1 results match your criteria: "Kennedy Krieger Institute's F.M. Kirby Research Center[Affiliation]"
Split Tolerance in a Murine Model of Heterotopic En Bloc Chest Wall Transplantation.
Plast Reconstr Surg Glob Open
December 2017
Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.; Ruprecht-Karls University Heidelberg Medical Faculty, Heidelberg, Germany; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Md.; and Radiology and Radiological Science-Magnetic Resonance Research, Institute for Cell Engineering, Kennedy Krieger Institute's F.M. Kirby Research Center, Baltimore, Md.
Background: Congenital and acquired chest wall deformities represent a significant challenge to functional reconstruction and may impact feasibility of heart transplantation for patients with end-stage organ failure. In the recent past, the concept of replacing like-with-like tissue by using vascularized composite allografts (VCA) has been enthusiastically employed for reconstruction of complex tissue defects.
Methods: In this study, we introduce a novel murine model for en bloc chest wall, heart, and thymus transplantation and thereby the use of complex tissue allografts for reconstruction of both chest wall defects and also end-stage organ failure.