The effect of trans-theoretical model stage-matched intervention on medication adherence in hypertensive patients.

Introduction: Hypertension is a chronic condition that requires active patient management and awareness of treatment strategies. This study aimed to evaluate the effectiveness of an intervention program grounded in the Transtheoretical Model (TTM) of behavior change for improving treatment adherence among hypertensive patients.

Materials And Methods: This study conducted at the Nukan Comprehensive Rural Health Center in Kermanshah, Iran, 120 participants were selected according to specific inclusion criteria.

Green synthesis of silver nanoparticles using Acroptilon repens aqueous extract and their antibacterial efficacy against multidrug-resistant Acinetobacter baumannii.

Background: Acinetobacter baumannii is a critical pathogen associated with hospital-acquired infections, particularly in burn and intensive care unit (ICU) patients, and is notorious for its high level of antibiotic resistance. This study aims to evaluate the antibacterial potential of silver nanoparticles (AgNPs) synthesized using Acroptilon repens extract as a promising alternative treatment for combating multidrug-resistant A. baumannii.

Green synthesis of ZnO nanoparticles: and assessment of anticancer and antibacterial activity and biomolecule (DNA) binding analysis.

The zinc oxide nanoparticles (ZnO NPs) were synthesized by a green chemistry approach utilizing Sosn.) (extract, aims to innovate by employing environmentally friendly techniques. The production of ZnO NPs was confirmed by FT-IR, zeta potential, TEM, SEM-EDX, DLS and ultraviolet-visible techniques.

Anti-neuropathic effects of astaxanthin in a rat model of chronic constriction injury: passing through opioid/benzodiazepine receptors and relevance to its antioxidant and anti-inflammatory effects.

Introduction: Neuropathic pain is a debilitating neurological disorder and is on the rise. Since no effective treatment has been so far approved to combat the complex pathological mechanisms behind neuropathic pain, finding new therapeutic candidates is of great importance. Astaxanthin (AST) is a carotenoid with strong antioxidant, and anti-inflammatory activities.

Preparation and characterization of oleo-gum-resin-loaded electrospun nanofibers and evaluating its wound healing activity in two rat models of skin scar and burn wound.

Background: A growing body of research is dedicated to developing new therapeutic agents for wound healing with fewer adverse effects. One of the proceedings being taken today in wound healing research is to identify promising biological materials that not only heal wounds but also vanish scarring. The effectiveness of nanofibers like polyvinyl alcohol (PVA), in improving wound healing can be related to their unique properties.

A comparison of the effects of ticagrelor and clopidogrel in patients with acute ST-segment elevation myocardial infarction: a systematic review and meta-analysis of randomized clinical trials.

Background: Rupture of unstable coronary atherosclerotic plaque leads to acute ST-segment elevation myocardial infarction (STEMI). Dual anti-platelet therapy is one of the main treatments, and the combination of Aspirin and Clopidogrel is recognized as the standard oral regimen in most cases. Ticagrelor is a new generation of P2Y12 receptor inhibitors.

Fat embolism following fat grafting: A systematic review of reported cases.

Background: This systematic review aims to consolidate and analyze reported cases of fat embolism following fat grafting, focusing on patient demographics, procedural characteristics, clinical features, diagnostic methods, management strategies, and outcomes.

Methods: A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines was conducted across multiple databases, including PubMed, Google Scholar, Cochrane, Embase, MEDLINE, and Scopus, up to January 31, 2024. Inclusion criteria encompassed case presentations diagnosing fat embolism or fat embolism syndrome post-fat grafting in patients over the age of 18 years.

Impact of bariatric surgery on infertility in obese women: a systematic review and meta-analysis.

Background: The prevalence of obesity is increasing worldwide, with several consequences, including reduced fertility in both men and women. One of the ways to reduce weight is bariatric surgery. The aim of this systematic review and meta-analysis study was to evaluate the effectiveness of bariatric surgery on weight loss and subsequent improvement of fertility in obese infertile women.

Biological activities of astaxanthin in the treatment of neurodegenerative diseases.

Introduction: Neurodegenerative diseases (NDs) develop with the gradual advancement of neuronal damage and dysfunction in the central nervous system (CNS). These disorders are mostly the outcomes of the improper sedimentation and accumulation of proteins, such as amyloid-β (Aβ), α-synuclein, and prions. Astaxanthin (AST) exists in different types of living organisms and displays antioxidant and anti-inflammatory functions.

Discovery of Sulfanilamide-diazo Derivatives Incorporating Benzoic Acid Moieties as Novel Inhibitors of Human Carbonic Anhydrase II Activity.

Background: Sulfonamides are widely used carbonic anhydrase inhibitors (CAIs) in clinical settings, however, their nonspecific inhibition of multiple carbonic anhydrase isoforms can lead to reduced efficacy and side effects. This study aimed to develop sulfanilamide-diazo derivatives incorporating benzoic acid moieties as novel inhibitors of hCA II activity to reduce side effects and enhance selectivity for different CA isozymes.

Methods: We investigated the interaction between these derivatives and the hCA II isozyme via various spectroscopic and docking methods.

Prevalence of thrombosis in patients undergoing dialysis treatment: A systematic review and meta-analysis.

Aim: to determine the prevalence of thrombosis in dialysis patients.

