72 results match your criteria: "Kent State University College of Podiatric Medicine[Affiliation]"

Metabolic acidosis (MAc)-an extracellular pH (pH) decrease caused by a [HCO ] decrease at constant [CO]-usually causes intracellular pH (pH) to fall. Here we determine the extent to which the pH decrease depends on the pH decrease vs the concomitant [HCO ] decrease. We use rapid-mixing to generate out-of-equilibrium CO/HCO solutions in which we stabilize [CO] and [HCO ] while decreasing pH (pure acidosis, pAc), or stabilize [CO] and pH while decreasing [HCO ] (pure metabolic/down, pMet↓).

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Objective: This case series examines the use of a multimodal wound matrix (MWM) trialled in a selection of clinical practice settings and on a variety of hard-to-heal wounds. The objective was to evaluate the effects of MWM and its performance in managing such wounds, regardless of clinical setting and ulcer type.

Method: Treatment of the MWM was conducted by independent wound care practitioners on wounds that were of >4 weeks duration.

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Article Synopsis
  • The study aimed to test the effectiveness of a marine omega fatty acid-based wound matrix in reducing bacteria and promoting wound healing in tough-to-treat cases.
  • A pilot study involved three patients with non-healing wounds, showing promising results where two venous leg ulcers fully healed, and a diabetic foot ulcer showed over half its area reduced after six weeks.
  • The findings suggest that this marine-based wound matrix can be both effective and safe for patients who haven’t improved with standard treatments, highlighting its potential in wound care.
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Background: Sufficient oxygen is critical for multiple processes in wound healing. Nonhealing wounds have low tissue oxygen levels due to damaged microvasculature and comorbidities limiting tissue perfusion. Hypoxia may be reversed using continuous topical oxygen therapy (cTOT).

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A model for diabetic foot ulcer clinical trials on advanced therapies.

J Wound Care

March 2024

SerenaGroup Research Foundation, Cambridge, MA US.

TS is a consultant for Inotec AMD Ltd., UK. The authors have no other conflicts of interest to declare.

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Importance: Patients with kidney failure have an increased risk of diabetes-related foot complications. The benefit of regular foot and ankle care in this at-risk population is unknown.

Objective: To investigate foot and ankle care by podiatrists and the outcomes of diabetic foot ulcers (DFUs) in patients with kidney failure.

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Background: The long-term chronic effect of radiotherapy is commonly referred to as LRTI. Clinical complications such as skin atrophy, tissue fibrosis, endothelial damage, ulcer formation, and compromised wound healing are common sequela. Despite advances in medicine over the past decade, there remains a need for effective treatments for LRTI skin necrosis and ulcerations.

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  • Endoscopic calcaneoplasty (ECP) and gastrocnemius recession (GR) are surgical methods proposed to treat Haglund's deformity and mild to moderate insertional Achilles tendinopathy.
  • In a study of 14 patients with less than 50% tendinous degeneration, both procedures were performed, allowing weightbearing in a CAM boot within the first week post-surgery.
  • Results showed significant improvements in foot angles and AOFAS scores, indicating that ECP with GR is a safe and effective treatment option, although there were some cases of temporary nerve issues and delayed wound healing.
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  • The study examines the influence of rearfoot position (pronation/supination) and metatarsal torsion on the deformity hallux abducto valgus (HAV) in 12 subjects using weight-bearing CT.
  • Key findings reveal that while first metatarsal eversion is greater in a pronated foot, this difference is not statistically significant; however, there is a strong correlation between metatarsal torsion and eversion, particularly when the foot is pronated.
  • The research highlights the importance of multiple factors, including metatarsal torsion and pronation, in evaluating and treating HAV, suggesting that pre-operative weight-bearing CT scans can aid in surgical planning.
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Background: Amputations in the diabetic foot are commonly associated with complications, including delayed wound healing, surgical site dehiscence, and the need for additional amputations. Use of a novel adhesive suture retention device (ASRD) has been previously shown to support improved linear closure outcomes. The purpose of this retrospective case review was to determine if the adoption of the ASRD in 5 podiatric surgical practices would reduce postoperative complications in patients with diabetes undergoing foot amputations including surgical site dehiscence and the need for additional amputation.

