Two novel HLA-DQB1 alleles identified in potential hematopoietic stem cell donors: DQB1*03:01:50 and -DQB1*03:453.

HLA-DQB1*03:01:50 and -DQB1*03:453, two novel alleles detected by next generation sequencing.

The detection of three novel HLA-DQB1 alleles: HLA-DQB1*02:186, -DQB1*06:02:49 and -DQB1*06:391.

Three novel HLA-DQB1 alleles HLA-DQB1*02:186, -DQB1*06:02:49, and -DQB1*06:391 alleles detected during routine next generation sequencing.

Characterization of the novel HLA-DQB1*05:277 allele, detected in two unrelated bone marrow donors.

HLA-DQB1*05:277 has one non-synonymous nucleotide change from DQB1*05:01:01:03 at codon 224.

The novel HLA-A*02:1009 allele was identified in four unrelated bone marrow donors.

HLA-A*02:1009 has one non-synonymous nucleotide change from A*02:01:01:01 at codon 320.

Mucosal Immunity After Novel COVID-19 Infection - Virus-Induced Immunosuppression: Preliminary Study.

In recovered COVID-19 patients, the state of mucosal immunity remains understudied. Cytological, functional, and metabolic characteristics of neutrophils and the interleukin status will help to correctly assess the need for immunorehabilitation measures. The study objective is to assess the state of mucosal immunity after COVID-19.

Pollen data from bottom sediments of a tundra lake in the Yerkuta River basin on the Yamal Peninsula.

This article extends the findings of our previous research "Preliminary reconstruction of climate changes and vegetation cover inferred from pollen study of the arctic lake bottom sediments from the southwestern part of the Yamal Peninsula" (G.R. Nigamatzyanova, N.

Statistical precursors of a strong earthquake on April 6, 2009 on the Apennine Peninsula.

The article discusses the possibility of formulating a conclusion about the transition in early April 2009 to an exceptional state of the geophysical system in an area with a radius of about several hundred kilometers from Rome. This fact preceded the tragic earthquake on April 6, 2009, which led to large casualties in the Italian city of L'Aquila. This conclusion was obtained based on an analysis of the statistics of the critical frequency of the ionosphere.

The identification of three novel HLA-C alleles: HLA-C*01:218, HLA-C*03:550 and HLA-C*05:01:60.

Three novel HLA-C alleles HLA-C*01:218, -C*03:550 and -C*05:01:60 alleles detected during routine next generation sequencing.

[Effectiveness of the anxiolytic Anvifen in the treatment of post-COVID brain fog].

Objective: To determine the significance of anxiety disorder and comorbid disorders in patients with post-covid brain fog, to determine the effectiveness of the GABAergic nootropic drug with an anxiolytic effect - Anvifen.

Material And Methods: 92 post-COVID-19 patients with no organic brain damage who complain of brain fog 12 weeks after the onset of COVID-19 symptoms. Group 1 (=40; 43.

Polysiloxane Coatings Biodeterioration in Nature and Laboratory.

Objects and structures made of organic glass require protection from damage caused by external factors. Light, humidity, temperature, dust pollution and, undoubtedly, microorganisms lead to the deterioration of optical and mechanical properties. Polysiloxane-based protective coatings, consisting of silicon-oxygen backbones linked together with organic side groups attached to the silicon atoms, are widely used.

Effect of Melanization on Thallus Microstructure in the Lichen .

Lichens often grow in microhabitats where they experience severe abiotic stresses. Some species respond to high UV radiation by synthesizing dark brown melanic pigments in the upper cortex. However, unlike the melanized structures of non-lichenized fungi, the morphology of the melanic layer in lichens remains unstudied.

Bacillus pumilus proteome changes in response to 2,4,6-trinitrotoluene-induced stress.

2,4,6-Trinitrotoluene (TNT) is the most widely used nitroaromatic compound and is highly resistant to degradation. Most aerobic microorganisms reduce TNT to amino derivatives via formation of nitroso- and hydroxylamine intermediates. Although pathways of TNT degradation are well studied, proteomic analysis of TNT-degrading bacteria was done only for some individual Gram-negative strains.

Enhancement of the Transdermal Delivery of Nonsteroidal Anti-inflammatory Drugs Using Liposomes Containing Cationic Surfactants.

New hybrid liposomes based on cationic amphiphiles with different structures of the head group (cetyltrimethylammonium bromide (CTAB), 3-hexadecyl-1-hydroxyethylimidazolium bromide (IA-16(OH)), 1-(butylcarbamoyl)oxyethyl-3-hexadecylimidazolium bromide (IAC 16(Bu)), and hexadecylmethylpyrrolidinium bromide (PR-16)) were developed for transdermal administration of nonsteroidal anti-inflammatory drugs. The different surfactant/lipid compositions were studied to obtain stable liposomes with high functionality. The hydrodynamic diameter of cationic liposomes was ∼110 nm.

Three novel HLA-C alleles identified in Russian individuals: HLA-C*12:346, -C*05:01:66, and -C*07:955.

Three novel HLA-C alleles were identified during routine next-generation sequencing.

The novel HLA-C*06:327 allele was identified in three unrelated bone marrow donors.

