1,596 results match your criteria: "Keloid and Hypertrophic Scar"
[Effects of low dose skin tissue derived peptides on the function and collagen expression of keloid fibroblasts].
Zhonghua Yu Fang Yi Xue Za Zhi
September 2024
Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Article Synopsis
- - This study examines how peptides from skin tissue influence the growth, death, movement, and collagen levels in keloid fibroblasts, focusing on patients with hypertrophic scars who had surgery between 2015 and 2017.
- - Four specific peptides were selected for analysis, and various tests (like CCK-8 for cell viability, flow cytometry for apoptosis, and Transwell chamber for migration) were conducted to assess their effects.
- - Results indicated that while the peptides didn't significantly impact cell survival or apoptosis, one peptide (PDHPS5) notably reduced cell migration, and all four peptides significantly lowered collagen type I alpha 2 protein levels compared to controls.
Reflectance Confocal Microscopy and Dermoscopy for the Diagnosis of Solitary Hypopigmented Pink Lesions: A Narrative Review.
Cancers (Basel)
August 2024
IDI-IRCCS, Dermatological Research Hospital, 00167 Rome, Italy.
Article Synopsis
- Diagnosing solitary pink skin lesions is challenging due to the overlap of clinical features among both benign (like cherry angiomas) and malignant lesions (such as basal cell carcinoma).
- Reflectance confocal microscopy (RCM) improves diagnostic accuracy beyond traditional dermoscopy, offering better sensitivity and specificity for identifying these lesions.
- Despite advancements, a definitive diagnosis still requires surgical excision and histopathological analysis to ensure correct treatment.
A Comparative Analysis of the Advances in Scar Reduction: Techniques, Technologies, and Efficacy in Plastic Surgery.
Cureus
August 2024
Orthopedic Surgery, Holy Cross Hospital, Fort Lauderdale, USA.
Article Synopsis
- This study analyzes current methods and treatments for improving scar management, focusing on how scars differ from healthy skin due to the formation of fibroblasts and structured collagen bundles.
- It classifies scars into hypertrophic and keloids, emphasizing the need for standardized assessment tools like the Vancouver Scar Scale for effective scar evaluation.
- The review covers a range of scar management techniques, from traditional methods to advanced therapies like microneedling and platelet-rich plasma, and highlights the potential of botulinum toxin A in scar treatment while calling for more research to optimize these approaches.
Suction-Based Optical Coherence Elastography for the Biomechanical Characterization of Pathological Skin Conditions: A Pilot Study.
J Biophotonics
November 2024
Amsterdam UMC, Location VUmc, Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Article Synopsis
- Accurate characterization of mechanical properties is essential for assessing therapeutic effects on problematic skin conditions, particularly keloids and hypertrophic scars.
- A pilot study utilized a new optical coherence elastography (OCE) device that combines imaging techniques with suction-based deformation to assess skin mechanics, validated against a commercial instrument and subjective assessments.
- Results indicated significant differences in mechanical and structural properties in pathological skin compared to healthy tissue, demonstrating the potential clinical application of this novel OCE device for evaluating scars.
Article Synopsis
- A study investigated the effectiveness of siRNA-embedded microneedle patches in reducing excessive scar tissue compared to conventional silicone sheets in post-surgical scars.
- The trial involved a random allocation of two-week-old surgical wounds to receive either treatment, and scar volume was measured at 30 and 60 days using high-resolution scanning.
- Results showed that scars treated with microneedle patches had significantly smaller volumes and higher percentage reductions in scar formation compared to those treated with silicone sheets, indicating a potential new approach to scar management.
Effective Treatment of an Aggressive Chest Wall Keloid in a Woman Using Deprodone Propionate Plaster without Surgery, Radiotherapy, or Injection.
Plast Reconstr Surg Glob Open
September 2024
From the Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.
Article Synopsis
- In Japan, steroid tape is the primary treatment for keloid and hypertrophic scars, which is highlighted in a case study of a woman with an aggressive keloid on her chest that had persisted and worsened for 40 years.* -
- Initially, a multidisciplinary approach involving surgery and radiation was considered necessary, but the keloid was successfully treated using only steroid tape (deprodone propionate plaster).* -
- This successful treatment case supports the effectiveness of steroid tape and suggests that more reports are needed to increase awareness and use of this option among plastic surgeons and dermatologists globally.*
Phosphodiesterase 4 is overexpressed in keloid epidermal scars and its inhibition reduces keratinocyte fibrotic alterations.
