Paired electrolysis enabled annulation for the quinolyl-modification of bioactive molecules.

A paired electrolysis enabled cascade annulation that enables the efficient synthesis of highly functionalized quinoline-substituted bioactive molecules from readily available starting materials is reported. Using this methodology, two goals, namely, the direct synthesis of quinolines and the introduction of quinoline moieties to bioactive molecules, can be simultaneously achieved in one simple operation. The use of electroreduction for the activation of isatin, together with the further anodic oxidation of KI to catalytically result in a cascade annulation, highlight the unique possibilities associated with electrochemical activation methods.

Prebiotic properties of jiaogulan in the context of gut microbiome.

Jiaogulan () is a traditional Chinese medicinal herb that has been widely used in food and supplemental products. In the last 20 years, extensive research has been conducted to investigate the medicinal prospects of jiaogulan, and in this regard, more than 200 compounds have been isolated with various medicinal properties such as anticancer, anti-obesity, anti-inflammation, and antioxidation. In respect of potential benefits, jiaogulan market is likely growing, and various food items comprised of jiaogulan (beverage, sport drinks, cola, beer, tea, bread, and noodles) have been commercialized in the United States of America, China, and other Asian countries.

Perceived stress and willingness to quit smoking among patients with depressive and anxiety disorders seeking treatment.

Rationale And Objectives: Little are known about nicotine dependence (ND), perceived stress, and willingness to quit smoking at different treatment stages in patient with affective disorders (AD). This study aimed to evaluate the association between ND and perceived stress among patients with AD presenting with psychiatric treatment at different clinical stages (first visit or follow-up), and in different nicotine type users (cigarette and waterpipe smokers). We also aimed to evaluate the willingness to quit smoking and its association with barriers to quitting.

Role of platelet rich plasma mediated repair and regeneration of cell in early stage of cardiac injury.

Platelet-rich plasma (PRP) is a widely accepted treatment approach and has heightened the quality of care among physicians. PRP has been used over the last decade to boost clinical results of plastic therapies, periodontal surgery and intra-bony defects. According to certain research, elevated levels of PRP growth factors that could promote tissue repair and have the potential for PRP to be beneficial in regenerating processes that Maxillofacial and Oral Surgeons, Veterinary Officers, Athletic medicine specialists and Dermatologists have long admired.

Management of a radiopaque foreign body associated with a lower first premolar: A case report.

Operator mishaps significantly affects root canal treatment outcome. However, several factors affect root canal anatomy of teeth. Therefore, knowledge of teeth anatomy and the use of advanced technologies like cone-beam computed tomography (CBCT), magnification, and illumination are crucial for better diagnostic purposes and to avoid any procedural errors.

Generating new mixtures of food additives with antimicrobial and cytotoxic potency against and .

Food additives have been shown to help regulate or prevent the spread of microbes during food manufacturing. Phloxine B, nisin, and sorbic acid were tested to see whether they had a synergistic impact on the inactivation of and , respectively. The combination of phloxine B and nisin had a synergistic interaction (FICI: 0.

SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load.

Monitoring SARS-CoV-2 spread and evolution through genome sequencing is essential in handling the COVID-19 pandemic. Here, we sequenced 892 SARS-CoV-2 genomes collected from patients in Saudi Arabia from March to August 2020. We show that two consecutive mutations (R203K/G204R) in the nucleocapsid (N) protein are associated with higher viral loads in COVID-19 patients.

Nanotechnology-based approaches in the fight against SARS-CoV-2.

The COVID-19 pandemic caused by highly-infectious virus namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in infection of millions of individuals and deaths across the world. The need of an hour is to find the innovative solution for diagnosis, prevention, and cure of the COVID-19 disease. Nanotechnology is emerging as one of the important tool for the same.

A fractional-order model of coronavirus disease 2019 (COVID-19) with governmental action and individual reaction.

The deadly coronavirus disease 2019 (COVID-19) has recently affected each corner of the world. Many governments of different countries have imposed strict measures in order to reduce the severity of the infection. In this present paper, we will study a mathematical model describing COVID-19 dynamics taking into account the government action and the individuals reaction.

Electrochemically selective double C(sp)-X (X = S/Se, N) bond formation of isocyanides.

The construction of C(sp)-X (X = B, N, O, Si, P, S, Se, .) bonds has drawn growing attention since heteroatomic compounds play a prominent role from biological to pharmaceutical sciences. The current study demonstrates the C(sp)-S/Se and C(sp)-N bond formation of one carbon of isocyanides with thiophenols or disulfides or diselenides and azazoles simultaneously.

Virtual reality in post-stroke neurorehabilitation - a systematic review and meta-analysis.

Background: Stroke is a neurological disorder and one of the leading causes of disability worldwide. The patient may lose the ability to adequately move the extremities, perceive sensations, or ambulate independently. Recent experimental studies have reported the beneficial influence of virtual reality training strategies on improving overall functional abilities for stroke survivors.

Successive waves of COVID 19: confinement effects on virus-prevalence with a mathematical model.

Background: A pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (COVID 19) incidence data are largely available online. Until August 17, COVID 19 has hit more than 22 million individuals all over the globe. So, it is urged to get clear information about the prevalence of the virus.

