120 results match your criteria: "Keele University Faculty of Medicine[Affiliation]"

Rheumatoid arthritis (RA) represents an autoimmune condition impacted by a combination of genetic and environmental factors, with the gut microbiome (GMB) being one of the influential environmental factors. Patients with RA display notable modifications in the composition of their GMB, characterised by decreased diversity and distinct bacterial alterations. The GMB, comprising an extensive array of approximately 35,000 bacterial species residing within the gastrointestinal tract, has garnered considerable attention as a pivotal contributor to both human health and the pathogenesis of diseases.

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Introduction: The present meta-analysis compared the efficacy of intra-articular hyaluronic acid (HA) injections in patients with early to mild knee osteoarthritis (OA) (Kellgren Lawrence I-II) versus other commonly injected biologically active compounds using patient-reported outcome measures (PROMs). The outcomes of interest were the visual analogue scale (VAS) and the Western Ontario McMaster Osteo-Arthritis Index (WOMAC) scores.

Methods: This study was conducted according to the 2020 PRISMA statement.

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The impact of smoking in arthroscopic surgery for femoroacetabolar impingement (FAI) is controversial. This systematic review updates and discusses current evidence on the influence of cigarette smoking on the outcome of arthroscopic management of FAI. The outcomes of interest were to compare patient-reported outcome measures (PROMs) and complications.

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Allograft versus autograft ACL reconstruction in skeletally immature patients: a systematic review.

Br Med Bull

December 2024

Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, Via di Grattarossa, 00189 Rome, Italy.

Introduction: Anterior cruciate ligament (ACL) injuries in children and adolescents with open physes are common.

Areas Of Agreement: Evidence of ACL reconstruction using allografts in children with open physes is limited.

Areas Of Controversy: Whether the outcomes of ACL allograft reconstruction in children and adolescents with open physes are superior to autograft ACL reconstruction is unclear, with contrasting evidence.

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: Low back pain is common. For patients with mechanic or non-specific chronic LBP (cLBP), the current guidelines suggest conservative, nonpharmacologic treatment as a first-line treatment. Among the available strategies, physiotherapy represents a common option offered to patients presenting with cLBP.

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Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis.

Eur J Orthop Surg Traumatol

November 2024

Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, 00185, Rome, Italy.

Introduction: Intra-articular injections of ozone and hyaluronic acid (HA) are routinely performed for the management of knee osteoarthritis. The present meta-analysis compared intra-articular injections of HA versus ozone in patients with knee osteoarthritis (OA) in patient-reported outcome measures (PROMs). The outcomes of interest were to determine if intra-articular ozone injections show comparable visual analogue scale (VAS) and Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) scores compared to intra-articular HA injections.

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Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review.

Br Med Bull

November 2024

Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University "La Sapienza" of Rome, Via di Grottarossa 1035, 00189 Roma, Italy.

Introduction: Knee osteoarthritis (OA) is a common degenerative joint condition and a major cause of disability in the general population.

Source Of Data: Recent published literature identified from PubMed, EMBASE, Google Scholar, and Scopus.

Areas Of Agreement: Orthobiological therapies try to regenerate articular cartilage and stop the progression of the degenerative lesion.

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Objectives: To assess the effect of adjuvant antibiotic-loaded hydrogel application on the primary stability of implanted uncemented hip stems.

Design: Biomechanical study.

Setting: An electro-mechanic material test system (#5866, Instron, Norwood, MA, USA) equipped with a 10-kN load cell was used.

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Objectives: This study aims to understand the prevalence, incidence rate, anatomical sites, injury severity and main medical actions carried out during official training and racing by elite downhill mountain biking (DHMTB) riders during the 2023 Union Cycliste Internationale (UCI) Cycling World Championships.

Methods: The participants of this prospective, observational study were elite male and female cyclists competing at the UCI DHMTB World Championships located in the Nevis range in Fort William, Scotland, in 2023. This study followed the injury reporting guidelines established by the International Olympic Committee, which include the Strengthening the Reporting of Observational Studies in Epidemiology-Sports Injury and Illness Surveillance (SIIS) and the cycling-specific extension.

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Article Synopsis
  • Accessible contraception is crucial for women's health, but in the UK, only 55% of pregnancies are planned, with lower usage among ethnic minority women due to barriers like inadequate information and concerns about side effects.
  • A systematic review of studies on ethnic minority women's experiences with contraception revealed four main themes: contraceptive knowledge, beliefs, family influence, and healthcare services.
  • Findings indicate that ethnic minority women share common concerns about side effects, prefer female healthcare providers, and encounter unique challenges, emphasizing the need for culturally sensitive healthcare and better understanding of hormonal hesitancy.
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What are the best antithrombotic prophylaxes following total knee arthroplasty?

Expert Opin Drug Saf

November 2024

Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, Roma, Italy.

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Introduction: Historically, anterior cruciate ligament (ACL) ruptures in the paediatric age group were managed conservatively with bracing, casting, activity modification, and physical therapy. However, most of these patients had to reduce their sports activities, and secondary damages to the affected knee were prevalent.