Background: Thrombosis is the most common cause of vascular access dysfunction in dialysis patients. Various studies have reported different prevalence rates of thrombosis, and no systematic study provides a comprehensive result on this subject.

Differential Expression of Neurodegeneration-Related Genes in SH-SY5Y Neuroblastoma Cells Under the Influence of Cyclophilin A: Could the Enzyme be a Likely Trigger and Therapeutic Target for Alzheimer's Disease?

The function and mechanism of Cyclophilin A (CypA) in modulating gene expression associated with Alzheimer's disease (AD) remain unclear. This multifunctional protein is found to be elevated in the cerebrospinal fluid (CSF) of individuals at risk for AD. The cytotoxic effects of CypA, including both wild-type and the mutant R55A, were assessed using the MTT assay.

The Importance of Stem Cells in the Treatment of Neuropathic Pain.

Many disorders, including heart, bone, cancer, liver, and brain disease, have been treated using stem cell therapy as a viable alternative. The somatosensory system is affected by a lesion, which leads to neuropathic pain (NP), and just a relatively tiny fraction of patients now receive effective care from existing pharmacological medications. There have been studies to show the effectiveness of various stem cells in reducing or treating experimental neurological pain, although these studies are uncommon in number.

The Association Between the C-Reactive Protein Gene Variants rs1130864 and rs2794521 and Obstructive Sleep Apnea in the Iranian Kurdish Population.

Obstructive sleep apnea (OSA) syndrome is a widespread multifactorial disorder that raises the risk of cardiovascular disease, diabetes, and Alzheimer's disease. This study aimed to investigate the association between the risk of OSA and two C-reactive protein (CRP) gene variants, rs1130864 and rs2794521. In this study, 100 patients and 100 controls participated.

Effect of deep diaphragmatic breathing on pain in patients with metastatic gastrointestinal cancers.

Background: Patients with gastrointestinal cancers commonly experience acute and chronic pain. This study aimed to determine the effect of deep diaphragmatic breathing on acute and chronic pain in patients with metastatic gastrointestinal cancers.

Methods: This clinical trial was conducted in Kermanshah-Iran in 2022.

Large Myxoid Ovarian Leiomyoma: A Case Report.

Ovarian leiomyoma is a rare, benign spindle cell tumor with a favorable prognosis. Myxoid leiomyoma, a rare subtype of leiomyoma, exhibits significant myxoid changes. We present a case study of a rare ovarian myxoid leiomyoma in a young woman.

A digital neuromorphic system for working memory based on spiking neuron-astrocyte network.

Among various types of memory, working memory (WM) plays a crucial role in reasoning, decision-making, and behavior regulation. Neuromorphic computing is a well-established engineering approach that offers promising avenues for advancing our understanding of WM processes by mimicking the structure and operation of the human brain using electronic technology. In this work, a digital neuromorphic system is proposed and then implemented in hardware to illustrate the real-time WM process based on the spiking neuron-astrocyte network (SNAN).

Association Between Noise-Induced Hearing Loss and Vestibular Dysfunction in Workers Chronically Exposed to Occupational Noise.

Background: Despite the understanding of the association between noise exposure and noise-induced hearing loss (NIHL), the effects of noise on vestibular function are less well understood and neglected.

Aim: The aim of this study was to investigate the function of the vestibular system in workers with NIHL.

Materials And Methods: Thirty male textile workers with symmetrical NIHL (49.

Carotid artery intima-media thickness in women with polycystic ovary syndrome: A cross-sectional study.

Background: Obesity in polycystic ovary syndrome (PCOS) may increase the risk of cardiovascular disease. Carotid intima-media thickness (CIMT) is an acceptable marker in assessing the risk of heart disease.

Objective: This study aimed to evaluate the CIMT in PCOS women compared to non-PCOS women.

Local Single-Dose Teriparatide Administration for BRONJ Prevention: Insights from a Rat Model Study.

Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) presents significant clinical challenges with uncertain treatment outcomes. Teriparatide, a fragment of human parathyroid hormone, shows potential in prevention strategies for BRONJ.

Objective: This study investigates the impact of a single local dose of teriparatide on BRONJ prevention in an animal model.

The effects of portfolio moderate-carbohydrate and ketogenic diets on anthropometric indices, metabolic status, and hormonal levels in overweight or obese women with polycystic ovary syndrome: a randomized controlled trial.

Background: Polycystic Ovary Syndrome (PCOS) is one of the most common hormonal disorders in reproductive-age women caused by hyperinsulinemia. The portfolio Moderate-carbohydrate diet (PMCD) is a plant-based diet with a carbohydrate content of 40% and incorporates five cholesterol-lowering foods. While, the ketogenic diet is a high-fat diet with 70% fat, promoting a ketosis state.

High-risk patient profiles for ovarian cancer: A new approach using cluster analysis of tumor markers.

Objective: Ovarian cancer remains a leading cause of cancer-related deaths in women. Early detection improves prognosis, but current diagnostic tools still need improvement. We aimed to identify high-risk patient profiles for ovarian cancer using cluster analysis of age and tumor marker data.

Coronary Artery Disease Empowerment Scale (CADES): Persian translation and psychometric properties.

Introduction: Coronary artery disease (CAD) is a leading cause of global mortality and a prevalent health issue in Iran. Assessing the empowerment of CAD patients during treatment and care is essential. However, no scale is available to measure empowerment in CAD patients in Iran.