics in Saudi Arabia.

Advanced trauma life support training outcomes in Saudi Arabia: a four-year multicenter analysis of influential characteristics and factors (2019-2023).

Background: The prevalence of trauma necessitates effective training for healthcare providers in Saudi Arabia. The Advanced Trauma Life Support (ATLS) program is pivotal, yet localized success rate data are lacking.

Objectives: Determine the failure rate and identify factors influencing ATLS course success rates among physicianss in Saudi Arabia.

Knowledge and Attitudes of Saudi Medical Students Toward Forensic Medicine as a Subspecialty: A Cross-Sectional Study.

Background: The field of forensic medicine, also known as medical jurisprudence, plays a vital role in civil and criminal legal proceedings by applying medical principles to establish facts. Despite its critical importance, there is a significant shortage of experts in this subspecialty. Understanding the factors influencing medical students' interest in forensic medicine is crucial.

Assessment of Thyroid Function in Chronic Kidney Disease Patients at King Abdulaziz Medical City.

Background Chronic kidney disease (CKD) is a progressive and irreversible condition in which the kidneys lose their ability to perform synthetic, excretory, and metabolic functions. CKD is associated with various pathophysiological conditions that impact multiple organs, including the thyroid gland, which primarily secretes triiodothyronine (T3) and thyroxine (T4). This study aims to assess thyroid function in patients with CKD and explore the relationship between renal disease severity and thyroid function.

Shifting Trends of Antimicrobial Resistance Patterns Among Uropathogenic Bacteria Before and During the COVID-19 Pandemic.

Urinary tract infections (UTIs) represent a significant global health concern, primarily caused by uropathogenic bacteria and their rising trend of antimicrobial resistance (AMR). This study investigates the prevalence and pattern of AMR among uropathogenic bacteria during the COVID-19 pandemic, highlighting its impact on antimicrobial usage and resistance trends. This retrospective cross-sectional study, conducted at King Fahad Medical City, Riyadh, Saudi Arabia, from January 1, 2018, to December 31, 2022, analyzed 10,031 patients with positive urine cultures for resistance patterns pre-COVID-19 and during COVID-19.

Epidemiological and Clinical Insights into : A Six-Year Study on Age, Antibiotics, and Specimens.

Background: This six-year retrospective study provides an in-depth analysis of the epidemiological and clinical patterns associated with () infections, focusing on age distribution, antibiotic resistance profiles, and specimen types.

Aim: The research examines the incidence and characteristics of non-Multi-Drug Resistant (non-MDR) and Multi-Drug Resistant (MDR) strains by reviewing patient records from January 2016 to December 2022.

Methods: Through a statistical analysis, the study highlights the incidence rates across diverse age groups and explores the impact of antibiotic treatment regimens on infection outcomes.