Novel insights on the biology and immunologic effects of histamine: A road map for allergists and mast cell biologists.

Histamine (CHN, molecular weight 111.15 g/mol) is a well-studied endogenous biogenic amine composed of an imidazole ring attached to an ethylamine side chain. It has a limited half-life of a few minutes within tissues and in circulation.

The associations between dietary omega-6, omega-3, and omega 6 to omega 3 ratio fatty acids and hypertension risk among adults: A prospective cohort study.

Background And Aims: Previous studies have yielded mixed results on the connection between dietary omega-3 and omega-6 intakes and the risk of hypertension (HTN) incidents. Therefore, we conducted a study to survey the connection between baseline dietary intake of omega-3, omega-6, and omega-6 to omega 3 (omega-6/3) fatty acids (FA) and the risk of hypertension.

Methods: We conducted a prospective cohort study and assessed dietary intake through a 118-item food frequency questionnaire (FFQ).

The sexual dysfunction in women with thyroid disorders: a meta-analysis.

Background: Thyroid disorders are common endocrine conditions impacting multiple organs, including the reproductive system and often lead to sexual dysfunction. These effects can vary by gender; for example, women with hypothyroidism frequently experience reduced libido. Low thyroid hormone levels are also linked to vaginal dryness, causing discomfort, especially during intercourse.

The effect of educational intervention through sending emails on improving physical posture in female computer users of Eastern Iran: a quasi-experiment study.

Background: Musculoskeletal disorders are among the most common occupational injuries and disabilities in developing and industrialized countries. This study aims to determine the effectiveness of e-mail training to improve the physical posture of female computer users at Birjand University of Medical Sciences in Iran.

Methods: The present interventional research explores the effect of email-based training to correct the body posture of female computer users in Birjand, Iran.

The effects of prune products consumption on anthropometric measurements and blood pressure in adults: A systematic review and dose-response meta-analysis.

Introduction: The positive impact of prunes on body measurements and blood pressure has been suggested in previous research.

Purpose: The purpose of this extensive meta-analysis and systematic review was to examine the effects of adult consumption of prunes on anthropometric parameters and blood pressure.

Methods: To identify relevant randomized controlled trials (RCTs) (till August 9th, 2024), databases from ISI Web of Science, Scopus, and PubMed/Medline were searched.

Distribution of Virulence-Associated and Aminoglycoside Resistance Genes Among Clinical Isolates of in the Southeast of Iran, During 2019-2023: A Cross-Sectional Study.

Background And Aims: (), included in the World Health Organization's list of critical priority pathogens, is considered a serious threat to public health. The present study aims to investigate the prevalence of virulence-associated and aminoglycoside resistance genes in clinical isolates of .

Methods: This cross-sectional study was carried out on 88 clinical isolates of .

Machine learning based algorithms for virtual early detection and screening of neurodegenerative and neurocognitive disorders: a systematic-review.

Background And Aim: Neurodegenerative disorders (e.g., Alzheimer's, Parkinson's) lead to neuronal loss; neurocognitive disorders (e.

Investigation of adherence to DASH diet components and reduction of heart failure risk in adults: A case-control study.

Background: Heart failure (HF), or congestive Heart failure (CHF), is a heart disorder with a number of symptoms caused by the heart's inability to pump blood. Our aim in conducting this study is to investigate the adherence to dietary approaches to stop hypertension (DASH) diet components and the risk of HF in Iranian adult women and men.

Methods: In this hospital-based, case-control study, we included 340 participants (194 men and 146 women) aged 30-70 years who were recently (less than 6 months) diagnosed with HF.

Healthcare utilization among people with disabilities in Iran: what predictors are associated with medical visits?

Background: Ensuring equitable access to healthcare services for individuals with disabilities poses a significant challenge for healthcare systems. This research aimed to explore the factors affecting medical visits among this population.

Method: This cross-sectional study in Iran involved data from 766 adults with disabilities aged 18 and older.

Systematic review of neurofeedback interventions for dyslexia: Methodological insights and International Classification of Function and Disability-Child and Youth (ICF-CY) framework analysis.

Purpose: The present study is a systematic review aimed at examining the impact of neurofeedback interventions on the body structure and function, as well as the activity and participation of children with developmental dyslexia, in accordance with the International Classification of Functioning, Disability, and Health-Children and Youth version.

Method: Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, databases including Scopus, Cochrane, Science Direct, PubMed, and Google Scholar were searched using keywords such as "Neurofeedback," "Dyslexia," and related terms based on Mesh terms, without any time restrictions, until January 2024. The inclusion criteria were clinical experimental and randomized controlled trials that investigated the impact of neurofeedback in children with reading and writing disorders, and their full-text articles were available in English or Persian.

Psychometric properties of Persian version of health literacy for Iranian school-age children scale.

Health literacy may play an important role in the attainment of the United Nations Sustainable Development Goals. The aim of this study was to assess the psychometric properties of the Persian version of Health Literacy for School-Aged Children (P-HLSAC) employing data that covered the entire school path. This cross-sectional study was conducted in 2023-24 among 605 school-aged students in Isfahan, Iran.

