258 results match your criteria: "Keiyu Hospital.[Affiliation]"

Article Synopsis
  • Schnitzler syndrome is an adult-onset autoinflammatory condition presenting with a rash, fever, and fatigue, but lacks an approved treatment, prompting this study on canakinumab.
  • In this phase II trial, five patients received a single dose of canakinumab, with the goal of achieving a complete clinical response (CR) and tracking improvements in quality of life and inflammatory markers.
  • The results indicated that 60% of patients achieved CR by Day 7, and all patients demonstrated improvements in inflammation and quality of life, suggesting canakinumab may be beneficial for those with Schnitzler syndrome.
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Clinical relevance of proteinuria selectivity index and fractional excretion of sodium in patients with nephrotic syndrome.

Sci Rep

October 2024

Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.

Article Synopsis
  • The study investigates the potential of the Proteinuria Selectivity Index (PSI) and fractional excretion of sodium (FENa) as tools for classifying nephrotic syndrome and predicting treatment responses.
  • It involved a retrospective analysis of 611 patients who underwent kidney biopsies, categorizing their conditions and determining optimal cutoffs for PSI and FENa to predict complete remission.
  • The findings indicate that both low PSI and FENa are associated with a higher likelihood of achieving complete remission, suggesting their clinical relevance in nephrotic syndrome management.
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Article Synopsis
  • - This study focused on 111 patients with advanced gastric cancer who were treated with nivolumab to monitor their disease progression and evaluate treatment response using serum inflammatory markers like CRP-to-albumin ratio (CAR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR).
  • - Results indicated an overall response rate of 11.7% and a disease control rate of 44.1%, with median overall survival of 14 months and progression-free survival of 4.1 months.
  • - Changes in the inflammatory markers after therapy proved to be useful in predicting treatment response, with specific cutoff values identified for CAR, PLR, and NLR that correlated
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Article Synopsis
  • A retrospective multicenter study was conducted in Japan to assess the influence of preoperative neck pain on clinical outcomes after posterior decompression surgery for cervical ossification of the posterior longitudinal ligament (OPLL).
  • The study involved 90 patients followed for at least two years, who were grouped based on the presence or absence of preoperative neck pain, but the two groups showed no significant demographic or outcome differences.
  • Both groups improved post-surgery according to the Japanese orthopedic association (JOA) scores, but lower JOA scores and larger cervical angles in the no preoperative pain group were linked to higher chances of developing postoperative neck pain.
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Article Synopsis
  • * Drugs were categorized based on name similarity (Name-Similar vs. Name-Dissimilar) and efficacy similarity (Efficacy-Same, Efficacy-Close, Efficacy-Far), revealing a notably higher error rate (36%) for pairs with similar names and the same efficacy.
  • * Findings suggest that drug name similarity significantly increases the risk of dispensing errors, indicating the m2-vwhtfrag index is a valuable tool for assessing these errors and helping to predict risks associated with new medications.
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Background: The annual administration of the influenza vaccine is the most effective method for preventing influenza. We have evaluated the effectiveness of the inactivated influenza vaccine in children aged 6 months to 15 years across the seasons from 2013/2014 to 2022/2023. This study aims to investigate the effectiveness of the inactivated influenza vaccine in the 2023/2024 season, the first year following the easing of strict COVID-19 measures, and possibly the last season when only the inactivated vaccine is available on the market.

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Purpose: The concept of non-mass abnormalities of the breast has been employed in Japan for approximately 20 years. Although B-mode findings are classified as non-mass abnormalities, the usefulness of adding color Doppler ultrasonography (US) and strain elastography to B-mode US is unclear. Therefore, we conducted a multicenter study (JABTS BC-07) to establish the diagnostic criteria for breast US, including color Doppler and elastography, for non-mass abnormalities of the breast and verify their diagnostic usefulness.

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Article Synopsis
  • Childhood interstitial lung diseases (chILDs) are serious respiratory disorders with high mortality and significant health issues in children.
  • Adult interstitial lung disease classifications do not apply to chILDs, leading to new classifications specifically for children under 2 and those aged 2 to 18.
  • The review highlights the different imaging characteristics of chILDs, noting that infantile ILDs have distinct features, whereas pediatric ILDs can resemble adult forms.
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Purpose: This study aimed to determine whether the administration of a modified thoracoabdominal nerves block through perichondrial approach (M-TAPA) could result in the blockade of the lateral cutaneous branches. This study focused on a newly discovered anatomical space/plane adjacent to the M-TAPA plane, which we termed "space between the endothoracic fascia, diaphragm, and costodiaphragmatic recess: SEDIC."

Methods: Thirteen sides of nine formalin-embalmed cadavers were macroscopically dissected to investigate the anatomical spaces related to the effects of M-TAPA.

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Article Synopsis
  • This study analyzed the surgical outcomes of posterior decompression for cervical ossification of the posterior longitudinal ligament (OPLL), comparing procedures performed by board-certified spine (BCS) surgeons and non-board-certified (NBCS) surgeons.
  • It included 203 patients monitored for at least one year, measuring their clinical outcomes pre-surgery and after, focusing on factors like surgery duration, blood loss, and post-operative recovery.
  • Results showed no significant differences in surgical metrics or recovery outcomes between BCS and NBCS groups, indicating that surgery performed by well-trained junior surgeons under supervision is safe and effective.
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Mineralocorticoid receptor overactivation in diabetes mellitus: role of O-GlcNAc modification.

Hypertens Res

August 2024

Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Oita, Japan.