Source Of Data: Published scientific literature in Embase, Web of Science, PubMed, and Google Scholar databases.

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Introduction: The use of volatile anaesthetic agents for the sedation of patients requiring critical care treatment offers several theoretical advantages over intravenous sedation, which may be of benefit in neurocritical care. However, there are concerns that they may increase intracranial pressure. The objective of this systematic review is to assess whether, and if so, to what extent volatile anaesthetic agents affect intracranial pressure, cerebral blood flow (CBF), cerebral oximetry and cerebrovascular autoregulation.

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Sacroiliac joint pain: what treatment and when.

Expert Rev Neurother

November 2024

Department of Orthopaedic and Trauma Surgery, Academic Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of the Paracelsus Medical University, Bolzano, Italy.

Introduction: Spinal and non-spinal pathologies can cause low back pain. Non-spinal sources of low back pain include the sacroiliac joint (SIJ) and the hip. SIJ pain can be treated either conservatively or surgically.

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Introduction: Spinal cord injury (SCI) may bring lifelong consequences for affected patients and a high financial burden to the health care system.

Source Of Data: Published peer-reviewed scientific articles identified from EMBASE, Google Scholar, PubMed and Scopus.

Areas Of Agreement: Surgery and blood pressure management are the main targets in acute SCI to avoid secondary damage.

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Metamizole, or dipyrone, has been used for decades as a non-narcotic analgesic, providing pain relief from musculoskeletal disorders and antipyretic and antispasmolytic properties. Despite being in use since the 1920s, its mechanism of action still needs to be discovered. Despite causing fewer adverse effects when compared to other analgesics, its harmful effects on the blood and lack of evidence regarding its teratogenicity make the usage of the drug questionable, which has led to it being removed from the drug market of various countries.

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Article Synopsis
  • * This study looked at how well the IPAQ short form (IPAQ-SF) matches the data from the Fibion accelerometer in measuring physical activities and sedentary time among 101 young adults.
  • * Results showed weak correlations between the two methods, indicating that self-reported data may not reliably reflect actual activity levels, suggesting the need for objective measurements with accelerometers instead.
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Angioembolization in the management of joint pain: current concepts.

Orthopadie (Heidelb)

September 2024

Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, 600077, Chennai, Tamil Nadu, India.

Joint pain is a common complaint owing to its origin in inflammatory and degenerative joint diseases. Recent research has helped narrow down inadequate angiogenesis as one of the causes. Angioembolization has emerged as a treatment option for this condition when it is refractory to conservative treatment.

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In recent years, there has been increased interest in the management of medial femorotibial knee osteoarthritis (OA) in conjunction with anterior cruciate ligament (ACL) deficiency. Traditional treatment modalities included conservative therapy, high tibial osteotomy with or without ACL reconstruction, and total knee replacement. Since younger patients with higher physical demands are more likely to suffer from this pathological condition, reduced invasiveness, faster recovery time, and improved knee kinematics are preferred to allow for satisfying clinical and functional outcomes.

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Background: Conservative management is recommended as the first therapeutic step in chronic low back pain (LBP), but there is no available evidence regarding the possible effect of patients' baseline characteristics on the therapeutic outcomes. A systematic review of the literature was performed to investigate this point.

Methods: In February 2024, all the level I studies investigating the role of pharmacological management for chronic LBP were accessed.

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Purpose: The present study evaluated the outcomes of anterior cruciate ligament (ACL) reconstruction in children with open physes. The outcomes of interest were to compare the increase in joint laxity and PROMs from baseline to the last follow-up, the rate and features of the return to sport and the rate of complications.

Methods: This study was conducted according to the 2020 PRISMA guidelines.

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Background: The present systematic review investigated the minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) of several frequent and established PROMs used to assess patients who have undergone TKA. This study was conducted according to the 2020 PRISMA statement.

Methods: In September 2023, PubMed, Web of Science, and Embase were accessed with no time constraint All clinical studies investigating tools to assess the clinical relevance of PROMs used to evaluate patients having received TKA were accessed.

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Antithrombotic prophylaxis following total hip arthroplasty: a level I Bayesian network meta-analysis.

J Orthop Traumatol

January 2024

Department of Orthopaedic, Trauma, and Reconstructive Surgery, BG Klinikum Bergmannstrost Halle, Halle (Saale), Germany.

Background: Several clinical investigations have compared different pharmacologic agents for the prophylaxis of venous thromboembolism (VTE). However, no consensus has been reached. The present investigation compared enoxaparin, fondaparinux, aspirin and non-vitamin K antagonist oral anticoagulants (NOACs) commonly used as prophylaxis following total hip arthroplasty (THA).

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It is unclear whether manual lymphatic drainage (MLD) following primary total knee arthroplasty (TKA) is effective in reducing pain and swelling and improving knee function. The present study investigated the efficacy of MLD after TKA. The outcomes of interest are the range of motion (ROM), pain (visual analogue scale, VAS), and circumference of the lower leg.

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