806 results match your criteria: "Kidwai Memorial Institute of Oncology[Affiliation]"

Background: miRNAs play a critical role in the progression of various diseases, including oral squamous cell carcinoma (OSCC), which represents a major health concern and is one of the leading causes for new cancer cases worldwide. The miRNA dysregulation causes havoc and could be attributed to various factors, with epigenetic silencing of tumor suppressor genes being a major contributor to tumorigenesis. In this study, we have explored the tumor suppressive role of miR-198 in OSCC.

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  • * Conducted in early 2022 with 29 patients, the study found a high SLN identification rate of 93.1% and an overall accuracy of 96.3%, indicating the method's reliability.
  • * The research highlights that the depth of tumor infiltration is a critical predictor of nodal involvement, suggesting that SLNB could be a useful method for assessing neck status in early-stage buccal mucosal SCC.
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Unmasking Infection Risks in Multiple Myeloma: Insights from a Retrospective Analysis.

Indian J Hematol Blood Transfus

October 2024

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Dr. M H Marigowda Rd., Hombegowda Nagar, Bengaluru, Karnataka 560029 India.

Multiple myeloma (MM) has witnessed significant therapeutic advancements through the introduction of proteasome inhibitors and immunomodulators, leading to improved treatment outcomes. However, infections remain a formidable challenge for MM patients. The objective of our research is to investigate the factors that can forecast infection risk in MM patients.

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  • - The MONARCH plus study found that adding abemaciclib to endocrine therapy significantly improved progression-free survival (PFS) and objective response rate (ORR) in postmenopausal women with HR+/HER2- advanced breast cancer.
  • - In the study, cohort A (no prior systemic therapy) showed a median PFS of 28.27 months for abemaciclib users compared to 14.73 months for those on placebo, while cohort B (progression on prior therapy) showed 11.41 months vs. 5.59 months, respectively.
  • - Although abemaciclib was associated with some adverse events, they were manageable, and it demonstrated a trend toward overall survival (OS
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Spindle cell sarcoma (SCS) is a malignancy, with the most recent Surveillance, Epidemiology, and End Results (SEER) data citing a total of 250 reported cases occurring in the head and neck. Of these cases, none originated in the maxillofacial hard tissue. The diagnosis of SCS requires its differentiation from other sarcomas and spindle cell neoplasms.

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Lymph node metastasis is one of the most important prognostic factors in oral squamous cell carcinoma. In early stage oral cancers, Depth of invasion (DOI) is a predictor for lymph node metastasis. The aim of this study was to evaluate if DOI 4 mm can be considered as a threshold for clinical decision making on elective neck dissection (END) in early oral cancer, by assessing the association of DOI and the risk of occult lymph node metastasis in early Oral squamous cell carcinoma (OSCC).

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Unlabelled: The implications of extranodal extension (ENE) in oral carcinoma have been often related to prognosis and survival rates. The clinicopathologic predictive factors of this established prognostic factor were analyzed in this retrospective study. A total of 358 medical records of a single institution were screened.

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  • This study focuses on validating beam data from three beam-matched linear accelerators (LAs) for accurate radiation delivery in fractionated stereotactic treatment, comparing measured data to vendor reference data.
  • Measurements included percentage depth dose, beam profiles, output factors, and dynamic multi-leaf collimator factors for different photon types, achieving high accuracy with gamma analysis above 97%.
  • Quality assurance for eighty patient-specific plans showed median passing rates of over 76% to 98% across various gamma criteria, indicating compatibility of treatment across the beam-matched LAs without the need for re-planning.
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Endometrial cancer is one of the major cancers in women throughout the world. If diagnosed early, these cancers are treatable and the prognosis is usually good. However, one major problem in treating endometrial cancer is accurate diagnosis and staging.

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Orbital metastasis is a rare entity in oncology. With increasing awareness and advancement, patients with initial ocular presentation can be diagnosed and treated. Ocular metastasis is more common in breast cancer followed by lung cancer.

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Background: EBT-XD film specially designed for high dose verifications such as stereotactic treatments. The dose response of the film can be affected by several factors, the curly nature of the film being one of them. In this study this curly nature of the film was investigated for stereotactic body radiotherapy (SBRT) plan verifications.

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Aim: This study aims to validate the Razor Nano Chamber (RNC) and Razor Chamber (RC) dosimetric characteristics in a small field. The dosimetric parameters of the two chambers were compared.

Materials And Methods: The chamber characteristics of leakage (pre and post), stability, energy dependency, dose linearity, dose rate effect, stem effect, angular dependency, ion recombination effect, and polarity effect were studied.

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A Surgical Experience of Oral Squamous Cell Carcinoma Co-Existing with Post Burn Contractures of Neck.

Indian J Otolaryngol Head Neck Surg

August 2024

Dept of Oral Oncology, Kidwai Memorial Institute of Oncology, MH Marigowda Road, Hosur Road, Bengaluru, 560029 India.

A female patient in her early 60s was diagnosed with squamous cell carcinoma of right buccal mucosa. Interestingly, the patient also presented with post-burn contractures of face, neck and chest which posed significant anaesthetic and surgical challenges, thus making this case report unique. Through this case report, we highlight the reflections in management of such a case.

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Introduction: Thyroid nodules pose a frequent clinical dilemma, requiring the use of precise and expedient diagnostic methods. The effectiveness of the Thyroid Imaging Reporting and Data System (TIRADS) in relation to histopathology, which is considered the standard method, continues to be a prominent area of investigation. TIRADS provides a systematic evaluation based on ultrasound imaging.

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Background: After improvement in the treatment of oral cancers over the years we now see more patients with recurrent oral squamous cell carcinoma (OSCC) and second primary. Recommendations for addressing the neck (ipsilateral and/or contralateral) in these patients are still unclear and debatable.

Methods: In this retrospective study we included patients with recurrent and second primary OSCC who underwent surgery between January 2016 and December 2021.

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