6 results match your criteria: "Keio University Faculty of Pharmacy Tokyo[Affiliation]"
Chronic kidney disease (CKD) involves progressive renal fibrosis, which gradually reduces kidney function and often causes various complications in extrarenal tissues. Therefore, we investigated fibrogenesis in extrarenal tissues (heart, liver, and lungs) in different experimental CKD models, such as the 5/6-nephrectomy (5/6 Nx), unilateral ureteral obstruction (UUO), and a combination (2/3 Nx + UUO). We evaluated the degree of fibrogenesis in kidneys and extrarenal tissues by histological analysis and quantification of fibrosis-related gene and protein expression.
View Article and Find Full Text PDFRational dosage regimens for cephalothin and cefazolin using pharmacokinetics and pharmacodynamics analysis in healthy horses.
Equine Vet J
November 2021
Clinical Veterinary Medicine Division Equine Research Institute, Japan Racing Association, Shimotsuke, Japan.
Article Synopsis
- First-generation cephalosporins, specifically cephalothin (CET) and cefazolin (CEZ), are commonly used in horses but have limited PK/PD studies conducted.
- The study tested different dosages and discovered that a higher frequency of CET administration is needed to effectively treat S. aureus infections in horses, while a lower frequency is suitable for CEZ.
- The main limitation of the study is that it had a small sample size, focusing only on healthy horses, which may affect the applicability of the findings.
Irinotecan-induced gastrointestinal damage impairs the absorption of dabigatran etexilate.
Biopharm Drug Dispos
November 2019
Division of Clinical Pharmacokinetics, Faculty of Pharmaceutical Sciences, Keio University Faculty of Pharmacy Tokyo, 1-5-30, Shibakoen Minato-ku, Tokyo, 105-8512, Japan.
Irinotecan causes serious gastrointestinal damage. Dabigatran etexilate (DABE), an oral anticoagulant and substrate of P-glycoprotein (P-gp), is poorly absorbed and exhibits low bioavailability in humans. The aim of this study was to evaluate the effects of irinotecan-induced gastrointestinal damage on the pharmacokinetics/pharmacodynamics (PK/PD) of DABE.
View Article and Find Full Text PDFAlterations of epigenetics and microRNAs in cancer and cancer stem cell.
Front Genet
September 2014
Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy Tokyo, Japan.
The aim of this study was to develop a method for predicting the extent of grapefruit juice (GFJ)-drug interactions and their interindividual variations from the pharmacokinetic profile in the absence of GFJ. The pharmacokinetic profiles of 13 drugs after intravenous and oral administration were used to develop and validate the method. For each drug, the proportion absorbed into the intestine and the intestinal availability (Fg ) were calculated from clinical data taken from the literature.
View Article and Find Full Text PDFMicroRNAs in cancers and neurodegenerative disorders.
Front Genet
October 2012
Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy Tokyo, Japan.
MicroRNAs (miRNAs) are small non-coding RNAs which function as endogenous silencers of various target genes. miRNAs are expressed in a tissue-specific manner and playing important roles in cell proliferation, apoptosis, and differentiation during mammalian development. Links between miRNAs and the initiation and progression of human diseases including cancer are becoming increasingly apparent.
View Article and Find Full Text PDF