6,427 results match your criteria: "Khalifa University of Science & Technology[Affiliation]"

Article Synopsis
  • The study focuses on how aging and loss of sex hormones affect vascular function in women, highlighting their increased risk for cardiovascular disease (CVD).
  • It found that older women show more significant impairment in lower limb conduit artery function compared to the upper limb.
  • Additionally, CVD risk factors, particularly related to lipid levels and insulin sensitivity, have a stronger association with upper limb microvascular function in older women.
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  • This study aimed to evaluate the effectiveness of ultrasound elastography compared to fine-needle aspiration cytology (FNAC) in diagnosing thyroid nodules as benign or malignant.
  • The research involved 360 patients with visible thyroid nodules and found that FNAC outperformed ultrasound elastography in terms of sensitivity (92.00%) and specificity (85.33%) for distinguishing benign nodules.
  • Ultimately, while ultrasound elastography showed potential with an accuracy of 81.94%, FNAC maintains its status as the gold standard with an accuracy of 85.47%, particularly across different age groups.
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We aimed at investigating the effect of different anionic polysaccharides (pectin, carboxymethylcellulose, and gum Arabic) on the physicochemical properties and stability of whey protein isolate (WPI)- stabilized solid-in-oil-in-water (S/O/W) bilayer emulsions loaded with epigallocatechin gallate (EGCG). S/O/W emulsions were prepared by homogenizing EGCG-loaded oil with an aqueous phase containing WPI and the selected polysaccharides. The emulsions were characterized for their particle size, zeta potential, microstructure, and rheological properties.

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Worldwide, stroke is a leading cause of long-term disability in adults. Alteplase is the only approved treatment for acute ischemic stroke (AIS) and results in an improvement in a third of treated patients. Most studies evaluated the post-alteplase haemorrhagic transformation of brain infarction as a homogeneous entity but we evaluated the predictors of each subtype of haemorrhagic transformation of brain infarction.

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Gallium-doped zinc oxide (GZO) has demonstrated significant potential in gas-sensing applications due to its enhanced electrical and chemical properties. This study focuses on the synthesis, characterization, and gas-sensing performance of GZO nanoparticles (NPs), specifically targeting CO₂ detection, which is crucial for environmental monitoring and industrial safety. The GZO samples were synthesized using a sol-gel method, and their crystal structure was determined through X-ray diffraction (XRD), confirming the successful incorporation of gallium into the ZnO lattice.

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This work uses the polymeric reduction method to explore the in-situ synthesis of gold nanoparticles (AuNPs) within 3D-printed optical fiber probes (OFPs). Digital light processing (DLP) 3D printing is employed to fabricate the OFPs using a resin consisting of hydroxyethyl methacrylate (HEMA) and polyethylene glycol diacrylate (PEGDA). After printing, OFPs were immersed in a boiling gold precursor solution to facilitate the synthesis of AuNPs inside the polymer matrix.

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Article Synopsis
  • * The study found that using vermicompost with bio-stimulants, particularly moringa leaf extract (MLE), greatly enhanced wheat growth, yield, and nutrient absorption, outperforming other organic options.
  • * The combination of vermicompost and MLE increased plant height, leaf area, and photosynthesis, leading to significant rises in both straw (64%) and grain (27%) yields compared to control groups, highlighting a promising sustainable approach for farmers.
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This study examined the effect of triple-frequency ultrasound treatment (TFUT)-assisted lactic acid bacteria (LAB-L. plantarum and L. helveticus fermentation for 24-h and 48-h) on the chemical, structural, morphological, metabolic, and sensory properties of rice lees (RL).

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  • A study was conducted to explore syphilis prevalence among migrant craft and manual workers (MCMWs) in Qatar, which make up 60% of the population, focusing on both lifetime and recent infections.
  • Analysis involved sera specimens collected during a nationwide SARS-CoV-2 seroprevalence survey, utilizing advanced testing methods to detect syphilis antibodies and recent infections.
  • Results showed a lifetime syphilis infection rate of 1.3% and a recent infection rate of 0.09%, with higher infection prevalence noted in older age groups and variations based on nationality and occupation.
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Proteomics analysis of extracellular vesicles for biomarkers of autism spectrum disorder.

Front Mol Biosci

November 2024

Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by symptoms that include social interaction deficits, language difficulties and restricted, repetitive behavior. Early intervention through medication and behavioral therapy can eliminate some ASD-related symptoms and significantly improve the life-quality of the affected individuals. Currently, the diagnosis of ASD is highly limited.

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Background: RSV is a common seasonal cause of respiratory infections in children and potentially adults and is considered a major cause of mortality and morbidity. While several studies on RSV have been conducted in Saudi Arabia, none have specifically focused on the southwestern region, where distinct climatic and demographic factors may influence RSV pattern. The current study aims to describe five years of experience with RSV cases among hospitalized patients and factors associated with intensive care admission from a tertiary hospital.

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Cervical cancer is the second most common cancer in women's bodies after breast cancer. Cervical cancer develops from dysplasia or cervical intraepithelial neoplasm (CIN), the early stage of the disease, and is characterized by the aberrant growth of cells in the cervix lining. It is primarily caused by Human Papillomavirus (HPV) infection, which spreads through sexual activity.

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Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.

Immunity

December 2024

Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW 2052, Australia; Clinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, NSW 2010, Australia. Electronic address:

Article Synopsis
  • T follicular helper (Tfh) cells, which are important for antibody production, rely heavily on the immunoreceptor PD-1, and its deficiency leads to weakened Tfh functions and impaired immune responses in mice.
  • Individuals lacking PD-1 or PD-L1 demonstrate fewer memory B cells and diminished antibody responses, highlighting the critical role of these molecules in immune system functionality.
  • PD-1 influences both the intrinsic and extrinsic aspects of B cell memory and antibody production, suggesting that disruptions in PD-1 signaling can lead to complications in immune responses, especially during anti-PD-1-PD-L1 therapies.
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Hepatic peliosis in a newborn - A case report and review of the literature.

