Practices of trauma-informed learning and their influence on the level of situational and personal anxiety of students who are studying face-to-face during hostilities.

Objective: Aim: To reveal the essence of trauma-informed learning in the context of the functioning of a person's inner world and the impact on changing the levels of situational and personal anxiety.

Patients And Methods: Materials and Methods: The study involved 900 people who are pursuing higher education during the military operations on the territory of Ukraine. Two parts of the Spielberger State-Trait Anxiety Inventory (STAI) questionnaire were used to determine low, medium, and high levels of situational and personal anxiety.

Significance of oxidative stress in liver damage of male and female rats with simulated ethanol hepatitis.

Objective: Aim: to find out the gender characteristics of oxidative mechanisms of liver damage in rats with ethanol hepatitis (EH).

Patients And Methods: Materials and Methods: The study was performed on 48 white male and female rats: 1 - control, 2 - acute EH (12,5 ml/kg of a 40% ethanol solution prepared on 5% solution of glucose for 7 days).The diene and triene conjugates (DC, TC), Schiff's bases (SB), TBA-active products (TBA-ap), activity of superoxide dismutase (SOD) and catalase (CAT) were determined in the blood serum.

Low anterior resection syndrome in distal rectal cancer patients and its correction methods.

Objective: Aim: To evaluate and compare the functional outcomes and quality of life in distal rectal cancer patients after low anterior resection with the formation of a transverse double-fold reservoir (TDFR) and without it.

Patients And Methods: Materials and Methods: The retrospective study enrolled 80 patients with distal rectal cancer: 40 patients who underwent low anterior resection with the formation of a TDFR, and 40 patients with the formation of a colorectal anastomosis (control group). The follow-up period was 10-60 months, with a median follow-up of 36 months after primary surgery.

Periodontitis upon hypothyroidism of young people.

Objective: Aim: To study the periodontal tissues and to establish the Magnesium content in oral liquid and capillary blood of young people with hypothyroidism from areas with Iodine deficiency.

Patients And Methods: Materials and Methods: In order to study the prevalence of periodontal disorders there were 330 people aged from 25 to 44 years from areas with natural Iodine deficiency enrolled in this examination. Primary hypothyroidism was diagnosed in 195 people (they made up the group I), and 135 people did not have any accompanying endocrine pathology (group II).

Characteristics of therapeutic and diagnostic errors in the management of traumatic brain injury by healthcare professionals: insights from forensic medical examinations on the quality of medical care.

Objective: Aim: To identify defects in the diagnosis and treatment of traumatic brain injury (TBI) committed by medical personnel at various stages of providing medical care based on the results of forensic medical examinations.

Patients And Methods: Materials and Methods: The article based on the study of medical care defects in cases of TBI. The research was conducted according to the data of forensic medical examinations by the SI "Main Bureau of Forensic Medical Examination of the Ministry of Health of Ukraine" from 2012 to 2021.

Assessment of society's readiness for the legalization of euthanasia, carried out in the field of palliative medicine.

Objective: Aim: To determine the signs of society's readiness to legalize euthanasia for palliative patients by interviewing both the patients themselves and their relatives (caregivers) and specialists who provide medical, psychological, social and spiritual services at the end-of-life.

Patients And Methods: Materials and Methods: The study was carried out using a sociological method among palliative patients of three regions of Ukraine (Lviv, Kyiv and Kharkiv) on a random sample of 377 people surveyed during 2022-2024. The conducted research confirmed and clarified the previous results with greater reliability.

Kallikrein-kinin system pathogenetic importance in experimental benign prostatic hyperplasia.

Objective: Aim: To analyze the mechanisms of regulation of the body's proteolytic systems during inflammation, detection of inflammation markers in blood and prostate secretions in the experimental benign prostatic hyperplasia in rats.

Patients And Methods: Materials and Methods: The study was conducted on 30 male rats on the model of benign prostatic hyperplasia. Rats were randomized as following: the 1st group (n=6) - intact animals; the 2nd group (n=24) - rats with benign prostatic hyperplasia.

A nickel implant induces cell death through autophagy in the connective tissue capsule in an experimental model.

Objective: Aim: To identify cellular autophagy markers around nickel-containing implant as evidence of metal hypersensitivity reactions in an animal model.

Patients And Methods: Materials and Methods: Rats were sensitized to nickel using a modified model involving the administration of NiSO4 with adjuvants. Subsequently, nickel plate implants (Ni content at 98.

Problems of harmonization of the criminal legislation of the certain continental law countries to ensure the protection of the circulation of medicinal products.

Objective: Aim: To find out the problems of the harmonization of the criminal legislation of the certain continental law countries to ensure the protection of the circulation of medicinal products.

Patients And Methods: Materials and Methods: This study is based on the analysis of the international legal acts, in particular, the Directives of the EU, as well as Medicrime Convention, national acts of criminal legislation of the certain continental law countries (Germany, Austria, Switzerland, Ukraine, etc.), national judicial practice, data on the number of criminal proceedings in the courts of Ukraine, criminal and medical law legal doctrine (38 normative legal acts and 15 court judgments), data of the Office of the Prosecutor General of Ukraine.

The effect of cell therapy on the intensity of lipid peroxidation processes in the liver, kidneys and lungs of rats of different ages under conditions of experimental cranio-skeletal trauma.

Objective: Aim: To determine the effect of cell therapy on the intensity of lipid peroxidation processes in the liver, kidneys and lungs of rats of different ages under conditions of experimental cranio-skeletal trauma (CST).

Patients And Methods: Materials and Methods: In the experiments, 129 white male Wistar line rats of different age groups were used: immature rats aged 100-120 days and weighing 90-110 g; mature rats aged 6-8 months and weighing 180-200 g; and old rats aged 19-23 months and weighing 300-320 g. In each age group, CST was modeled under thiopental sodium anesthesia.

