Fractionation of Boswellia serrata oleogum resin essential oil by short-path molecular vacuum distillation: Unveiling potent biological activities and chemical composition.

Boswellia serrata produces oleo gum resin, a rich source of essential oil (EO). EOs, produced as secondary metabolites by medicinal plants, are employed for medicinal and therapeutic purposes. The present study aimed to investigate the yield, chemical composition, antioxidant (AO), antimicrobial, and hemolytic activity of B.

Online interpersonal trust and online altruistic behavior in college students: the chain mediating role of moral identity and online social support.

Background: The prevalence of online altruistic behaviors among the college students has attracted widespread attention. However, the factors influencing this are still unclear. The objective of this study was to explore the relationship and mechanism of online interpersonal trust, moral identity, online social support and online altruistic behavior among college students.

Radiotherapy and breast cancer: finally, an lncRNA perspective on radiosensitivity and radioresistance.

Radiotherapy (RT) serves as one of the key adjuvant treatments in management of breast cancer. Nevertheless, RT has two major problems: side effects and radioresistance. Given that patients respond differently to RT, it is imperative to understand the molecular mechanisms underlying these differences.

An Adaptive Spiral Strategy Dung Beetle Optimization Algorithm: Research and Applications.

The Dung Beetle Optimization (DBO) algorithm, a well-established swarm intelligence technique, has shown considerable promise in solving complex engineering design challenges. However, it is hampered by limitations such as suboptimal population initialization, sluggish search speeds, and restricted global exploration capabilities. To overcome these shortcomings, we propose an enhanced version termed Adaptive Spiral Strategy Dung Beetle Optimization (ADBO).

Applicability Domain for Trustable Predictions.

In the rapidly evolving landscape of artificial intelligence (AI) and machine learning (ML), understanding and correctly applying the concept of the applicability domain (AD) has emerged as an essential part. This chapter begins with an introduction and background on the critical area of AD. It dives into the definition and different methodologies associated with the applicability domain, laying a solid foundation for further exploration.

Monitoring and enhancing the co-operation of IoT network rhrough scheduling function based punishment reward strategy.

The Internet of Things (IoT) has revolutionized the connectivity of physical devices, leading to an exponential increase in multimedia wireless traffic and creating substantial demand for radio spectrum. Given the inherent scarcity of available spectrum, Cognitive Radio (CR)-assisted IoT emerges as a promising solution to optimize spectrum utilization through cooperation between cognitive and IoT nodes. Unlicensed IoT nodes can opportunistically access licensed spectrum bands without causing interference to licensed users.

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles.

Metal oxide nanoparticles (MONPs) are widely used in medicine and environmental remediation because of their unique properties. However, their size, surface area, and reactivity can cause toxicity, potentially leading to oxidative stress, inflammation, and cellular or DNA damage. In this study, a nano-quantitative structure-toxicity relationship (nano-QSTR) model was initially developed to assess zebrafish toxicity for 24 MONPs.

Moonlighting Crypto-Enzymes and Domains as Ancient and Versatile Signaling Devices.

Increasing numbers of reports have revealed novel catalytically active cryptic guanylate cyclases (GCs) and adenylate cyclases (ACs) operating within complex proteins in prokaryotes and eukaryotes. Here we review the structural and functional aspects of some of these cyclases and provide examples that illustrate their roles in the regulation of the intramolecular functions of complex proteins, such as the phytosulfokine receptor (PSKR), and reassess their contribution to signal generation and tuning. Another multidomain protein, K uptake permease (AtKUP5), also harbors multiple catalytically active sites including an N-terminal AC and C-terminal phosphodiesterase (PDE) with an abscisic acid-binding site.

Fostering resilience and post-traumatic growth in overseas Chinese left-behind children: The role of autonomy, competence, and relatedness.

Objective: This study examines the impact of parental migration on the psychological well-being and development of left-behind children (LBCs) in Zhejiang, China, within the broader context of the country's rural transformations and urban migration. It investigates how intellectual and relational engagement (RE), autonomy (AUT), competence (COM), and relatedness (RES) contribute to resilience (REL) and post-traumatic growth (PTG) in these children, reflecting on the shift from viewing parental separation merely as a source of trauma to recognizing its potential to foster significant personal growth.

Methods: Utilizing a cross-sectional design, the research was conducted in April and May 2023 with 1348 LBCs from a total sample of 4049 students inZhejiang.

Interprofessional Collaboration and Self-Compassion Intervention for School-Based Practitioners: A Mixed-Methods Analysis.

Aims: To evaluate a five-month, hybrid, districtwide interprofessional collaboration and self-compassion training-and-coaching intervention.

Methods: Following a full-day interprofessional training in a large urban, K-through-12, Southern U.S.

Metabolite release by nitrifiers facilitates metabolic interactions in the ocean.

Microbial chemoautotroph-heterotroph interactions may play a pivotal role in the cycling of carbon in the deep ocean, reminiscent of phytoplankton-heterotroph associations in surface waters. Nitrifiers are the most abundant chemoautotrophs in the global ocean, yet very little is known about nitrifier metabolite production, release, and transfer to heterotrophic microbial communities. To elucidate which organic compounds are released by nitrifiers and potentially available to heterotrophs, we characterized the exo- and endometabolomes of the ammonia-oxidizing archaeon Nitrosopumilus adriaticus CCS1 and the nitrite-oxidizing bacterium Nitrospina gracilis Nb-211.

