Postnatal Toxicity in Mice Attributable to Plastic Leachables in Peritoneal Dialysis Solution (PDS).

Peritoneal dialysis solution (PDS), widely used to treat uremia and renal failure, may contain toxicants that have leached from their plastic storage bags. In this study, PDS was administered intraperitoneally (i.p.

Silicone rubber nipples: effects of sesame-oil extract on reproduction in mice.

The authors investigated a type of silicone rubber (SR) nipple for toxicity, caused by chemical migrants, on reproduction and pregnancy outcomes. They followed an extraction method (set forth in the 20th revised edition of the United States Pharmacopeia) in which sesame oil was a vehicle. They prepared the extract daily and administered it orally (50 ml/kg of body weight) into pregnant Swiss albino mice from gestation Day 0 until delivery.