Optimization of Radiology Diagnostic Services for Patients with Stroke in Multidisciplinary Hospitals.

Background: Effective radiology diagnostic services are crucial for the timely and precise diagnosis and treatment of stroke, a medical emergency, in multidisciplinary hospitals. However, the efficiency of these services might be impeded by various logistical and operational challenges present in a multidisciplinary hospital setup.

Objective: This review endeavours to explore the ways for optimizing stroke management in multi-disciplinary hospitals, delving into its benefits, current challenges, and future prospects.

Cardiorenal outcomes associated with sodium-glucose co-transporter-2 inhibitors in chronic kidney disease stage 5 (CKD V): A propensity score-matched analysis.

Background: There remains a paucity of data regarding the cardio-renal benefits of sodium-glucose co-transporter-2 inhibitors (SGLT2i) in patients with chronic kidney disease stage 5 (CKD V) based on major clinical trials.

Objective: This retrospective study aimed to identify potential cardiovascular and renal outcomes associated with SGLT2i use in CKD V patients.

Methods: We queried the TriNetX Global collaborative network from Jan 2014 - Aug 2023 for patients ≥18 years diagnosed with CKD V but not on dialysis.

Support needs of Ukrainian healthcare workers during wartime: A study on trust, legal security, and labor union involvement.

Background: As Ukraine enters its third year of war with Russia, healthcare workers (HWs) continue to face significant challenges. This study aimed to evaluate Ukrainian HWs' involvement in and trust in labor unions, assess their perceptions of social and legal security in the workplace, and identify the support they need.

Methods: An anonymous online survey of HWs included both closed-ended and open-ended questions.

Insights into pubertal development: a narrative review on the role of epigenetics.

Purpose: Puberty is a key phase of growth and development, characterized by psychophysical transformations. It is driven by a combination of genetic, hormonal, and environmental variables. Epigenetic mechanisms, including histone post-translational modifications and chromatin remodeling, microRNAs, and DNA methylation, play important roles in orchestrating the developmental processes.

The impact of 3-sulfo-taurolithocholic acid on ATPase activity in patients' colorectal cancer and normal colon tissues, and its hepatic effects in rodents.

Colorectal cancer is influenced by genetic mutations, lifestyle factors, and diet, particularly high fat intake, which raises bile acid levels in the intestinal lumen. This study hypothesized that bile acids contribute to tumorigenesis by disrupting ion transport and ATPase activity in the intestinal mucosa. The effects of 3-sulfo-taurolithocholic acid (TLC-S) on ATPase activity were investigated in colorectal cancer samples from 10 patients, using adjacent healthy tissue as controls, and in rodent liver function.

Investigation of the prevalence of latent tuberculosis in cancer patients compared to non-cancer patients: a case-control study.

Background: Latent tuberculosis (TB) can reactivate in immunocompromised individuals, such as cancer patients undergoing chemotherapy, leading to severe complications. Understanding the prevalence of latent TB in this high-risk group is crucial, especially in regions with moderate to high TB burdens.

Aim: This study aims to determine the prevalence of latent tuberculosis in cancer patients before chemotherapy and immunotherapy to guide preventive interventions and reduce the risk of TB reactivation.

Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights.

Thromboembolic disorders, including deep vein thrombosis (DVT) and pulmonary embolism (PE), are major global health concerns, causing significant morbidity and mortality. Early diagnosis is crucial for effective treatment and improved patient outcomes. Recent research has identified Apelin-13, a bioactive peptide in the apelin family, as a promising diagnostic biomarker for Thromboembolic disorders.

TB treatment delays and associated risk factors in Dushanbe, Tajikistan, 2019-2021.

Background: In Tajikistan, where there are about 8,000 cases annually, many new cases are being diagnosed with severe disease, indicating a delay in receiving care. We aimed to estimate the proportion with delayed care and the main factors contributing to delayed care.

Methods: Using a retrospective cohort design, we conducted a study that included all people aged over 15 years who were newly diagnosed with pulmonary TB in Dushanbe from 2019 to 2021.

Prevalence of hepatitis B surface antibody among previously vaccinated healthcare workers in Tashkent, Uzbekistan.

Healthcare workers (HCW) have high occupational risk for hepatitis B and Uzbekistan held two HCW vaccination campaigns in 2015 and 2022. Hepatitis B antibody testing (anti-HBs) after Hepatitis B (HepB) vaccination is recommended by the U.S.

Occupational safety of healthcare workers in the terms of the Covid-19 pandemic as the public health aspect.

Objective: Aim: To assess the level of occupational safety, health and hygiene of healthcare workers in the terms of the COVID-19 pandemic..

Patients And Methods: Materials and Methods: bibliosemantic, bibliographic, analytical, statistical methods as well as a systemic approach have been used in the research.

Assessment of the workload of general practitioners in outpatient clinics in Almaty.

Objective: Aim: The purpose of this study is to comprehensively assess the workload of general practitioners using the time study and the WISN method..

Patients And Methods: Materials and Methods: Time studies are used to assess the objective workload of physicians, by measuring the duration of physicians' activities, and the WISN method, which is based on the workload of a health care professional and determines how many health care professionals of a certain type are needed to cope with the workload of a given health care facility.

The modern view of the use of extracorporeal detoxification in the treatment of drug poisoning (overdose).

Objective: Aim: To analyze the results of the application of extracorporeal detoxification methods in the treatment of drug poisoning and their complications..

Patients And Methods: Materials and Methods: The studied data of 129 patients aged 18-46 years with severe drug poisoning treated at the Kyiv toxicological center in 2010-2020.