Prevalence and associated factors of anxiety and depression among patients with hypothyroidism in Southern Iran.

Purpose: Depression and anxiety are the main disorders in patients suffering from hypothyroidism. These disorders can lead to increased patient suffering. Since hypothyroidism is one of the most prevalent endocrine diseases, controlling the metabolic variables that increase the severity of anxiety and depression is important.

Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies.

Leishmaniasis is a parasitic disease caused by protozoan organisms belonging to the Leishmania genus, affecting many individuals worldwide, with the burden surpassing one million cases. This disease leads to considerable morbidity and mortality, predominantly within tropical and subtropical regions. The current therapeutic options for leishmaniasis are far from ideal, as they fail to achieve a level of efficacy that can be deemed universally effective.

A Preliminary Study to Evaluate the Immune Response to a Booster Dose of the Adult Tetanus-Diphtheria Vaccine (Td) Available in Iran.

Background: Despite the availability of tetanus-diphtheria (TD) vaccines in Iran, the seroconversion rate of these products as a booster dose is unknown.

Objectives: This study evaluates the seroconversion rate of the Iranian Td vaccine in adults who have not been vaccinated in the past decade.

Methods: In this study, 20 adult volunteers aged 18 to 60 who had not received the Td vaccine in the past decade received a booster dose of the Iranian Td vaccine.

Recent advances on brain drug delivery via nanoparticles: alternative future materials for neuroscience applications; a review.

Essentially, the blood-brain barrier (BBB) serves as a line of demarcation between neural tissues and the bloodstream. A unique and protective characteristic of the blood-brain barrier is its ability to maintain cerebral homeostasis by regulating the flux of molecules and ions. The inability to uphold proper functioning in any of these constituents leads to the disruption of this specialized multicellular arrangement, consequently fostering neuroinflammation and neurodegeneration.

Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation.

Menopause is a natural biological aging process characterized by the loss of ovarian follicular function and decrease estrogen levels. These hormonal fluctuations are associated with increased iron levels, which ultimately lead to iron accumulation. This study aims to investigate the effects of Deferasirox on iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation.

Clinical and mechanistic insights into biomedical application of Se-enriched probiotics and biogenic selenium nanoparticles.

Selenium is an essential element with various industrial and medical applications, hence the current considerable attention towards the genesis and utilization of SeNPs. SeNPs and other nanoparticles could be achieved via physical and chemical methods, but these methods would not only require expensive equipment and specific reagents but are also not always environment friendly. Biogenesis of SeNPs could therefore be considered as a less troublesome alternative, which opens an excellent window to the selenium and nanoparticles' world.

"Clinical outcomes and healthcare costs in status epilepticus: A multivariable analysis from a tertiary center in a resource-limited setting".

Background: As a debilitating and severe repercussion, the clinical and economic impact of Status epilepticus (SE) has not been thoroughly explored in various regions around the world, especially those with limited resources. Therefore, we aimed to identify the predictors of mortality and healthcare costs associated with SE in one tertiary care center with limited resources.

Methods: This retrospective single-center cohort study, carried out at Namazi Hospital, Shiraz, Iran, included 130 SE cases from March 21, 2021, to March 20, 2022.

Comparison of Cardiac Magnetic Resonance Imaging Findings and Prognostic Measures in Nondilated Cardiomyopathy and Dilated Cardiomyopathy.

Nondilated left ventricular cardiomyopathy (NDLVC) is a newly defined category of cardiomyopathy. We sought to evaluate and compare the phenotype of NDLVC with DCM using cardiac magnetic resonance (CMR) imaging and to investigate the prognostic significance of these conditions. One hundred and fifty patients suspected of having cardiomyopathy referred for CMR were recruited.

Postoperative evaluation of interleukin-8 and C1q/TNF-related protein-12 in patients undergoing coronary artery bypass graft surgery.

Objective: Coronary artery bypass graft surgery is one of the most frequently performed surgeries worldwide. Coronary artery bypass graft surgery induces an inflammatory response. Interleukin-8 is a pro-inflammatory cytokine that plays a role in the pathogenesis of cardiovascular diseases.

COVID-19 pandemic effects on the emergency medical services utilization: A systematic review protocol.

To the best of our knowledge, to date, there is no comprehensive review study that has explored the effects and impacts of the COVID-19 pandemic on emergency medical services (EMS) systems. Therefore, this systematic review will be conducted to investigate the effects of the COVID-19 pandemic on the delivery of pre-hospital emergency care services in EMS agencies. To achieve the study aims, electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar will be searched for related studies.

Presence of the Anopheles culicifacies complex species A in southeast Iran.

Background: The Anopheles culicifacies complex is one of the most important malaria vectors in Southeast Asia and Southeastern Iran. Although the sibling species within this complex are morphologically indistinguishable, they differ significantly in their disease transmission potential, blood-feeding behaviour, and other biological traits. Cytogenetic and chromosomal studies have identified five sibling species within this complex: A, B, C, D, and E.

Low Bone Mineral Density and Associated Factors Among People Living With HIV in Kerman, Iran: A Cross-Sectional Study in 2021-2022.

Chronic diseases such as osteoporosis and low bone mineral density (BMD) are significant public health concerns for people living with HIV (PLWH), especially with the increased life expectancy because of antiretroviral therapy (ART). This study evaluated the prevalence and associated factors of low BMD among 94 PLWH in Kerman, Iran, from September 2021 to February 2022. Using dual-energy X-ray absorptiometry, BMD was measured, with low BMD defined by specific T-scores and Z-scores.

Protective effects of myrtenol against paraquat-induced toxicity in rats.