Perturbation walking effects on prefrontal cortical activation and walking performance in older women with and without osteoarthritis: a FNIRS study.

Introduction: Perturbation walking (PW) has been shown to improve gait, however its effect on the cortical control of gait might provide insights on neural mechanisms underlying falls in adults with osteoarthritis. The objective of this study is to investigate the effect of PW on prefrontal cortical (PFC) activation in older women with (OA) and without osteoarthritis (HOA). We hypothesized that there would be an increase in PFC activation during PW relative to comfortable walking (CW) and higher increase in PFC activation during PW in HOA compared to OA.

Facultative Parthenogenesis in a Zoo-Held Northern Water Snake, Nerodia sipedon.

Over the past several decades, facultative parthenogenesis (FP)-the ability of a sexually reproducing species to reproduce asexually-in vertebrates has been removed from the realm of obscurity and placed firmly in a position where it warrants focused scientific attention. Likely fueled by increased recognition of the trait, the availability of molecular tools capable of disentangling FP from long-term sperm storage, and the availability of potential cases originating from both zoological and private collections, a wealth of papers has been published revealing the diversity of vertebrate systems in which FP occurs. Specifically, cases have been reported in squamate reptiles (lizards and snakes), crocodiles, birds, and elasmobranch fishes (sharks, rays, and skates).

Molecular similarity in chemical informatics and predictive toxicity modeling: from quantitative read-across (q-RA) to quantitative read-across structure-activity relationship (q-RASAR) with the application of machine learning.

This article aims to provide a comprehensive critical, yet readable, review of general interest to the chemistry community on molecular similarity as applied to chemical informatics and predictive modeling with a special focus on read-across (RA) and read-across structure-activity relationships (RASAR). Molecular similarity-based computational tools, such as quantitative structure-activity relationships (QSARs) and RA, are routinely used to fill the data gaps for a wide range of properties including toxicity endpoints for regulatory purposes. This review will explore the background of RA starting from how structural information has been used through to how other similarity contexts such as physicochemical, absorption, distribution, metabolism, and elimination (ADME) properties, and biological aspects are being characterized.

Making Sense of the COVID-19 Pandemic: The Use of Blogging by People with Inflammatory Bowel Disease.

During the global COVID-19 pandemic one population that faced special challenges was individuals with preexisting chronic health conditions. In this study, we examined how people with inflammatory bowel disease (IBD) managed their autoimmune disease, considering their increased susceptibility to contracting COVID-19. Specifically, we analyzed how people with IBD made sense of their precarious position through the writing of publicly accessible blogs.

A taxon-restricted duplicate of Iroquois3 is required for patterning the spider waist.

The chelicerate body plan is distinguished from other arthropod groups by its division of segments into 2 tagmata: the anterior prosoma ("cephalothorax") and the posterior opisthosoma ("abdomen"). Little is understood about the genetic mechanisms that establish the prosomal-opisthosomal (PO) boundary. To discover these mechanisms, we created high-quality genomic resources for the large-bodied spider Aphonopelma hentzi.

Challenges in LncRNA Biology: Views and Opinions.

This is a mini-review capturing the views and opinions of selected participants at the 2021 IEEE BIBM 3rd Annual LncRNA Workshop, held in Dubai, UAE. The views and opinions are expressed on five broad themes related to problems in lncRNA, namely, challenges in the computational analysis of lncRNAs, lncRNAs and cancer, lncRNAs in sports, lncRNAs and COVID-19, and lncRNAs in human brain activity.

Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond.

Glioblastoma multiforme (GBM) is one of the deadliest human cancers with very limited treatment options available. The malignant behavior of GBM is manifested in a tumor which is highly invasive, resistant to standard cytotoxic chemotherapy, and strongly immunosuppressive. Immune checkpoint inhibitors have recently been introduced in the clinic and have yielded promising results in certain cancers.

In Silico Analysis of Calotropis procera-Derived Phytochemicals Targeting 3CL Proteoase of SARS-CoV-2.

The coronavirus known as SARS-CoV-2 has enveloped virions with single-stranded positive-sense RNA genome. It infects mammals, including humans, via the respiratory tract. The non-structural protein of coronavirus, main protease (3CLp) is a key enzyme in the disease's progression.

Marine particle size-fractionation indicates organic matter is processed by differing microbial communities on depth-specific particles.

Passive sinking flux of particulate organic matter in the ocean plays a central role in the biological carbon pump and carbon export to the ocean's interior. Particle-associated microbes colonize particulate organic matter, producing "hotspots" of microbial activity. We evaluated variation in particle-associated microbial communities to 500 m depth across four different particle size fractions (0.

Communication Training within : Feasibility, Acceptability, and Usability.

is a consultation model adapted from Conjoint Behavioral Consultation where parents and teachers identify a mutual concern for children with Autism and then implement the same evidence-based practices (EBPs) across home and school. Adding parent-teacher communication training () may bolster the effects of this consultation approach. The purpose of this study was to explore parents' and teachers' experiences with , as well as examine the clinical outcomes of plus Participants were 21 parents and 21 teachers (n=21 dyads, N=42 participants) of preschool to first-grade children with Autism.

Use of Interactive Food Labels to Increase Confidence in Preparing Produce among College Students.

College students may have limited access to produce and may lack confidence in preparing it, but cooking videos can show how to make healthy dishes. The Cognitive Theory of Multimedia Learning suggests that learning is enhanced when visual and auditory information is presented considering cognitive load (e.g.