Mol Med
September 2024
CIBER de enfermedades respiratorias, Health Institute Carlos III, Valencia, Spain.
Article Synopsis
- * Researchers conducted in vitro experiments on human 3D epidermis and in vivo studies on mice to assess how PDE4 inhibitors affect TGFβ1-induced epithelial transformations and skin fibrosis.
- * Results indicate elevated PDE4B levels in keloids and HTS and confirm that inhibiting PDE4 prevents TGFβ1-induced changes that lead to fibrosis, suggesting PDE4 inhibitors could be a promising treatment for these skin conditions.
Safety and efficacy of intralesional bleomycin for keloids and hypertrophic scars: A systematic review and meta-analysis.
J Cosmet Dermatol
November 2024
Plastic and Reconstructive Surgery & Burns, Affiliated Hospital of North Sichuan Medical College, Sichuan, Nanchong, China.
Article Synopsis
- Bleomycin, initially an antitumor drug, was researched for treating hypertrophic scars and keloids, with mixed results regarding efficacy and safety among individuals.
- A review of various studies revealed that topical bleomycin was more effective in scar reduction compared to triamcinolone, but showed no significant differences in pigmentation and recurrence rates versus other treatments.
- While bleomycin led to less skin atrophy and telangiectasia, it was associated with increased pain; further studies are needed for a thorough evaluation of its safety and effectiveness.
Experimental Study of Ultra-Pulsed CO 2 Fractional Laser Combined With Recombinant Human Epidermal Growth Factor Gel in the Treatment of Eyelid Keloid.
Ophthalmic Plast Reconstr Surg
August 2024
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University.
Article Synopsis
- The review investigates the effectiveness of using ultra-pulsed CO2 fractional laser therapy combined with recombinant human epidermal growth factor (rHEGF) gel in treating keloids on the eyelids.
- A total of 98 patients who underwent surgery were divided into two groups, one receiving the combination treatment and the other only laser therapy; after dropouts, 47 and 46 cases were analyzed.
- Results showed that while no significant differences were detected in baseline characteristics between groups, the combination treatment significantly improved scar assessment scores compared to laser therapy alone.
Central centrifugal cicatricial alopecia is associated with keloid scarring in Black women: A retrospective chart review.
J Am Acad Dermatol
December 2024
Division of Dermatology, Albert Einstein College of Medicine, Bronx, New York.
Inviscision: A Futuristic Alternative to Endaural Incision for TMJ Surgeries.
J Maxillofac Oral Surg
August 2024
Department of Oral & Maxillofacial Surgery, Government Dental College & Hospital, Ahmedabad, Gujarat India.
Article Synopsis
- The study examines two surgical techniques for TMJ surgery: the traditional endaural incision and the newer Inviscision, focusing on surgical exposure, nerve injury, and aesthetic results.
- The results showed that Inviscision requires slightly more time but leaves an invisible scar, while endaural leaves a thin visible line; both techniques had similar rates of nerve weakness with no severe complications.
- Overall, Inviscision is favored for its cosmetic benefits despite slightly longer surgical time, while endaural incision may be more efficient in terms of exposure time.
Evidence of a causal relationship between blood pressure and pathological scars: a bidirectional Mendelian randomization study.
Front Med (Lausanne)
July 2024
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Background: Recent advancements in basic medicine and epidemiology suggest a potential influence of blood pressure on scar formation, yet the specifics of this relationship are not fully understood. This study aims to clarify the causal link between blood pressure and the development of pathological scars using Mendelian randomization (MR).
Methods: This study employed genetic variants closely linked to blood pressure as instrumental variables to explore the relationship between blood pressure and pathological scars.
Hypertrophic scarring and scar revision in gender-affirming mastectomy: a systematic review.
Arch Dermatol Res
August 2024
Department of Plastic Surgery, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN, USA.
Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-β and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model.