Background: Paraquat (PQ) is a widely used pesticide, can cause severe intoxication and respiratory failure. Myrtenol (Mrl), an essential oil derived in various plants, exhibits several biological properties, including anti-inflammatory and antioxidant activities. This study aims to investigate the protective potential of Mrl against oxidative stress and inflammation caused by PQ exposure.

N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis.

Background: Recent studies indicate that N6-methyladenosine (mA) RNA modification may regulate ferroptosis in cancer cells, while its molecular mechanisms require further investigation.

Methods: Liquid Chromatography-Tandem Mass Spectrometry (HPLC/MS/MS) was used to detect changes in mA levels in cells. Transmission electron microscopy and flow cytometry were used to detect mitochondrial reactive oxygen species (ROS).

Effect of acute kidney injury care bundle on kidney outcomes in cardiac patients receiving critical care: a systematic review and meta-analysis.

Background: Cardiac surgery is a major contributor to acute kidney injury (AKI); approximately 22% of patients who undergo cardiac surgery develop AKI, and among them, 2% will require renal replacement therapy (RRT). AKI is also associated with heightened risks of mortality and morbidity, longer intensive care stays, and increased treatment costs. Due to the challenges of treating AKI, prevention through the use of care bundles is suggested as an effective approach.

Facet joint tropism in degenerative lumbar scoliosis: a retrospective case-control study.

Background: To investigate the association between lumbar degenerative scoliosis and the dural sac cross-sectional area (DSCA), the lumbar canal anterior-posterior (LCAP) diameter, and the neural foraminal cross-sectional area (NFCA) in relation to facet joint tropism (FJT).

Methods: In a retrospective case-control study, we analyzed data from 160 patients referred for lumbar magnetic resonance imaging (MRI) between January 2020 and December 2022. Cobb's angle on anteroposterior lumbosacral X-ray is served to identify the presence of degenerative lumbar scoliosis-Cobb's angle exceeding 10 degrees-, and axial T2W MRI is implemented to evaluate facet joint angles and tropism-defined as a difference exceeding 10 degrees between the facet joint angles at each level-, DSCA, LCAP, and NFCA.

Brain mapping, biomarker identification and using machine learning method for diagnosis of anxiety during emotional face in preschool children.

Background: Due to the importance and the consequences of anxiety, the goals of the current study are brain mapping, biomarker identification and the use of an assessment method for diagnosis of anxiety during emotional face in preschool children.

Method: 45 preschool children participated in this study. Functional Magnetic Resonance Imaging (fMRI) data were taken in fearful and angry conditions.

Developing and evaluating a gamified self-management application for inflammatory bowel disease using the ADDIE model and Sukr framework.

Background: The prevalence and chronic nature of Inflammatory Bowel Diseases (IBD) is a significant global concern. As the essential part of treatments approach, patient adherence to treatment protocols and self-management practices are crucial to = IBD management. Healthcare initiatives focused on chronic conditions are strongly needed to consider various aspects of gamification and how it can positively affect self-management.

Therapeutic Potential of Agmatine in Essential Tremor Through Regulation of Lingo-1 and Inflammatory Pathways.

Purpose: Essential tremor (ET) is a prevalent movement disorder, yet current therapeutic options remain limited. Emerging evidence implicates leucine-rich repeat and immunoglobulin-like domain-containing protein (Lingo-1) and neuroinflammation in the pathophysiology of ET. This study aimed to investigate whether agmatine, a biogenic amine neuromodulator attenuates tremors and modulates the expression of Lingo-1 and proinflammatory markers in a rodent model of ET.

Identification and Characterization of Acanthamoeba from Contact Lens Care Solutions and Hospital Environments in the Ophthalmology Wards and Operating Rooms in Southeastern Iran.

Objective: Different Acanthamoeba species are among the most ubiquitous organisms causing serious diseases in humans including central nervous system (CNS) and eye infections. Contact lenses, lens care solutions and the hospital environments particularly the indoor and outdoor environments of ophthalmology wards where people are present with different types of eye diseases, are the potential sources of human infection. The purpose of the present study was the molecular investigation of free-living amoebae in the used contact lenses, lens care solutions and hospital samples from the ophthalmology wards and operating rooms in a referral hospital in southeastern Iran.

Resilience and social isolation in people living with HIV: a case study in Iran.

Objective: People living with HIV (PLHIV) often face increased vulnerability due to factors like social isolation and reduced resilience. These factors can negatively impact health outcomes, quality of life, and well-being for both PLHIV and their families. Therefore, healthcare providers should carefully assess these variables when providing care for PLHIV.

Academic burnout and its related factors among dental students in southeast Iran: a cross-sectional study.

Background And Aim: Academic burnout in students manifests as emotional exhaustion, depersonalization, and a sense of stagnation in their education. Given the high prevalence of occupational burnout among dental students, screening dental students for early signs of burnout can facilitate intervention and prevent negative effects on their physical and mental well-being.

Methods And Materials: This cross-sectional study included 180 clinical dentistry students in their third year and above at Kerman Dental Faculty during the academic year 2022-2023.

Facilitators and Barriers to adherence to antiretroviral therapy among incarcerated people living with HIV in Iran: insights from a qualitative study.

Background: Ensuring consistent adherence to antiretroviral therapy (ART) is crucial for effective HIV treatment and achieving viral suppression. Within prisons, the prevalence of HIV is notably high, and incarcerated individuals face an increased risk of transmitting the virus both during and after incarceration. However, facilitators and barriers to ART adherence among these individuals in low- and middle-income countries remain inadequately explored.