[Methodical approach to studying quality life of patients which underwent plastic operation].

The obtained results of the study are based on observation of life quality of 98 patients which have undergone traditional and combined operation. The article presents quality life indices of healthy subjects and those operated. Traditionally operated patients were established to have lower quality life indices in 6 years after the operation provided in comparison with healthy subjects.

[Endoscopic method of the face rejuvenation].

Technical aspects of endoscopic aesthetic interventions, conducted in 65 patients with various signs of early ageing of the face and neck tissues and aesthetic defects in 1996-2005 yrs, are stated. In general four types of endoscopic operations were performed: complete (subperiostal) lifting of forehead, the forehead and middle zone of face lifting, the forehead and face lifting, cervicoplasty, the forehead lifting and the twoplane lifting of face. There were presented possible complications of endoscopic operations, which are less frequent and severe than after performance of open interventions.

[Combined cosmetic operation of the face].

The method of performance of combined cosmetic operation in 58 women patients in 1996-2005 yrs. was analyzed. As a primary procedure for rejuvenation the combined operation of the face and neck skin lifting permits to achieve impressive results, prevents the "lateral bend" and hollow eyes formation.

[Frequencies of Y chromosome binary haplogroups in Belarussians].

The compositions and frequencies of Y-chromosome haplogroups identified by genotyping 23 biallelic loci of its nonrecombining region (YAP, 92R7, DYF155S2, 12f2, Tat, M9, M17, M25, M89, M124, M130, M170, M172, M174, M173, M178, M201, M207, M242, M269, P21, P25, and P37) have been determined in a sample of 68 Belarussians. Eleven haplogroups have been found in the Belarussian gene pool (E, F*, G, I, I1b, J2, N3a*, Q*, R1*, R1a1, and R1b3). Haplogroup R1a1 is the most frequent; it includes 46% of all Y chromosomes in this sample.

4-Hydroxy-1-methyl-2-oxo-N-(4-oxo-2-propyl-3,4-dihydroquinazolin-3-yl)-1,2-dihydroquinoline-3-carboxamide.

The two bicyclic fragments of the title compound, C(22)H(20)N(4)O(4), are individually planar and are turned with respect to each other by 77.8 (2) degrees. The formation of intramolecular O-H.

[Structure of the gene pool of eastern Ukrainians from Y-chromosome haplogroups].

Y chromosomes from representative sample of Eastern Ukrainians (94 individuals) were analyzed for composition and frequencies of haplogroups, defined by 11 biallelic loci located in non-recombining part of the chromosome (SRY1532, YAP, 92R7, DYF155S2, 12f2, Tat, M9, M17, M25, M89, and M56). In the Ukrainian gene, pool six haplogroups were revealed: E, F (including G and I), J, N3, P, and R1a1. These haplogroups were earlier detected in a study of Y-chromosome diversity on the territory of Europe as a whole.

[Effect of parental age on endoreduplication of giant chromosomes and some quantitative traits in Drosophila melanogaster descendants].

We studied the influence of parental age on the degree of polyteny of giant chromosomes and expressivity of mutation eyeless in Drosophila melanogaster descendants. The parental age equal to six days exerted an adverse effect on the function of endoreduplication of giant chromosomes in strain eyeless. The highest degree of polyteny was observed in descendants of four- and ten-day imago.

[MtDNA and Y-chromosome lineages in the Yakut population].

The structure of female (mtDNA) and male (Y-chromosome haplotypes) lineages in the Yakut population was examined. To determine mtDNA haplotypes, sequencing of hypervariable segment I and typing of haplotype-specific point substitutions in the other parts of the mtDNA molecule were performed. Y haplogroups were identified through typing of biallelic polymorphisms in the nonrecombining part of the chromosome.

[Pluripotency of bone marrow stromal cells and perspectives of their use in cell therapy].

The possibility of differentiation of insulin-producing cells and neural and glial elements was demonstrated in the culture of bone marrow stromal cells. The perspectives of use of the bone marrow stromal cells in clinical medicine are considered.

Morphofunctional changes in the pineal gland during dynamic adaptation to hypothermia.

The effects of stress induced by hypothermia (+4 degrees C for 3 h) on the pathways of serotonin metabolism in the pineal gland and on its structure were studied in adult male Wistar rats. These experiments showed that the melatonin-forming function of the epiphysis undergoes phasic changes during adaptation: there was a significant increase during the first 15 min, which was followed by gradual inhibition (to initial by 30 min) and then sharp suppression (at 3 h). Suppression of the functional activity of the pineal gland occurred because of exclusion of a proportion of pinealocytes from the process of active functioning.

Heme oxygenase activity and some indices of antioxidant protection in rat liver and kidney in glycerol model of rhabdomyolysis.

Activity of heme oxygenase, superoxide dismutase, and catalase, the content of reduced glutathione and total heme in the liver and kidneys, and serum absorption spectrum in the Soret band were studied in rats with glycerol-induced rhabdomyolysis. Glycerol increased the content of heme-containing metabolites in the serum and the total heme content in the liver and kidneys, and decreased the content of reduced glutathione and catalase activity in the examined organs. Superoxide dismutase activity increased in the liver and decreased in the kidneys.

[Apollinariĭ Grigor'evich Podrez, professor of surgery in the Khar'kov university ( on 150th anniversary of the birthday)].

The article is devoted to an outstanding surgeon of the late XIXth century Professor A. G. Podrez.

[Structural and functional changes in various cells following radiation exposure].

Structural and functional changes in thymocytes, splenocytes and hepatocytes, taking place under gamma-irradiation of cellular suspensions were investigated. It was found that splenocytes begin to lose their functional activity and structural features at a dose of 2 Gy. Increasing the irradiation dose leads to the acceleration of these processes.

