8 results match your criteria: "Keio University Global Research Institute (KGRI)[Affiliation]"

Article Synopsis
  • The COVID-19 pandemic caused significant disruptions in healthcare use in Japan, especially during its later stages (2022-2023), which had not been thoroughly studied before.
  • A quasi-Poisson regression model was used to analyze trends in inpatient and outpatient healthcare utilization in Japan, revealing that inpatient volumes remained consistently lower than pre-pandemic levels and that psychiatric care saw a decline in occupancy rates.
  • The findings indicate that the pandemic has led to lasting changes in healthcare patterns, with reduced inpatient volumes and prolonged psychiatric hospital stays, highlighting the need for ongoing monitoring of healthcare services.
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Article Synopsis
  • The study aims to compare factors influencing knowledge and attitudes about sodium (Na) intake across seven countries to understand their effects and relationships.
  • Using data from a cross-sectional study with over 7,000 participants, researchers found a strong link between knowledge about Na intake and positive attitudes, especially in the UK, France, and the USA.
  • The findings suggest that public health interventions should be culturally and socially tailored, as socioeconomic conditions also play a role in shaping knowledge and attitudes towards Na intake.
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Article Synopsis
  • The paper investigates public attitudes toward salt reduction in seven countries, revealing how cultural differences influence these perceptions.
  • Data from 7090 participants were analyzed using a cross-sectional regression analysis, highlighting significant factors such as gender, age, occupation, and government interventions affecting attitudes towards sodium reduction.
  • The study concludes that attitudes towards sodium reduction are influenced by various factors, indicating a necessity for tailored, country-specific strategies to effectively address sodium intake.
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Background: Two decades have passed since the beginning of the Iraq War in 2003. Iraq has long suffered from conflicts and instability, where the people have limited access to healthcare. The coronavirus disease (COVID-19) pandemic brought additional disruption to health service provision.

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Article Synopsis
  • The study investigates how cancer patients in disaster-affected Fukushima (2011) seek health information online, comparing their behavior with non-cancer patients.
  • 404 patients (263 with cancer and 141 without) were surveyed about their internet use and health information-seeking habits from October 2016 to January 2017.
  • Results showed similar online health information-seeking rates between both groups, but cancer patients who used smartphones and tablets daily were significantly more likely to search for health information; trust in institutional websites was also crucial for them.
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Brain and gut microbes communicate in a bidirectional manner with each affecting a person's response to psychosocial stress. Although human studies demonstrated that the intake of probiotics can alter stress-related behavior in both patients and healthy participants, the association between stress-related brain functions and the gut microbiota has mostly been investigated in patients with depression. However, the response to psychosocial stress differs, even among healthy individuals, and elucidating the natural state of the gut microbiota would broaden the understanding of responses to psychosocial stress.

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Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the safety of NMN in humans have remained unclear.

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Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein.

Stem Cell Reports

February 2019

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:

Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).

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