Tissue Eng Regen Med
October 2024
Department of Plastic and Reconstructive Surgery, Yonsei University, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, Korea.
Article Synopsis
- Keloids and hypertrophic scars are caused by abnormal collagen buildup, linked to the TGF-β/SMAD signaling pathway, and the study explores the potential of a ZAG-derived peptide to treat these conditions.
- In laboratory tests, the ZAG peptide reduced collagen types I and III in skin cells, while increasing levels of certain proteins that help break down the extracellular matrix, indicating its effectiveness against scar formation.
- Animal studies showed that the ZAG peptide led to narrower scars and less immature collagen, suggesting it could be a promising treatment option for keloids and hypertrophic scars by targeting specific cellular pathways.
Development of huge keloid at donor site and recurrent keloid at graft site after excision of pubic keloid followed by split-thickness skin graft: A case report.
Medicine (Baltimore)
August 2024
Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Article Synopsis
- Keloids are abnormal tissue scars that can cause pain and psychological issues, often requiring surgical excision despite high chances of reoccurrence.
- A 32-year-old woman with a large keloid on her pubic area experienced significant symptoms and also had multiple other keloids, indicating a predisposition to develop them.
- After surgery and a skin graft, the patient opted out of follow-up care due to financial constraints, which led to the resurgence of keloids at both the graft and donor sites after some time.
Alexis® Orthopedic Protector Provides Wound Protection and Aids in Hypertrophic Scar Prevention in Total Hip Arthroplasty.
Cureus
June 2024
Department of Bone and Joint Surgery, Kawasaki Medical School, Okayama, JPN.
Article Synopsis
- Total hip arthroplasty (THA) is a common surgery, but it can lead to skin and muscle complications; this study investigates the impact of using Alexis Orthopedic Protectors during surgery.
- In a study with 118 patients, those who had the protector (P group) showed significantly less postoperative redness and fewer hypertrophic scars compared to those who did not (N group).
- The results suggest that Alexis Orthopedic Protectors improve wound outcomes after THA, leading to better short-term healing and reduced scarring.
Liposomes Loaded with 5-Fluorouracil Can Improve the Efficacy in Pathological Scars.
Int J Nanomedicine
July 2024
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
Article Synopsis
- - Pathological scars, like hypertrophic scars and keloids, are caused by excessive fibroblast activity and collagen buildup, leading to pain, itching, and psychological distress for patients.
- - Researchers developed 5-fluorouracil (5-Fu) loaded liposomes (5-Fu-Lip) to enhance the delivery and effectiveness of 5-Fu for treating these scars, overcoming issues of limited drug penetration.
- - 5-Fu-Lip demonstrated better results in reducing fibroblast activity and scar severity compared to traditional 5-Fu, suggesting it could be a more effective treatment option for pathological scars.
Causal relationship between gut microbiota and pathological scars: a two-sample Mendelian randomization study.
Front Med (Lausanne)
July 2024
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- Pathological scars, like keloids and hypertrophic scars, are challenging skin conditions, with emerging research suggesting that the gut microbiota may play a significant role in their development.
- This study used a two-sample Mendelian randomization approach to analyze data from genome-wide association studies to investigate the relationship between gut bacteria and these types of scars.
- Findings indicate that specific bacterial taxa are causally linked to the formation of both keloids and hypertrophic scars, highlighting the potential of gut microbiota as a target for further research on scar treatment.
Efficacy and Safety of Corticosteroid in Combination with 5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis.
Aesthetic Plast Surg
October 2024
School of Physics and Technology, Nantong University, NanTong, Jiangsu, China.
Article Synopsis
- Addressing hypertrophic scars and keloids is challenging, and this study aims to evaluate the effectiveness and safety of combining corticosteroids with 5-fluorouracil (5-FU) for treatment.
- A systematic search identified 15 studies, showing that the combined treatment group had significantly better outcomes in terms of scar height and patient assessments compared to the control group, despite no major differences in scar vascularity, pliability, and pigmentation.
- The results indicate that the corticosteroid and 5-FU combination is a more effective treatment option with fewer side effects, providing a promising strategy for managing these types of scars.
Stomal Stenosis After Continent Urinary Diversion in Bladder Exstrophy: Risk Factors and Management.
