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Br J Psychiatry
January 2019
Professor of Mood Disorders,Department of Psychological Medicine,Institute of Psychiatry,Psychology and Neuroscience, King's College LondonandSouth London and Maudsley National Health Service Foundation Trust,UK.
Background: Depression is considered to have the highest disability burden of all conditions. Although treatment-resistant depression (TRD) is a key contributor to that burden, there is little understanding of the best treatment approaches for it and specifically the effectiveness of available augmentation approaches.AimsWe conducted a systematic review and meta-analysis to search and quantify the evidence of psychological and pharmacological augmentation interventions for TRD.
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