Hypertension is a significant risk factor for microangiopathy and cardiovascular complications in diabetic patients. The efficacy of mineralocorticoid receptor (MR) antagonists in impeding the advancement of diabetic nephropathy, along with the reduction in active renin concentration observed in diabetic retinopathy, strongly implies the involvement of MR overactivation in diabetic complications. This review provides a comprehensive review of various mechanisms proposed for MR overactivation in diabetes mellitus.

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Study Design: A retrospective study at a single academic institution.

Purpose: This study aimed to identify imaging risk factors for stenosis in extended neck positions undetectable in preoperative neutral magnetic resonance imaging (MRI) and improving decompression strategies for cervical spine disorders.

Overview Of Literature: Cervical disorders are influenced by various dynamic factors, with spinal stenosis appearing during neck extension.

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Background: In patients with traumatic posterior shoulder instability, little is known about the precise location and size of the reverse Hill-Sachs lesion.

Methods: Forty-nine shoulders of 47 patients with traumatic posterior instability were included in this study based on the following inclusion criteria: (1) a primary or recurrent traumatic posterior shoulder dislocation and (2) the initial event being caused by trauma. Patients were excluded if they had (1) no history of trauma, (2) prior shoulder surgery, (3) no computed tomographic (CT) examination, or (4) were seizure cases.

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Background: To evaluate visual performance after implantation of the TFNT (Acrysof Panoptix, Alcon, Fort Worth, Texas, USA) and CNWT (Clareon Panoptix, Alcon, Fort Worth, Texas, USA) intraocular lens (IOL), and compare the lens shape observed by scanning electron microscope (SEM).

Methods: Eighteen patients (18 eyes) received implantation of the CNWT and Twenty patients (20 eyes) received implantation of the TFNT. Exclusion criteria were previous ocular surgeries, ocular pathologies, or corneal abnormalities.

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Article Synopsis
  • - The study investigates long COVID symptoms among 935 patients in Japan, categorizing them into five distinct clusters based on various symptom presentations and their impact on quality of life (QOL).
  • - The clusters include: numerous symptoms affecting multiple organs, minimal symptoms, taste and smell disorders, fatigue with psychological symptoms, and fatigue with respiratory issues, showcasing a diverse range of long COVID experiences.
  • - Findings highlight the need for personalized treatment approaches, as the severely affected patients (mostly elderly in cluster 1) experienced the greatest decline in QOL, while other clusters showed different symptom trends and demographic profiles.
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Response to Letter to the Editor.

Am J Geriatr Psychiatry

April 2024

Healthy Aging Innovation Center (MK), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan; Department of Biostatistics, School of Medicine (MK), Yokohama City University, Yokohama, Japan; Department of Anesthesiology (MK), Keiyu Hospital, Yokohama, Japan; Department of Health Data Science, Graduate School of Data Science (TM), Yokohama City University, Yokohama, Japan; Department of Anesthesiology, School of Medicine (TM), Yokohama City University, Yokohama, Japan; Department of Health Data Science (MT), Tokyo Medical University, Tokyo, Japan; Department of Anesthesiology (MO), Saitama Cancer Center, Saitama, Japan.

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A case study of pyloric stenosis caused by metastatic lobular carcinoma of breast.

J Surg Case Rep

December 2023

Department of Surgery, Keiyu Hospital, 3-7-3 Minatomirai, Nishi-ku, Yokohama, Kanagawa 220-8521, Japan.

Metastasis to the gastrointestinal tract is rare. A 59-year-old woman who had a history of an invasive lobular carcinoma of breast with clinical complete response visited our hospital and complained of an upper abdominal pain and distension. We performed an upper gastrointestinal endoscopy which showed only a gastric ulcer without any malignant findings.

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Background: The risk and prognosis of pancreatobiliary cancer and in patients with autoimmune pancreatitis (AIP) and IgG4-related sclerosing cholangitis (IgG4-SC) remain unclear. Therefore, we retrospectively investigated the risk of pancreatobiliary cancer and prognosis in patients with AIP and IgG4-SC.

Methods: Patients with AIP and IgG4-SC at seven centers between 1998 and 2022 were investigated.

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Article Synopsis
  • The study investigated if brain imaging could predict cochlear implant (CI) outcomes for patients with severe to profound hearing loss before surgery.
  • A total of 64 patients, including those with congenital and acquired hearing loss, underwent preoperative MRI analysis to assess cortical thickness in specific brain regions.
  • Results indicated that certain brain areas, especially in the right and left hemispheres, correlated with better speech discrimination, particularly in patients with acquired hearing loss, suggesting that brain structure could guide clinical decisions for CI.
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With the rising numbers of patients infected with severe acute respiratory syndrome coronavirus 2, long coronavirus disease 2019 (COVID-19)-a sequelae of COVID-19-has become a major problem. Different sexes and age groups develop different long COVID symptoms, and the risk factors for long COVID remain unclear. Therefore, we performed subgroup analyses of patients with COVID-19, classifying them into different groups.

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The 2022 revision of the Japanese Breast Cancer Society (JBCS) Clinical Practice Guidelines for surgical treatment of breast cancer was updated following a systematic review of the literature using the Medical Information Network Distribution Service (MINDS) procedure, which focuses on the balance of benefits and harms for various clinical questions (CQs). Experts in surgery designated by the JBCS addressed five areas: breast surgery, axillary surgery, breast reconstruction, surgical treatment for recurrent and metastatic breast cancer, and other related topics. The revision of the guidelines encompassed 4 CQs, 7 background questions (BQs), and 14 future research questions (FRQs).

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Dermatomyositis (DM) is an idiopathic inflammatory myopathy. The incidence of malignancy in DM patients is quite high. Anti-transcription intermediary factor 1-γ (anti-TIF1-γ) antibody is more prevalent in DM patients with malignancy than in those without malignancy.

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