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A Cross-sectional Study of Regret in Cancer Patients After Sharing Test Results for Pathogenic Germline Variants of Hereditary Cancers With Relatives.
Cancer Nurs
June 2024
Author Affiliations: Department of Nursing, Shizuoka Cancer Center Hospital (Dr Fukuzaki and Ms Suishu); Division of Genetic Medicine Promotion, Shizuoka Cancer Center (Drs Kiyozumi, Horiuchi, and Matsubayashi; Ms Higashigawa; Dr Nishimura); Tokyo Metropolitan Institute of Medical Science (Dr Horiuchi); Division of Endoscopy, Shizuoka Cancer Center (Dr Matsubayashi); Division of Breast Surgery, Shizuoka Cancer Center Hospital (Dr Nishimura); Clinical Research Center, Shizuoka Cancer Center (Drs Mori and Notsu); Shizuoka Cancer Center Research Institute (Ms Ohnami and Dr Kusuhara); and Shizuoka Cancer Center (Dr Yamaguchi), Japan; Department of Biobehavioral Nursing Science, College of Nursing, University of Illinois Chicago (Dr Doorenbos); and Graduate School of Health Management, Keio University (Dr Takeda), Tokyo, Japan.
Background: Research on whole genome/exome sequencing is increasing worldwide. However, challenges are emerging in relation to receiving germline pathogenic variant results and sharing them with relatives.
Objective: The aim of this study was to investigate the occurrence of and reasoning related to regret among patients with cancer who shared single-gene testing results and whole exome sequencing with family members.