[Haplotype of Y-chromosomes in the Central Asia population].

The distribution of alleles and haplotypes of three diallellic Y-specific loci (YAP, DYF155S2, and Tat) in the populations of Kyrgyz, Uzbeks and Tajiks was analyzed. In Kyrgyzes and Uzbeks, a relatively high frequency of the DYF155S2 deletion (20 and 12.5%, respectively) and the C allele at the Tat locus (11.

Microcirculatory disturbances in gastric mucosa during ulcer disease and effects of serotonin on their dynamics.

Experiments on rat model of stress-induced gastric ulcers revealed marked circulatory disturbances in ulcerated gastric mucosa associated with arteriolar spasm and venous congestion and leading to perivascular edema, diapedesis of erythrocytes, and microhemorrhages. These changes were most pronounced on day 1 after ulcer modeling and progressively decreased during healing (day 14-21). On day 3, arterial hyperemia developed against the background of venous congestion, which was probably related to progressive repair.

[Radiation-induced changes in the structure of erythrocyte membrane proteins].

Structural changes in proteins of erythrocyte membranes induced by gamma-radiation at doses of 10-10(3) Gy were studied using the method of tryptophan fluorescence quenching by acrylamide. It was found that the exposure to ionizing radiation leads to a decrease in intramolecular dynamics of membrane proteins.

[The prevention of HIV/AIDS among injection drug abusers and women in the sex business in the city of Kharkiv].

A steady increase of the number of persons with drug addiction has been noted both on Kharkov and Kharkov Province. Since 1996 a considerable number of HIV-infected persons has been detected among injecting drug users (80-82% of them infected parenterally). Rapid evaluation, carried out in 1997 within the project "Harm Reduction", served as the basis for the creation of the Charity Fund "Scarlet Ribbon" collaborating with the UNAIDS Representation in the Ukraine and other international organizations.

[Genetic demographic processes in Ukrainian population in 1990. The marriage structure of the Donetsk population].

Analysis of records of the marriages that were contracted in the city of Donetsk revealed that, between 1960 and 1992, the marriage rate in the city decreased from 14.8 to 4.7 per 1000 people, the migration rate (m) decreased from 0.

[Genetic-demographic processes in urban populations of the Ukraine in the 90's. The marital structure of the Poltava population].

Analysis of records of the marriages that were contracted in the city of Poltava revealed an increase in outbreeding between 1960 and 1985 in the Poltava population. This was expressed in increased ethnic diversity, proportion of interethnic marriages, migration range, and the parent-offspring and average marital distances, whereas the proportion of the indigenous ethnic group (Ukrainians) decreased. By 1995, outbreeding decreased: the ethnic composition of the population became more homogeneous (98% Slavic), the proportion of Ukrainians and the frequency of monoethnic marriages increased, and the migration range decreased.

[The current aspects of the pharmacological correction of hyperglycemia in patients with non-insulin-dependent diabetes mellitus (type 2)].

Data on the mechanisms of developing of hyperglycemia in patients with diabetes mellitus (type 2) are analyzed and reviewed. The current concept of hypoglycemic therapy aimed both at amelioration of hyperglycemia symptoms and reduction of the risk of diabetic micro- and macroangiopathies is considered. The main directions of pharmacological action of hypoglycemic drugs (both in use and in the stage of design) and data of the efficiency and possible incidental action are presented.

[Effect of culture density and degree of expression of the trait "eyeless" and degree of polyteny of giant chromosomes in Drosophila melanogaster].

Effects of culture density on expressivity of character eyeless and polyteny of giant chromosomes were studied in Drosophila melanogaster. Larval crowding was shown to significantly reduce eye facets. The expression of eyeless was sex-dependent: in females, this character was expressed more strongly than in males.

[The effect of altan on the functional activity of the liver mitochondria and microsomes from rats with toxic hepatitis].

In in vitro experiments althan had no effect on the respiration of intact mitochondria in state 4 according to Chance and produced a high antioxidant effect in fermentative and ascorbate-dependent lipid peroxidation in intact microsomes isolated from the rat liver. In ethanol-induced toxic hepatitis althan restored the functional activity of mitochondria to the level of that in intact animals and increased microsome hydroxylase activity in CCl4-hepatitis.

[Interaction of Ag+ ions with ribonucleotides of canonical bases].

The interaction of Ag+ ions with ribonucleotides of canonical bases in aqueous solution was studied by differential UV spectroscopy. Atoms coordinating silver ions (N7, O6 of guanosine 5'-monophosphate, N3, O2 of cytidine 5'-monophosphate, N7, N1, N3 of adenosine 5'-monophosphate and N3 of uridine 5'-monophosphate) and the binding constants characterizing the formation of appropriate complexes were determined. The differences in the relative affinity of Ag+ ions for the atoms of nucleotide bases correlate with the potential on them.

[The hepatoprotective action of ellagotannins].

The hepatoprotective properties of altan (obtained on the basis of ellagotannines from the cones of black alder Alnus glutinosa) are studied on the model of acute damage to the liver with tetrachloromethane. It is found that altan exhibits the hepatoprotective activity even in a dose of 1 mg/kg which is tenfold smaller compared to the dose of traditional flavonoid-based drugs. Altan limits choleopoiesis disorder, has an antiinflammatory and membrane stabilizing effect, and recovers physiological antioxidant system.

[Genetic-demographic processes in urban populations of the Ukraine in the 1990's. Marriage structure of the Kharkov population].

The characteristics of marriages contracted in 1993 in two districts of the city of Khar'kov were studied. The age, education, occupation, ethnicity, and birthplace of the spouses were recorded. The genetic demographic parameters of the marriage structure were compared to the results of a similar study performed in 1985.