62 results match your criteria: "Khairpur Medical College[Affiliation]"

Diabetes mellitus (DM) is a long-term metabolic disorder caused by inadequate production and resistance to insulin. The prevalence of DM is rapidly increasing, with type 2 diabetes (T2D) accounting for more than 90% of cases. Despite new treatments, many patients with T2D do not meet their glycemic targets due to clinical inertia.

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  • - Scheie syndrome is a rare, milder form of mucopolysaccharidosis type I, which primarily affects multiple organ systems and is rarely linked to cancer, with only one prior case of associated brain tumors reported almost 30 years ago.
  • - The case presented involves a 10-year-old girl diagnosed with Scheie syndrome, who also developed a brain tumor identified through MRI as a pilocytic astrocytoma, a rare type of brain tumor found in the fourth ventricle.
  • - This situation emphasizes the need for careful evaluation of children with mucopolysaccharidoses for potential brain tumors, particularly when they exhibit signs of increased intracranial pressure, as early detection can prevent serious neurological issues.
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  • Atrial fibrillation (AF) is a common heart rhythm disorder in the U.S. that affects millions, and it can lead to serious complications like rapid ventricular response (RVR).
  • An umbrella review of existing systematic reviews found IV diltiazem was more effective than IV metoprolol for controlling heart rate and reducing ventricular rates in patients experiencing AF with RVR.
  • However, the use of IV diltiazem was also associated with a higher risk of hypotension, indicating the need for further research to evaluate the balance between efficacy and safety for these treatments.
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  • This review synthesizes data from multiple systematic reviews and meta-analyses to evaluate the safety and effectiveness of high-power, short-duration (HPSD) ablation compared to low-power, long-duration (LPLD) methods.
  • The findings indicate that HPSD ablation significantly lowers AF recurrence rates and reduces the risk of esophageal thermal injury, making it a safer and more efficient treatment option.
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Background/aim: Probiotics are live microbial supplements that improve the microbial balance in the host animal when administered in adequate amounts. They play an important role in relieving symptoms of many diseases associated with gastrointestinal tract, for example, in necrotizing enterocolitis (NEC), antibiotic-associated diarrhea, relapsing Clostridium difficile colitis, Helicobacter pylori infections, and inflammatory bowel disease (IBD). In this narrative review, the authors aim to evaluate the role of different probiotic formulations in treating gastrointestinal diseases in pediatric population aged 18 years or younger and highlight the main considerations for selecting probiotic formulations for use in this population.

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Aims: Approximately 55% of patients diagnosed with primary or metastatic cancer endure pain directly attributable to the disease. Consequently, it becomes imperative to address pain management through a comparative analysis of stereotactic radiotherapy (SRT) and conventional radiation therapy (CRT), especially in light of the less efficacious improvement achieved solely through pharmacological interventions.

Materials And Methods: A systematic exploration was undertaken on PubMed, the Cochrane Library, and Elsevier's ScienceDirect databases to identify studies that compare Stereotactic Radiotherapy to Conventional radiation therapy for pain management in individuals with metastatic bone cancer.

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This study presents a case of a living liver donor who developed a hepatitis E virus (HEV) infection postdonation, complicating his recovery. The donor was a 28-year-old male with no prior health issues who underwent a right lobe hepatectomy. Initially, his postoperative course was uneventful, but on the third postoperative day, he became lethargic and icteric.

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  • The research emphasizes the need for a multidisciplinary approach to address the challenges of neuropsychiatric illnesses, linking neurology and psychiatry based on shared neurobiological and genetic factors.
  • It critiques traditional diagnostic frameworks that struggle to differentiate between neurological and psychiatric issues, affecting diagnosis and treatment plans.
  • The study advocates for improved collaboration between neurologists and psychiatrists, exploring both pharmacological and non-pharmacological treatment strategies for a more integrated care model.
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Molnupiravir is incorporated into the viral genome, thereby increasing errors, mismatching, and misdirecting the viral polymerase thereby, halting viral RNA replication of SARS-CoV-2. Following PRISMA guidelines, a thorough literature search was performed on electronic and medical databases from December 2022 till January 2023. Molnupiravir 800 mg showed significance in creating viral RNA error rate at Day 5 (WMD: 4.