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Use of Topical Oxygen Therapy in Wound Healing.

J Wound Care

August 2023

Clinic of Plastic, Hand and Aesthetic Surgery, Burn Center, BG Clinic Bergmannstrost, Halle (Saale, Germany); Medical University Halle, Outpatient and Operating Center, Martin-Luther University, Halle (Saale), Germany; University of Applied Science Anhalt, Institute of Applied Bioscience and Process Management, Head of Academic Wound Consultant Education Course, Koethen, Germany.

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Background: Elevated bacterial bioburden and biofilm formation are common causes for delayed wound healing. Biofilm is an assemblage of surface-associated microbes enclosed in a self-produced matrix. Identifying and managing biofilm is a crucial component of successful wound care protocols.

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Acute Low Dose Naltrexone Increases β-Endorphin and Promotes Neuronal Recovery Following Hypoxia-Ischemic Stroke in Type-2 Diabetic Mice.

Neurochem Res

September 2023

Department of Neural and Behavioral Sciences, Penn State University College of Medicine, 500 University Drive H109, Hershey, PA, 17033, USA.

Article Synopsis
  • Diabetic patients face high mortality rates and poor recovery from ischemic strokes, which is linked to immune suppression observed in studies of both humans and diabetic mice.
  • Low doses of naltrexone (LDN) have shown promise in improving health outcomes by enhancing immune responses through the release of β-endorphin, which helps balance inflammation.
  • In experiments with diabetic mice, LDN treatment post-stroke increased β-endorphin and opioid growth factor levels, reducing brain injury and promoting neuron recovery compared to untreated mice.
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Background: When evaluating hallux valgus (HV) deformity with anteroposterior (AP) foot radiographs, the distal metatarsal articular angle (DMAA) has been the subject of frequent debate. Although a straightforward indicator of structural alignment of the distal first metatarsal articular surface, inter- and intraobserver measurements can vary widely. Alterations in the radiographic appearance of bony "structure" with positional changes of the foot/foot bones in HV deformities in no small part contributes to these inaccuracies.

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Introduction: Plantar hallux wounds are common in patients with diabetic neuropathy. Several techniques, both surgical and nonsurgical, are designed to offload plantar wounds. However, controversy exists regarding which techniques are superior in terms of efficacy, safety, and longevity.

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Article Synopsis
  • Traditional hammertoe correction often uses end-to-end arthrodesis with temporary K-wire fixation, but this can lead to instability due to axial rotation and potential fusion failure.
  • Intramedullary implants offer better stability for the fusion site, although they can have positioning challenges and increase the risk of bony voids.
  • The study reviewed 100 patients treated with extramedullary implants, showing a 94% success rate in achieving bone union within about 8.8 weeks, suggesting this method effectively combines the benefits of previous techniques while reducing complications.
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Topical autologous blood clot therapy: consensus panel recommendations to guide use in the treatment of complex wound types.

Wounds

January 2023

Clinic of Plastic, Hand and Aesthetic Surgery, Burn Center, BG Clinic Bergmannstrost, Halle (Saale), Germany; Medical University Halle, Outpatient and Operating Center, Martin-Luther University, Halle (Saale), Germany; University of Applied Science Anhalt, Institute of Applied Bioscience and Process Management, Head of Education Course "Academic Wound Consultant" Koethen, Germany.

The etiology of acute and chronic wounds goes beyond those often reported in the literature, including those with exposed structures, those in which the entire wound bed cannot be visualized, and patients who are not candidates for typical standard of care. Treatment options for these patients may be limited. TABCT is a viable option for these complex wound types and is not hindered by logistical, procedural, or patient factors.

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Topical autologous blood clot therapy: an introduction and development of consensus panel to guide use in the treatment of complex wound types.

