2 results match your criteria: "Keenan Research Center for Biomedical Science of Unity Health Toronto[Affiliation]"
Intracellular and Extracellular Lipopolysaccharide Signaling in Sepsis: Avenues for Novel Therapeutic Strategies.
J Innate Immun
January 2022
Keenan Research Center for Biomedical Science of Unity Health Toronto, Toronto, Ontario, Canada.
Sepsis is defined as organ dysfunction due to a dysregulated systemic host response to infection. During gram-negative bacterial infection and other acute illness such as absorption from the gut infection, lipopolysaccharide (LPS) is a major mediator in sepsis. LPS is able to trigger inflammation through both intracellular and extracellular pathways.
View Article and Find Full Text PDFModulation of Human Neutrophil Peptides on Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles.
J Inflamm Res
December 2019
The State Key Laboratory of Respiratory Disease, and The 1st Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Objective: Neutrophil infiltration and release of the abundant human neutrophil peptides (HNP) are a common clinical feature in critically ill patients. We tested a hypothesis that different cell types respond to HNP differently in lung microenvironment that may influence the host responses.
Methods: Plasma concentrations of HNP were measured in healthy volunteers and patients with sepsis.