Urology
September 2024
James Buchanan Brady Urological Institute, Division of Pediatric Urology, Douglas A. Canning MD Exstrophy Database Center, Charlotte Bloomberg Children's Hospital, The Johns Hopkins Medical Institutions, Baltimore, MD. Electronic address:
Objective: To identify risk factors for stenosis and compare management strategies for stenosis etiology and to examine the efficacy of each approach. Patients with classic bladder exstrophy (CBE), a rare genitourinary malformation, may require construction of a continent urinary stoma (CUS) if incontinence persists. Stomal stenosis is a challenging complication as it is common, progressive, and recurrent.
View Article and Find Full Text PDFThe potential of RNA therapeutics in dermatology.
Ann Acad Med Singap
February 2024
National Skin Centre, Singapore.
Ribonucleic acid (RNA) therapeutics hold great potential for the advancement of dermatological treatments due to, among other reasons, the possibility of treating previously undruggable targets, high specificity with minimal side effects, and ability to include multiple RNA targets in a single product. Although there have been research relating to RNA therapeutics for decades, there have not been many products translated for clinical use until recently. This may be because of challenges to the application of RNA therapeutics, including the dearth of effective modes of delivery to the target, and rapid degradation of RNA in the human body and environment.
View Article and Find Full Text PDFA Comprehensive Review of Non-Surgical Treatments for Hypertrophic and Keloid Scars in Skin of Color.
Clin Cosmet Investig Dermatol
June 2024
Department of Research, Scar Healing Institute, Los Angeles, CA, USA.
Hypertrophic and keloid scars are fibroproliferative growths resulting from aberrant wound healing. Individuals with Fitzpatrick skin types (FSTs) IV-VI are particularly predisposed to hypertrophic and keloid scarring, yet specific guidelines for these populations are still lacking within the literature. Therefore, this comprehensive review provides a list of various treatments and considerations for hypertrophic and keloid scarring in patients with skin of color.
View Article and Find Full Text PDFInvestigating the impact of botulinum toxin type a on the migration of normal human dermal fibroblasts: An in vitro wound healing assay.
J Cosmet Dermatol
October 2024
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Background: Botulinum toxin A (BoNT-A) is widely utilized in the management of hypertrophic and keloid scars. One proposed mechanism for scar prevention involves the inhibition of fibroblast migration in scars by BoNT-A. However, the data regarding the effect of BoNT-A on the migration of normal human dermal fibroblasts (NHDF) is limited.
View Article and Find Full Text PDFSHH induces macrophage oxidative phosphorylation and efferocytosis to promote scar formation.
Cell Commun Signal
June 2024
Department of Plastic and Reconstructive Surgery, The First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Street, Beijing, 100853, China.
Excessive scar formation such as hypertrophic scars and keloids, resulting from trauma or surgical procedures, present a widespread concern for causing disfigurement, discomfort, and functional limitations. Macrophages play pivotal roles in maintaining tissue homeostasis, orchestrating tissue development, repair, and immune responses, and its transition of function and phenotype plays a critical role in regulating the balance between inflammation and tissue regeneration, which is central to cutaneous scar formation. Recent evidence suggests the involvement of Sonic Hedgehog (SHH) in the induction of anti-inflammatory M2-like macrophage phenotypes within tumor microenvironments.
View Article and Find Full Text PDFEnhanced bioenergetic cellular activity with metabolic switch to aerobic glycolysis in Keloid and Folliculitis Keloidalis Nuchae.
Arch Dermatol Res
June 2024
MRC-SA Wound Healing and Keloid Research Unit, Division of Dermatology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Keloid scars and folliculitis keloidalis nuchae (FKN) are benign fibroproliferative dermal lesions of unknown aetiology and ill-defined treatment, which typically present in genetically susceptible individuals. Their pathognomonic hallmarks include local aggressive invasive behaviour plus high recurrence post-therapy. In view of this, we investigated proliferative and key parameters of bioenergetic cellular characteristics of site-specific keloid-derived fibroblasts (intra(centre)- and peri(margin)-lesional) and FKN compared to normal skin and normal flat non-hypertrophic scar fibroblasts as negative controls.
View Article and Find Full Text PDF