6 results match your criteria: "Kidney Cancer Program at Simmons Comprehensive Cancer Center[Affiliation]"
Article Synopsis
- Sarcomatoid dedifferentiation occurs in various renal cell carcinoma subtypes, including chromophobe RCC, leading to more aggressive disease and resistance to treatments, but increased response to immunotherapy.
- Research on ChRCC reveals that it can dedifferentiate into sarcomatoid, anaplastic, and glandular forms, which are all linked to enhanced aggressiveness and metastasis.
- Key mutations, like those in TP53 and PTEN, drive this dedifferentiation process, and specific genetic and molecular markers could help classify and diagnose these aggressive tumors more effectively.
Understanding Factors that Influence Prognosis and Response to Therapy in Clear Cell Renal Cell Carcinoma.
Adv Anat Pathol
March 2024
Department of Pathology.
In this review, we highlight and contextualize emerging morphologic prognostic and predictive factors in renal cell carcinoma. We focus on clear cell renal cell carcinoma (ccRCC), the most common histologic subtype. Our understanding of the molecular characterization of ccRCC has dramatically improved in the last decade.
View Article and Find Full Text PDFRecent Advances in Renal Tumors with TSC/mTOR Pathway Abnormalities in Patients with Tuberous Sclerosis Complex and in the Sporadic Setting.
Cancers (Basel)
August 2023
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB T2L 2K5, Canada.
Article Synopsis
- - Recent research has identified a range of renal tumors linked to the TSC/mTOR pathway, including types like renal cell carcinoma with fibromyomatous stroma and eosinophilic solid and cystic renal cell carcinoma.
- - These tumors often exhibit unique physical and biochemical characteristics that allow for easy identification, reducing the need for detailed molecular testing.
- - The report highlights the latest findings and the growing complexity in understanding these renal tumor types.
Predicting Oncologic Outcomes in Small Renal Tumors.
Eur Urol Oncol
December 2022
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Kidney Cancer Program at Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:
Background: Most patients diagnosed with renal cancer today present with small renal masses (SRMs). Although these patients have a low risk of dying from their disease and many are followed with active surveillance protocols, a small subset of renal cell carcinomas (RCCs) behave aggressively. Knowledge regarding features of aggressive behavior would enable better adoption of active surveillance strategies among these patients.
View Article and Find Full Text PDFGermline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney.
Mod Pathol
March 2022
Kidney Cancer Program at Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Low-grade oncocytic tumor (LOT) of the kidney is a recently described entity with poorly understood pathogenesis. Using next-generation sequencing (NGS) and complementary approaches, we provide insight into its biology. We describe 22 LOT corresponding to 7 patients presenting with a median age of 75 years (range 63-86 years) and male to female ratio 2:5.
View Article and Find Full Text PDFRecent advances in molecular genetics have expanded our knowledge of renal tumors and enabled a better classification. These studies have revealed that renal tumors with predominantly "eosinophilic/oncocytic" cytoplasm include several novel biological subtypes beyond the traditionally well-recognized renal oncocytoma and an eosinophilic variant of chromophobe renal cell carcinoma. Herein, we present a comprehensive review of the eosinophilic vacuolated tumor (EVT) building upon a case report including radiology, histopathology, electron microscopy, and next-generation sequencing.
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