Wounds

September 2022

Clinic of Plastic, Hand and Aesthetic Surgery, Burn Center, BG Clinic Bergmannstrost, Halle (Saale), Germany; Medical University Halle, Outpatient and Operating Center, Martin-Luther University, Halle (Saale), Germany; University of Applied Science Anhalt, Institute of Applied Bioscience and Process Management, Head of Education Course "Academic Wound Consultant" Koethen, Germany.

Complex or hard-to-heal wounds can be acute or chronic; the complexity is based on patient-specific local, systemic, and psychosocial factors. Use of autologous tissue can be a significant adjunct to wound closure. Grafts and flaps are the most common autologous tissue used in wound reconstruction.

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A Proposed Algorithm to Diagnose and Treat Lower Extremity Hematomas.

Wound Manag Prev

July 2022

Certified Medical Writer, Scriptum Medica Medical Writing, University Place, Washington.

Background: Pretibial injury is common. Although the mechanism of injury may be minor, in a specific patient population, misdiagnosis and delay in appropriate treatment can lead to dire consequences. The ability to identify and properly treat these patients early has the potential to reduce the need for surgical intervention, hospitalization, and prolonged care.

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A growing body of evidence supports the use of topical oxygen therapy (TOT) in the treatment of diabetic foot ulcers (DFUs). In addition, anecdotal evidence suggests that topical oxygen may be effective in the treatment of other wound types. In May 2021, experts in the field of wound healing from across the US assembled in New Orleans for the inaugural Leaders in Wound Healing conference.

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PI3K/mTOR inhibition prevents anal cancer in mice with established low-grade anal dysplasia.

Exp Mol Pathol

April 2022

Department of Surgery, University of Wisconsin-Madison, USA 600 Highland Ave, Madison, WI 53792, USA; William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA; University of Wisconsin Carbone Cancer Center, UW Health University Hospital, 1111 Highland Ave, Madison, WI 53705, USA. Electronic address:

Low-grade anal dysplasia is a disease that can progress to high-grade anal dysplasia and eventually anal cancer if left untreated. Research has shown that low-grade anal dysplasia is marked by significant autophagic dysfunction. We hypothesized that systemic induction of autophagy, via phosphoinositide 3-kinase/mammalian target of rapamycin (PI3K/mTOR) inhibition, would be effective in preventing anal cancer development in human papillomavirus (HPV) mice (K14E6/E7) with established low-grade anal dysplasia.

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Nonuremic calciphylaxis is a rare condition presenting with peripheral ischemic ulcerations. Calciphylaxis is the deposition of calcium and phosphate into arteriolar walls caused by exceeding their solubility range in the blood. It is most commonly seen in patients with end-stage renal disease; however, nonuremic calciphylaxis occurs in patients with normal or mildly impaired renal function.

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Metaplasia is a well documented and deleterious effect of crude oil components on oysters. This reversible transformation of one cell type to another is a common response to petroleum-product exposure in molluscs. It has been shown experimentally in previous work that eastern oysters (Crassostrea virginica) exposed to petroleum products will exhibit metaplasia of digestive tissues.

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Article Synopsis
  • Bone grafting from the calcaneus (heel bone) is effective in foot and ankle surgery due to its easy access and good blood supply.
  • This study used fresh-frozen cadaver limbs to analyze the volume of cancellous bone that can be harvested while identifying safe anatomical zones and risks to nearby nerves and blood vessels.
  • Findings showed that an average of 0.85 cc of bone could be obtained with a small incision, and no damage to nerves was detected, suggesting this method could enhance surgical outcomes.
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Imaging of the Pes Cavus Deformity.

Clin Podiatr Med Surg

July 2021

Adjunct Faculty, St. Vincent Charity Medical Center, Cleveland, OH, USA.

Article Synopsis
  • Direct-type cavus foot deformities are common and primarily involve changes in the sagittal plane, which affects the foot's alignment.
  • It's important to distinguish these from the less common triplane pes cavovarus deformities.
  • The lateral weight-bearing radiograph is essential for evaluating these deformities, and specific angles on the radiograph help classify their severity and inform surgical decisions.
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