HLA-C*06:327 has one non-synonymous nucleotide change from C*06:02:01:01 at codon 222.

Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation.

In this review, we explore systemization of knowledge about the triggering effects of non-genetic factors in pathogenic mechanisms that contribute to the development of rheumatoid arthritis (RA). Possible mechanisms involving environmental and individual factors in RA pathogenesis were analyzed, namely, infections, mental stress, sleep deprivation ecology, age, perinatal and gender factors, eating habits, obesity and smoking. The non-genetic factors modulate basic processes in the body with the impact of these factors being non-specific, but these common challenges may be decisive for advancement of the disease in the predisposed body at risk for RA.

Anaerobic Digestion of Chicken Manure in the Presence of Magnetite, Granular Activated Carbon, and Biochar: Operation of Anaerobic Reactors and Microbial Community Structure.

The influence of magnetite nanoparticles, granular activated carbon (GAC), and biochar, as well as their combinations on the anaerobic digestion of chicken manure and the structure of microbial communities was studied. The addition of magnetite, GAC, and biochar increased the rate of methane production and the total methane yield. It has been observed that these additives stimulated anaerobic microorganisms to reduce the concentration of accumulated volatile organic acids.

Structural and ultrastructural changes in the skeletal muscles of dysferlin-deficient mice during postnatal ontogenesis.

A number of sarcolemma proteins are responsible for muscle fiber repair. Dysferlin encoded by the gene is one of these proteins. Dysferlin promotes membrane repair in striated muscle fibers (MFs).

Alternative transcription start sites contribute to acute-stress-induced transcriptome response in human skeletal muscle.

Background: More than half of human protein-coding genes have an alternative transcription start site (TSS). We aimed to investigate the contribution of alternative TSSs to the acute-stress-induced transcriptome response in human tissue (skeletal muscle) using the cap analysis of gene expression approach. TSSs were examined at baseline and during recovery after acute stress (a cycling exercise).

Role of PSS-based assemblies in stabilization of Eu and Sm luminescent complexes and their thermoresponsive luminescence.

The present work introduces self-assembled polystyrenesulfonate (PSS) molecules as soft nanocapsules for incorporation of Eu-Sm complexes by the solvent exchange procedure. The high levels of Eu- and Sm-luminescence of the complexes derives from the ligand-to-metal energy transfer, in turn, resulted from the complex formation of Euand Sm ions with the three recently synthesized cyclophanic 1,3-diketones. The structural features of the ligands are optimized for the high thermal sensitivity of Eu- luminescence in DMF solutions.

Is icosahedral short-range order presented in supercooled transition metals?

Supercooled transition metals are characterized by the absence of long-range order and the presence of a specific short-range order in the arrangement of atoms. So, the presence of shoulders and broadenings at the second maximum in the experimentally measured quantity-in the static structure factor()-is usually interpreted as a manifestation of the icosahedral (ideal or distorted) short-range order (ISRO-). Icosahedral short-range order is a structure with fivefold symmetry in the arrangement of atoms, which can lead to the possibility of achieving deep supercooling.

Novel Budesonide Suppository and Standard Budesonide Rectal Foam Induce High Rates of Clinical Remission and Mucosal Healing in Active Ulcerative Proctitis: a Randomised, Controlled, Non-inferiority Trial.

Background And Aims: Proctitis is the least extensive type of ulcerative colitis, for which rectal therapy is rarely studied and is underused. This study evaluated the efficacy, safety, and patient's preference of a novel formulation of budesonide suppository 4 mg, compared with a commercially available budesonide rectal foam 2 mg, for the treatment of mild to moderate ulcerative proctitis.

Methods: This was a randomised, double-blind, double-dummy, active-controlled trial.

Acute behavioral and Neurochemical Effects of Novel -Benzyl-2-Phenylethylamine Derivatives in Adult Zebrafish.

Hallucinogenic drugs potently affect brain and behavior and have also recently emerged as potentially promising agents in pharmacotherapy. Complementing laboratory rodents, the zebrafish () is a powerful animal model organism for screening neuroactive drugs, including hallucinogens. Here, we test a battery of ten novel -benzyl-2-phenylethylamine (NBPEA) derivatives with the 2,4- and 3,4-dimethoxy substitutions in the phenethylamine moiety and the -OCH, -OCF, -F, -Cl, and -Br substitutions in the position of the phenyl ring of the -benzyl moiety, assessing their acute behavioral and neurochemical effects in the adult zebrafish.

Genomic and metabolomic profiling of endolithic Rhodococcus fascians strain S11 isolated from an arid serpentine environment.

Genomic and metabolomic studies of endolithic bacteria are essential for understanding their adaptations to extreme conditions of the rock environment and their contributions to mineralization and weathering processes. The endoliths of arid serpentine rocks are exposed to different environmental stresses, including desiccation and re-hydration, temperature fluctuations, oligotrophy, and high concentrations of heavy metals. Bacteria of the genus Rhodococcus commonly inhabit endolithic environments.

The novel HLA-DQB1 allele, HLA-DQB1*04:72, detected in a potential hematopoietic stem cell donor.

Identification of the novel HLA-DQB1*04:72 allele that differs from DQB1*04:02:01:06 by two nucleotide substitutions.