Int J Surg Case Rep

December 2024

Department of Neonatal Resuscitation Unit, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and. Health (UM6SS), Casablanca, Morocco; Department of Neonatal Resuscitation Unit, Mohammed VI International University Hospital, Mohammed VI University of Sciences and Health, Casablanca, Morocco.

Article Synopsis
  • Hepatic peliosis is a rare condition in which blood-filled spaces develop in the liver, often going unnoticed until autopsy; a case of a newborn with abdominal distension led to its discovery.
  • The newborn, just one day old, was found to have hepatomegaly and multiple blood cavities in the liver, confirmed through imaging and biopsy.
  • The only potential risk factor identified was the mother's use of antihistaminic drugs during pregnancy, suggesting a possible but unexplained link to this uncommon condition in neonates.
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DNA damage underlies the progression of asthma toward a severe, steroid hyporesponsive phenotype. The accumulation of double-stranded DNA within the cytosol triggers the activation of cytosolic DNA-sensing pathways, notably the Stimulator of Interferon Genes (STING) pathway. However, the precise role of STING in driving steroid hyporesponsiveness remains elusive and warrants further investigation.

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Catamenial hemothorax is a rare manifestation of thoracic endometriosis, characterized by blood in the pleural cavity associated with menstrual cycles. We present the case of a 42-year-old woman with recurrent right-sided chest pain and dyspnea coinciding with menstruation. Imaging revealed a large pleural effusion and hemothorax.

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Role of macroscopic on-site evaluation of endoscopic ultrasound-guided fine-needle aspiration/biopsy: Results of a multicentric prospective study.

World J Gastrointest Endosc

November 2024

Department of Gastroenterology and Endoscopy Center, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health, Casablanca 82403, Casablanca-Settat, Morocco.

Article Synopsis
  • The study evaluates the effectiveness of macroscopic on-site evaluation (MOSE) during endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/FNB) in diagnosing solid lesions, particularly focusing on histological core sample adequacy.
  • Conducted across 16 medical centers in Egypt, Iraq, and Morocco, the study involved over 1000 patients and revealed that a significant majority of biopsied samples were adequate for histological evaluation, demonstrating a high diagnostic yield.
  • Results indicated that FNB needles performed best in terms of sensitivity and sample quality, highlighting the potential of MOSE as a valuable alternative to traditional rapid on-site evaluation methods.
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Article Synopsis
  • - The study investigates the gut and skin microbiome of young children with food allergies (FA), discovering that they exhibit greater bacterial diversity compared to non-allergic kids over time.
  • - Researchers analyzed samples from 23 children with newly diagnosed IgE-mediated FA, finding a significant correlation between higher total IgE levels and certain bacterial genera related to the number of allergies, particularly with tree nut and peanut allergies.
  • - These results enhance the understanding of microbiome dynamics in food-allergic children and suggest the potential role of specific bacterial genera as biomarkers for certain food allergies.
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Probiotic and Rice-Derived Compound Combination Mitigates Colitis Severity.

Pharmaceuticals (Basel)

October 2024

Biological Science Department, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi Arabia.

Article Synopsis
  • This study explored how () and Hasawi rice protein lysate (HPL) can help reduce colitis, an inflammatory condition of the colon, induced in mice by DSS.
  • Researchers evaluated various factors such as disease activity index (DAI), gut permeability, and antioxidant enzyme activity to determine the effectiveness of the treatments.
  • Results showed that the combination of both treatments significantly improved symptoms, reduced oxidative stress, and lower pro-inflammatory markers, indicating that () with HPL could be a promising approach for managing colitis.
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The presence of -, , gene family has been reported in many important plants, playing roles in various aspects of plant biology but little has been uncovered in soybeans. Soybean is one of the major plants providing nutrition for humans and livestock globally. In this study, we overexpressed a novel gene () in and conducted bioinformatic analyses, evaluated the T2 transgenic line in an open field, and applied major stressors along with the growth promoter GA to investigate the potential functions of the gene.

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Metallic nanoparticles have found wide applications due to their unique physical and chemical properties. Green biosynthesis using plants, microbes, and plant/microbial extracts provides an environmentally friendly approach for nanoparticle synthesis. This review discusses the mechanisms and factors governing the biosynthesis of metallic nanoparticles such as silver, gold, and zinc using various plant extracts and microorganisms, including bacteria, fungi, and algae.

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Background: Loquat fruit is consumed for its flavorful taste and a rich array of health-promoting compounds like phenolics, flavonoids, and carotenoids. This study aimed at the biochemical characterization of fresh juice from the Moroccan variety of loquat and evaluating its effects on lipid homeostasis and liver steatosis in hyperlipidemic mice.

Methods: The biochemical characterization followed AOAC methods.

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Alzheimer's disease treatment landscape: current therapies and emerging mechanism-targeted approaches.

Neural Regen Res

November 2024

Department of Anesthesiology, Pharmacology and Therapeutics, and Djavad Mowafaghian Center for Brain Health, University of British Columbia, Vancouver, BC, Canada.

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The naked-eye detection of hazardous pollutants through simple and cost-effective techniques is of great interest to the scientific community and related stakeholders in analytical science. The present study emphases the development of a stimuli-responsive probe by encountering sophisticated techniques for the detection of environmental pollutants. Herein, highly swellable and fluorescent-WTR-CDs-loaded HB-Alg/Gel@WTR-CDs was fabricated through a simple extrusion dripping method.

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