Treatment of cancer-associated fibroblast-like cells with celecoxib enhances the anti-cancer T helper 1/Treg responses in breast cancer.

Tumor inflammation, as one of the hallmarks of cancer, has been the target for anti-cancer treatments. Celecoxib is a selective inhibitor of the enzyme cycloxygenase-2 (COX-2) and inhibits the production of PGE2, which is an important mediator of tumor inflammation produced by cancer cells and cells of the tumor microenvironment. In this study, we aimed at inhibiting COX-2 using celecoxib, expressed in cancer-associated fibroblast (CAF)-like cells isolated from breast cancer and evaluated the alterations in their cytokine profile and gene expression.

Innovative grey water treatment using eco-friendly bio-photocatalyst AgCuFeO@chitosan in the presence of synergistic effects of persulfate activation: optimization and mechanisms.

In this study, AgCuFeO@Chitosan bio-photocatalyst was synthesized to make the most of environmental benignity and chemical stability for advanced greywater applications. The photocatalyst was evaluated under UV irradiation by synergistic activation of persulfate. FESEM, EDS-Mapping, and BET analyses showed quasi-spherical nanoparticles with a homogeneous size distribution, homogenous elements dispersion, and 15.

Predictive utility of artificial intelligence on schizophrenia treatment outcomes: A systematic review and meta-analysis.

Identifying optimal treatment approaches for schizophrenia is challenging due to varying symptomatology and treatment responses. Artificial intelligence (AI) shows promise in predicting outcomes, prompting this systematic review and meta-analysis to evaluate various AI models' predictive utilities in schizophrenia treatment. A systematic search was conducted, and the risk of bias was evaluated.

The relationship between COVID-19 anxiety and self-efficacy among adolescent students: A cross-sectional study.

Background: The spread of the COVID-19 epidemic, as well as its high contagiousness, increased students' anxiety and stress. Anxiety may affect individuals' functioning and undermine their self-efficacy. Therefore, the present study aimed to determine the relationship between COVID-19 anxiety and self-efficacy among adolescent students.

Comparison of Gene Polymorphisms of ACE1 and ACE2 and the Level of Total ACE Activity in the Blood of Afghans and Iranians with COVID-19 and Its Relationship with Disease Severity.

Field evidence indicates differences in the rate and severity of COVID-19 infection among Afghans and Iranians, potentially influenced by individual genomic variances. Therefore, investigating the potential causes of these disparities holds significant clinical importance. This study aims to explore and compare variations in the genes encoding angiotensin-converting enzyme 1 (ACE1) and angiotensin-converting enzyme 2 (ACE2), along with total ACE activity levels in the blood of Afghans and Iranians with COVID-19, to assess any potential correlation with disease severity.

The Effect of Job Skills and Job Burnout on Job Satisfaction Among Health Information Management Staff.

Background And Aims: The health information management department faces multiple challenges such as multiple tasks, high workload, role ambiguity and conflict, and work pressure. In addition, informatics and health information technology tools are continuously used in this sector. Based on studies, the use of information technology affects job burnout and job satisfaction.

The effectiveness of an intervention using LAWE (loveliness and well-being of employees) app to improve the employee's mental well-being.

Background: Organizations are increasingly seeking comprehensive approaches to improve employee mental well-being (EMW). This study aims to evaluate the effectiveness of interventions delivered through the "Loveliness and Well-being of Employees" (LAWE) app, focusing on five key predictors: "Keep Learning," "Connect," "Take Notice," "Be Active," and "Given".

Methods: A quasi-experimental intervention was conducted with 110 participants (53 in the intervention group and 57 in the non-intervention group) from the Kerman University of Medical Sciences in Southeastern Iran.

Examining nurses' awareness level and compliance between defined and required access levels to core functionalities of hospital information system : an observational and survey study.

Background: Nurses constitute the largest number of hospital information system (HIS) users. Therefore, their awareness level and access to HIS functions based on their needs are particularly important. The present study aims to determine nurses' access levels to HIS functions and examine the compliance between defined and required access levels to core functionalities of a comprehensive HIS.

Facilitators of medication adherence in patients with hypertension: a qualitative study.

Hypertension has been identified as the most important risk factor for disability and premature death worldwide. This study aimed to explain the factors that facilitate medication adherence from the perspective of patients with hypertension in southeastern Iran. This qualitative study used conventional content analysis and purposive sampling methods to achieve data saturation, involving 25 participants.

Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects approximately 0.46% of the global population. Conventional therapeutics for RA, including disease-modifying antirheumatic drugs (DMARDs), nonsteroidal anti-inflammatory drugs (NSAIDs), and corticosteroids, frequently result in unintended adverse effects.

The psychometric assessment of the provider version of mHealth App Usability Questionnaire (MAUQ) in persian language.

Introduction: mHealth apps are widely utilized in healthcare. To guarantee their usefulness and usability, it is crucial to assess them using a reliable scale tailored specifically for mHealth apps and their users.

Objective: The aim of this study is the psychometric assessment of the provider version of mHealth App Usability Questionnaire (MAUQ) in Persian language.

Process and mechanism modeling of cefotaxime removal from hospital wastewater using pistachio shells based magnetic activated carbon nanoparticles.

Antibiotic residues have been extensively identified in diverse aquatic environments, posing significant health risks to both humans and animals, while also presenting challenges to the environment. Consequently, the imperative need to effectively removal antibiotics from the environment has become a very importance issue. In this study, response surface methodology with central composite design was employed to systematically investigate the effects of key process parameters, on the removal of cefotaxime (CTX) from hospital wastewater using pistachio sells based activated carbon modified with FeCl.

The Impact of Vitamin E Supplementation on Oxidative Stress, Cognitive Functions, and Aging-Related Gene Expression in Aged Mice.

This study investigated the effects of different doses of vitamin E on oxidative stress, cognitive function, and gene expression in aged mice. A total of 32 male mice, aged 12 months, were divided into a control group and three treatment groups. These groups received varying daily doses of vitamin E for a period of 28 days.

Oncoming Revolution in the Next Generation of Cohort Studies.

The world is changing rapidly, mainly due to the impact of megatrends that have an impact on the entire human life, particularly in medical sciences. Medical research methodologies such as cohort studies provide very critical information, but it is not clear what would be its destination in the future. In this short article, we have tried to offer a somewhat different perspective on the future of cohort studies by analyzing the texts and their conclusions from the author's viewpoint.

Fibroblast growth factor receptor 1 gene (FGFR1) amplification in non-small cell lung cancer (NSCLC) by real-time PCR.

Background: Comprehensive molecular assessment of cancers could open up new horizons for novel therapies. Fibroblast growth factor receptor 1 (FGFR1) gene amplification has been previously demonstrated in non-small cell lung cancer (NSCLC) patients. The current study aimed to evaluate the prevalence of FGFR1 gene amplification and its association with clinical and demographic data in a group of NSCLC patients.

Diagnostic accuracy of mean platelet volume in cirrhotic patients with spontaneous bacterial peritonitis presented to the emergency department.

Background: The aim of this study was to investigate the diagnostic accuracy of mean platelet volume (MPV) in predicting SBP in cirrhotic patients.

Methods: This was an observational, analytical, and retrospective study conducted on cirrhotic patients with abdominal ascites referred to the emergency department (ED) over a 1-year period. The cirrhotic patients with ascites were divided into two groups with or without SBP.

Effect of WhatsApp Messenger-based education on the knowledge of health ambassadors about home care for minor illnesses.

Background: In the digital era, virtual education has become one of the most effective educational methods, in which, the latest educational materials can be made available to people using social network platforms. Health ambassadors are mediators for transferring health-related knowledge to the public, so, they must be aware of various health topics, such as home care for minor illnesses. This study aimed to determine the effects of social media-based interventions (using WhatsApp) on the knowledge of health ambassadors concerning home care for minor illnesses.

Which criteria are important in usability evaluation of mHealth applications: an umbrella review.

Introduction: Usability plays a critical role in the design of mHealth applications. A well-designed app enhances user experience and contributes to better healthcare outcomes. However, it remains unclear which usability criteria are often neglected, leading to issues in the actual use of these applications.

Review on the role of hypothalamic astrocytes in the neuroendocrine control of metabolism.

Astrocytes are the most numerous type of glial cells found in the nervous system. They regulate energy homeostasis in collaboration with the neuronal circuits involved in energy balance. These glial cells are equipped with sensors and receptors for nutrients and metabolic hormones in order to control energy homeostasis.