Green synthesis of magnesium oxide nanoparticles using the extract of to enhance the healing of burn wounds.

Treating burn lesions has always been challenging because any product should be cheap, accessible, and have anti-bacterial commodities and tissue regeneration properties. The green synthesis of magnesium oxide nanoparticles (GS-MgONPs) can create an optimal prospect that is safe with low toxicity in biological tissue and better safety for application while including the antibacterial effect. This recent study aimed to evaluate the effectiveness of burn wound treatment using GS-MgONPs in rats.

Unraveling the interplay of CD8 + T cells and microRNA signaling in cancer: implications for immune dysfunction and therapeutic approaches.

MicroRNAs (miRNAs) emerge as critical regulators of CD8 + T cell function within the complex tumor microenvironment (TME). This review explores the multifaceted interplay between miRNAs and CD8 + T cells across various cancers. We discuss how specific miRNAs influence CD8 + T cell activation, recruitment, infiltration, and effector function.

Telomerase-based vaccines: a promising frontier in cancer immunotherapy.

Telomerase, an enzyme crucial for maintaining telomere length, plays a critical role in cellular immortality and is overexpressed in most cancers. This ubiquitous presence makes telomerase, and specifically its catalytic subunit, human telomerase reverse transcriptase (hTERT), an attractive target for cancer immunotherapy. This review explores the development and application of telomerase-based vaccines, focusing on DNA and peptide-based approaches.

Global prevalence of constipation during pregnancy: a systematic review and meta-analysis.

Background: Constipation is a common complication and an unpleasant experience during pregnancy. Due to hormonal factors, intestinal movements decrease during this time, causing the digestive system to malfunction. This study aims to explore the worldwide prevalence of constipation during pregnancy to prevent and minimize its complications.

Comparison of oral zinc supplement and placebo effect in improving the T-cells regeneration in patients undergoing autologous hematopoietic stem cell transplantation: Clinical trial study.

Background: Immune reconstitution is a significant factor in the success of "hematopoietic stem cell transplantation" (HSCT). Delaying the immune reconstitution increases the risk of infections and relapse after transplantation. T-cell recovery after HSCT is mainly thymus-dependent, and thymic atrophy is associated with various clinical conditions that correlate with HSCT outcomes.

The Effect of Green-Synthesized Nanoparticles on Dental Caries-Causing Bacteria: A Systematic Review.

Introduction: In this study, a comprehensive search was conducted across multiple databases, including PubMed, Google Scholar, SID, Scopus, Medline, and Web of Science, as well as selected herbal medicine journals. The inclusion of herbal medicine journals was justified by the growing interest in green-synthesized nanoparticles derived from plant extracts, which are relevant to the focus of this review. Articles published between 2015 and 2023 were evaluated.

Does lower limb kinesio taping affect pain, muscle strength, and balance following fatigue in healthy subjects? A systematic review and meta analysis of parallel randomized controlled trials.

Background: Kinesio tape (KT) has gained popularity in sports and rehabilitation due to its ease of use and potential benefits. However, its effectiveness is not well understood especially in addressing fatigue, a condition that can impair muscle function and increase the musculoskeletal risk of injury. Given KT's potential impact on muscle activity and recovery, this review aims to evaluate the effects of lower limb KT on pain, strength, and balance following fatigue.

Exosomes and tissue engineering: A novel therapeutic strategy for nerve regenerative.

Damage to nerves negatively impacts quality of life and causes considerable morbidity. Self-regeneration is a special characteristic of the nervous system, yet how successful regeneration is accomplished remains unclear. Research on nerve regeneration is advancing and accelerating successful nerve recovery with potential new approaches.

Curcumin and exercise prevent depression alleviating hippocampus injury and improve depressive-like behaviors in chronically stressed depression rats.

Background And Purpose: Depression is a growing public health concern worldwide, characterized by cognitive impairment and structural abnormalities of the hippocampus. Current antidepressant treatment sometimes causes the late onset of results and the much faster occurrence of side effects. For this reason, the interest in new treatment strategies including exercise and natural products such as curcumin has increased to treat depression.

Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.

Background: There is no consensus in the existing literature regarding the effect of soluble fiber on the lipid profile of patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis of randomized controlled trials aimed to assess the effect of soluble fiber on triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in T2DM patients.

Methods: PubMed/MEDLINE, Scopus, and ISI Web of sciences were searched for RCTs up to 4 May 2024.

Distinct therapeutic effects of auraptene and umbelliprenin on TNF-α and IL-17 levels in a murine model of chronic inflammation.

Objective: To compare the anti-arthritic potential of orally administered auraptene (AUR) and umbellliprenin (UMB) in chronic inflammation by exploring the differential effect on regulating TNF-α and IL-17.

Methods & Materials: Sixty male rats were divided into ten groups, and after confirming chronic inflammation, the treatment groups received AUR or UMB orally for 9 days. On day 16, histopathological changes were evaluated.