5 results match your criteria: "Key Laboratory of Second Affiliated Hospital of Kunming Medical University[Affiliation]"
ICP22-defined condensates mediate RNAPII deubiquitylation by UL36 and promote HSV-1 transcription.
Cell Rep
October 2024
Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China; KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China. Electronic address:
Article Synopsis
- * The viral protein ICP22 creates a specialized area (VICE domain) that aids in managing RNAPII through a process called liquid-liquid phase separation.
- * A specific function of the virus's UL36 protein helps protect RNAPII from degradation, ensuring continued viral gene expression even when host transcription is inhibited.
Persistent inflammation and neuronal loss in the mouse brain induced by a modified form of attenuated herpes simplex virus type I.
Virol Sin
February 2023
Key Laboratory of Second Affiliated Hospital of Kunming Medical University, Kunming, 650000, China. Electronic address:
Herpes simplex virus-1 (HSV-1) is a widespread neurotropic virus that can reach the brain and cause a rare but acute herpes simplex encephalitis (HSE) with a high mortality rate. Most patients present with changes in neurological and behavioral status, and survivors suffer long-term neurological sequelae. To date, the pathogenesis leading to brain damage is still not well understood.
View Article and Find Full Text PDFCohesin promotes HSV-1 lytic transcription by facilitating the binding of RNA Pol II on viral genes.
Virol J
January 2021
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.
Background: Herpes Simplex Virus type I (HSV-1) is a large double-stranded DNA virus that enters productive infection in epithelial cells and reorganizes the host nucleus. Cohesin, a major constituent of interphase and mitotic chromosomes comprised of SMC1, SMC3, and SCC1 (Mcd1/Rad21), SCC3 (SA1/SA2), have diverse functions, including sister chromatid cohesion, DNA double-stranded breaks repair, and transcriptional control. Little is known about the role of cohesin in HSV-1 lytic infection.
View Article and Find Full Text PDFCorrection to: Longitudinal transcriptomic characterization of viral genes in HSV-1 infected tree shrew trigeminal ganglia.
Virol J
October 2020
Key Laboratory of Animal Models and Human Disease Mechanism of the Chinese Academy of Science/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.
An amendment to this paper has been published and can be accessed via the original article.
View Article and Find Full Text PDFLongitudinal transcriptomic characterization of viral genes in HSV-1 infected tree shrew trigeminal ganglia.
Virol J
July 2020
Key Laboratory of Animal Models and Human Disease Mechanism of the Chinese Academy of Science/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.
Background: Following acute infection, Herpes Simplex virus-1 (HSV-1) establishes lifelong latency and recurrent reactivation in the sensory neurons of trigeminal ganglia (TG). Infected tree shrew differs from mouse and show characteristics similar to human infection. A detailed transcriptomic analysis of the tree shrew model could provide mechanistic insights into HSV-1 infection in humans.
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