20 results match your criteria: "Keio University Tsuruoka[Affiliation]"

Territorial aggression is widespread across the animal kingdom and is expressed in diverse ecological and social contexts. In addition, there are marked variations in the degree of male reproductive territoriality within and between species. These differences are often attributed to genetic components.

View Article and Find Full Text PDF

The Bonin Islands, comprised of the Mukojima, Chichijima, and Hahajima Islands, are known for their isolated and distinctive habitats, hosting a diverse array of endemic flora and fauna. In these islands, adaptive radiation has played a remarkable role in speciation, particularly evident in the genus that is represented by three species: and exclusive to the Chichijima Islands, and , distributed across the entire Bonin Islands. Notably, exhibits multiple ecotypes, differing in leaf hair density, flowering time, and tree size.

View Article and Find Full Text PDF

Unlabelled: Resistance to immune checkpoint blockade remains challenging in patients with non-small cell lung cancer (NSCLC). Tumor-infiltrating leukocyte (TIL) quantity, composition, and activation status profoundly influence responsiveness to cancer immunotherapy. This study examined the immune landscape in the NSCLC tumor microenvironment by analyzing TIL profiles of 281 fresh resected NSCLC tissues.

View Article and Find Full Text PDF

Countershading, characterized by a darker dorsal surface and lighter ventral surface, is common among many animals. This dorsoventral pigment polarity is often thought to be adaptive coloration for camouflage. By contrast, noncountershaded (melanistic) morphs often occur within a species due to genetic color polymorphism in terrestrial animals.

View Article and Find Full Text PDF

Context: Genetic diversity is one of the most important facets of biological diversity, and changes in the spatial pattern of habitats, often modified by human activity, are believed to have affected the genetic diversity of resident natural populations.

Objectives: We undertook a landscape genetic analysis in order to determine which landscape features influence gene flow within Asian black bear populations and to identify the underlying processes.

Methods: In our evaluation of gene flow, we estimated four parameters of resistance with regard to landscape elevation: the mean, the difference between the highest and lowest, the standard deviation, and the coefficient of variation of elevation among individuals.

View Article and Find Full Text PDF

Background: Metabolome analysis is one of the omics which investigates the final product of a central dogma. Changes of liver metabolites during liver regeneration following hepatectomy (Hx) continue to remain unclear. The aim of the present study was to investigate the changes of liver metabolites following Hx with ischemia reperfusion (I/R) towards liver regeneration.

View Article and Find Full Text PDF

Can the second law of thermodynamics hold in cell cultures?

Front Genet

August 2015

Institute for Advanced Biosciences, Keio University Tsuruoka, Japan ; Systems Biology Program, Graduate School of Media and Governance, Keio University Fujisawa, Japan.

View Article and Find Full Text PDF

Quantifying periodicity in omics data.

Front Cell Dev Biol

November 2014

Institute for Advanced Biosciences, Keio University Tsuruoka, Japan.

Oscillations play a significant role in biological systems, with many examples in the fast, ultradian, circadian, circalunar, and yearly time domains. However, determining periodicity in such data can be problematic. There are a number of computational methods to identify the periodic components in large datasets, such as signal-to-noise based Fourier decomposition, Fisher's g-test and autocorrelation.

View Article and Find Full Text PDF

Welcome to the new tRNA world!

Front Genet

October 2014

Functional RNA Group, Institute for Advanced Biosciences, Keio University Tsuruoka, Japan.

View Article and Find Full Text PDF

Advances in systems immunology and cancer.

Front Physiol

July 2014

Systems Immunology, Institute for Advanced Biosciences, Keio University Tsuruoka, Japan ; Systems Biology Program, Graduate School of Media and Governance, Keio University Fujisawa, Japan.

View Article and Find Full Text PDF

tRNA gene diversity in the three domains of life.

Front Genet

June 2014

Institute for Advanced Biosciences, Keio University Tsuruoka, Japan.

Transfer RNA (tRNA) is widely known for its key role in decoding mRNA into protein. Despite their necessity and relatively short nucleotide sequences, a large diversity of gene structures and RNA secondary structures of pre-tRNAs and mature tRNAs have recently been discovered in the three domains of life. Growing evidences of disrupted tRNA genes in the genomes of Archaea reveals unique gene structures such as, intron-containing tRNA, split tRNA, and permuted tRNA.

View Article and Find Full Text PDF

Non-genetic adaptive dynamics for cellular robustness.

Front Genet

December 2013

Institute for Advanced Biosciences, Keio University Tsuruoka, Japan ; Systems Biology Program, Graduate School of Media and Governance, Keio University Fujisawa, Japan.

View Article and Find Full Text PDF

Uncertainty and certainty in cellular dynamics.

Front Genet

May 2013

Institute for Advanced Biosciences, Keio University Tsuruoka, Japan ; Graduate School of Media and Governance, Keio University Fujisawa, Japan.

View Article and Find Full Text PDF

Is central dogma a global property of cellular information flow?

Front Physiol

November 2012

Institute for Advanced Biosciences, Keio University Tsuruoka, Yamagata, Japan ; Graduate School of Media and Governance, Keio University Fujisawa, Kanagawa, Japan.

The central dogma of molecular biology has come under scrutiny in recent years. Here, we reviewed high-throughput mRNA and protein expression data of Escherichia coli, Saccharomyces cerevisiae, and several mammalian cells. At both single cell and population scales, the statistical comparisons between the entire transcriptomes and proteomes show clear correlation structures.

View Article and Find Full Text PDF

Systems Biology Reveals MicroRNA-Mediated Gene Regulation.

Front Genet

October 2012

Institute for Advanced Biosciences, Keio University Tsuruoka, Japan.

MicroRNAs (miRNAs) are members of the small non-coding RNAs, which are principally known for their functions as post-transcriptional regulators of target genes. Regulation by miRNAs is triggered by the translational repression or degradation of their complementary target messenger RNAs (mRNAs). The growing number of reported miRNAs and the estimate that hundreds or thousands of genes are regulated by them suggest a magnificent gene regulatory network in which these molecules are embedded.

View Article and Find Full Text PDF

[Virus, phage, transposon and their regulatory small non-coding RNAs].

Uirusu

June 2011

Institute for Advanced Biosciences, Keio University Tsuruoka, Yamagata 997-0017, Japan.

Many reports have been accumulated describing not a few microRNAs (miRNAs) in eukaryotes target viral genomes, whereas a number of viruses also encode miRNA genes. These small RNAs play important roles on viral infection and their replication. In germ cells, another small RNA, piRNA is reported to repress endogenous transposons.

View Article and Find Full Text PDF

Motivation: Transcription start site selection and alternative splicing greatly contribute to diversifying gene expression. Recent studies have revealed the existence of alternative first exons, but most have involved mammalian genes, and as yet the regulation of usage of alternative first exons has not been clarified, especially in plants.

Results: We systematically identified putative alternative first exon transcripts in rice, verified the candidates using RT-PCR, and searched for the promoter elements that might regulate the alternative first exons.

View Article and Find Full Text PDF