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The effect of 6-mercaptopurine on early human placental explants.

Hum Reprod

May 2005

Oncogenetic laboratory, Department of Medicine A, Sapir Medical Center, Kfar-Saba 44281 Tel-Aviv University, Israel.

Article Synopsis
  • 6-mercaptopurine (6-MP) is an immunosuppressive drug linked to negative pregnancy outcomes, such as low birth weight and fetal malformations, especially in the first trimester.
  • Human placental explants exposed to 6-MP showed reduced migration and proliferation of extravillous trophoblast (EVT) cells, alongside increased apoptosis, compared to control samples.
  • Despite these cellular changes, 6-MP did not significantly affect hormone levels within the placental explant cultures.
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