Fustin Ameliorates Elevated Levels of Leptin, Adiponectin, Serum TNF-α, and Intracellular Oxidative Free Radicals in High-Fat Diet and Streptozotocin-Induced Diabetic Rats.

Fustin is a prominent ingredient of Stokes (Anacardiaceae) and has a wide range of pharmacological and clinical effects. The present study attempted to evaluate the antidiabetic potential of fustin in streptozotocin- and high-fat diet-induced diabetes in rats. The efficacy of fustin 50 mg/kg and 100 mg/kg/day p.

Fatal disseminated pyogenic infection due to hypermucoviscous hypervirulent Klebsiella pneumoniae: A case report and literature review.

Hypervirulent Klebsiella pneumonia is becoming recognized globally and has been associated with serious sequelae including death. However, ethnicity and metastatic infections are characteristics for hypermucoviscous hypervirulent Klebsiella pneumoniae (hvKp) and should be rolled in/out by PCR and/or string test.

Dietary management and growth outcomes in children with propionic acidemia: A natural history study.

Background: Propionic acidemia (PROP) is an autosomal recessive inherited deficiency of propionyl-CoA carboxylase (PCC) which is involved in the catalytic breakdown of the amino acids valine, isoleucine, methionine, and threonine. PROP nutritional management is based on dietary protein restriction and use of special medical formulas which are free of the offending amino acids, but are enriched in leucine. The resulting imbalance among branched-chain amino acids negatively impacts plasma concentrations of valine and isoleucine, which might impact growth in children with PROP.

Strigol1/albumin/chitosan nanoparticles decrease cell viability, induce apoptosis and alter metabolomics profile in HepG2 cancer cell line.

Hepatocellular carcinoma is one of the most common causes of cancer-related deaths globally. Bioavailable, effective and safe therapeutic agents are urgently needed for cancer treatment. This study evaluated the metabolomics profiling, anti-proliferative and pro-apoptotic effects of strigol/albumin/chitosan nanoparticles (S/A/CNP) on HepG2 cell line.

MEASUREMENT OF RADIATION DOSE TO THE EYE LENS IN NON-ENHANCED CT SCANS OF THE BRAIN.

Radiation can have undesirable effects on the eye, including a gradual loss of vision. Unnecessary radiation can reach the eye lens during non-enhanced computed tomography (CT) scans of the brain. The International Commission on Radiological Protection states the threshold for acute and chronic eye lens exposure is 500 mGy and the equivalent dose limit for the eye lens for public exposure is 15 mSv per year.

Beckwith-Wiedemann syndrome with macroglossia as the most significant manifestation: A case report.

Beckwith-Wiedemann syndrome is a complex multisystem disorder that requires collaboration of medical and dental teamfor its diagnosis and management. We present a dental overview and an update of the clinical and molecular diagnoses of Beckwith-Wiedemann syndrome and its management with emphasis on macroglossia.

Prevalence of COVID-19 antibodies among operating room and critical care staff at a tertiary teaching hospital: A cross-sectional study.

Objectives: To identify the prevalence of COVID-19 antibodies among operating room and critical care staff.

Methods: In this cross-sectional study, we recruited 319 Healthcare workers employed in the operation theater and intensive care unit of King Abdulaziz University Hospital (KAUH), a tertiary teaching hospital in Jeddah, Saudi Arabia between August 9, 2020 and November 2, 2020. All participants completed a 20-item questionnaire on demographic data and COVID-19 risk factors and provided blood samples.

Achieving high circularly polarized luminescence with push-pull helicenic systems: from rationalized design to top-emission CP-OLED applications.

While the development of chiral molecules displaying circularly polarized luminescence (CPL) has received considerable attention, the corresponding CPL intensity, hardly exceeds 10 at the molecular level owing to the difficulty in optimizing the key parameters governing such a luminescence process. To address this challenge, we report here the synthesis and chiroptical properties of a new family of π-helical push-pull systems based on carbo[6]helicene, where the latter acts as either a chiral electron acceptor or a donor unit. This comprehensive experimental and theoretical investigation shows that the magnitude and relative orientation of the electric ( ) and magnetic (μ ) dipole transition moments can be tuned efficiently with regard to the molecular chiroptical properties, which results in high values, up to 3-4 × 10.

Molecular control over vitrimer-like mechanics - tuneable dynamic motifs based on the Hammett equation in polyimine materials.

In this work, we demonstrate that fine-grained, quantitative control over macroscopic dynamic material properties can be achieved using the Hammett equation in tuneable dynamic covalent polyimine materials. this established physical-organic principle, operating on the molecular level, one can fine-tune and control the dynamic material properties on the macroscopic level, by systematic variation of dynamic covalent bond dynamics through selection of the appropriate substituent of the aromatic imine building blocks. Five tuneable, crosslinked polyimine network materials, derived from dianiline monomers with varying Hammett parameter () were studied by rheology, revealing a distinct correlation between the value and a range of corresponding dynamic material properties.

Escherichia coli expression and characterization of α-amylase from Geobacillus thermodenitrificans DSM-465.

Alpha amylase, catalyzing the hydrolysis of starch is a ubiquitous enzyme with tremendous industrial applications. A 1698 bp gene coding for 565 amino acid amylase was PCR amplified from Geobacillus thermodenitrificans DSM-465, cloned in pET21a (+) plasmid, expressed in BL21 (DE3) strain of E. coli and characterized.