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In May 2019, the U.S. Food and Drug Administration approved tafamidis as the first conservative management of transthyretin amyloid cardiomyopathy (ATTR-CM).

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Hepatitis is often called a 'silent killer' as most patients remain asymptomatic and hence remain unaware of their illness. They are either diagnosed incidentally or get symptomatic when their illness advances years after getting the infection. In Pakistan, transmission has increased due to ignorance of sterilization techniques, sharing personal items, and unsafe healthcare practices and the burden of liver cancers and transplants has risen three-fold during the past 20 years.

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Patients unlikely to obtain deceased donor liver transplantation (DDLT) are offered living donor liver transplantation (LDLT) as an alternative. The success of LDLT is bound to the availability of altruistic donors who undergo smooth and safe surgery. Donor morbidity is reported to be up to 20-30%, while donor mortality is only 0.

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Objective: The study aims to discuss the assessment methods used for the incidence of in-hospital postoperative delirium (IHPOD) in transcatheter aortic valve replacement (TAVR) patients and explore possible strategies for preventing and reducing postoperative complications in the geriatric population.

Methodology: An electronic search of PubMed, Embase, BioMedCentral, Google Scholar, and the Cochrane Central Register of Controlled Trials was conducted up to August 2021, to identify studies on the IHPOD following TAVR in patients above 70 years. The primary objective of the study was to determine the incidence of delirium following TAVR and procedures like transfemoral (TF) and non-TF approaches.

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Neonatal jaundice is a common illness that affects around 80% of preterm and 50-60% of full-term newborn infants. It is one of the most common causes of neonatal death. Neonatal jaundice may be physiological or pathological.

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Background: Hypercholesterolemia is a lipid disorder characterized by excessively high levels of low-density lipoproteins, which encourages fat accumulation in your arteries, hence escalating the chances of heart attack and stroke. Globally, 39% of individuals experience elevated total cholesterol levels with 98.6 million DALYs (disability-adjusted life years) caused by high non-HDL cholesterol in 2019, supposedly killing 4.

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Domperidone is an antagonist of the peripheral dopamine (D2) receptor. It works as an antiemetic by blocking D2-receptors at the chemoreceptor trigger zone and as a gastroprokinetic drug by blocking GI tract D2-receptors. According to research, using domperidone significantly raises the risk of cardiac arrhythmia and sudden cardiac death by 70%, most likely through prolonging the QT interval.

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A rise in the incidence of water-borne, communicable illnesses, and viral outbreaks in Pakistan follows periods of heavy rainfall. Due to climate change, floods and droughts have had devastating effects on human health by facilitating the spread of infectious illnesses including cholera, malaria, typhoid, dengue fever, and viral hepatitis A. Food instability, starvation, malnutrition, and a lack of potable water are only some of the indirect effects of flooding on health.

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Recent outbreak of diphtheria in Pakistan; short communication.

Ann Med Surg (Lond)

June 2023

Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.

Diphtheria, a vaccine-preventable bacterial infection caused by usually starts with sore throat and fever and often results in breathing difficulties, heart rhythm problems, and rarely membranous pharyngitis. Although nursing these complications can help most people survive diphtheria, but it can be deadly in 5-10% of cases with higher death rates observed in children under 5 years of age or adults above 40. For the year 2022, 92 cases have been reported by seven European countries.

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Introduction: Transplantation in many Asian countries is moulded by socioeconomic, religious, cultural and health indicators. In most Asian countries, the living-related donation is the common most organ donation. Due to the limited deceased organ donation, live donor programmes flourished in many Asian countries.

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Foodborne illness is caused by the intake of food and water contaminated by different bacteria, viruses, and parasites, as well as poisons or toxins. Approximately 31 different pathogens are documented as causative organisms for causing foodborne illness outbreaks. Climatic changes and varying agricultural practices contribute significantly to the increased incidence of foodborne illness.

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