A comprehensive analysis of advanced solar panel productivity and efficiency through numerical models and emotional neural networks.

This study presents an in-depth analysis and evaluation of the performance of a standard 200 W solar cell, focusing on the energy and exergy aspects. A significant research gap exists in the comprehensive integration of numerical models with advanced machine-learning approaches, specifically emotional artificial neural networks (EANN), to simulate and optimize the electrical characteristics and efficiency of solar panels. To address this gap, a numerical model alongside a novel EANN was employed to simulate the system's electrical characteristics, including open-circuit voltage, short-circuit current, system resistances, maximum power point characteristics, and characteristic curves.

Revisiting the genus (Liliaceae) in Kazakhstan, the country with the richest tulip diversity worldwide.

The genus L., belonging to the Liliaceae family, has significant economic, horticultural, and ecological importance and is culturally revered in various regions worldwide. The total number of species, including 90-120 taxa, varies based on different sources.

Comparison of baseline global gene expression profiles of prostate cancer cell lines LNCaP and DU145.

Introduction: DU145 and LNCaP are classic prostate cancer cell lines. Characterizing their baseline transcriptomics profiles (without any intervention) can offer insights into baseline genetic features and oncogenic pathways that should be considered while interpreting findings after various experimental interventions such as exogenous gene transfection or drug treatment.

Methods: LNCaP and DU145 cell lines were cultured under normal conditions, followed by RNA extraction, cDNA conversion, library preparation, and RNA sequencing using the Illumina NovaSeq platform.

Tackling the primary healthcare workforce crisis: time to talk about health systems and governance-a comparative assessment of nine countries in the WHO European region.

Background: Primary healthcare has emerged as a powerful global concept, but little attention has been directed towards the pivotal role of the healthcare workforce and the diverse institutional setting in which they work. This study aims to bridge the gap between the primary healthcare policy and the ongoing healthcare workforce crisis debate by introducing a health system and governance approach to identify capacities that may help respond effectively to the HCWF crisis in health system contexts.

Methods: A qualitative comparative methodology was employed, and a rapid assessment of the primary healthcare workforce was conducted across nine countries: Denmark, Germany, Kazakhstan, Netherlands, Portugal, Romania, Serbia, Switzerland, and the United Kingdom/ England.

Use of platelet-rich plasma in rheumatic diseases.

Platelet-rich plasma (PRP) has gained increasing recognition as a promising therapeutic agent in managing rheumatic diseases. Conventional treatments, including nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying antirheumatic drugs (DMARDs), primarily act on reducing inflammation but fail to address the underlying mechanisms of connective tissue degradation. PRP, an autologous preparation enriched with growth factors and bioactive molecules, is pivotal in modulating inflammation and fostering tissue regeneration.

Magnesium and silicon recovery from chrysotile asbestos waste of the deposit Zhitikara, Kazakhstan.

Waste generated during asbestos manufacturing contains substantial quantities of iron, nickel, magnesium, and silicon. The existing techniques for processing chrysotile-asbestos waste (CAW) cannot fully recover these elements. Therefore this paper presents a hydrometallurgical method for processing the CAW of the Zhitikara deposit in the Kostanay region of Kazakhstan.

Tinnitus prevalence and care experience among population of Almaty city.

Unlabelled: The prevalence of tinnitus is increasing worldwide along with the aging population. The absence of a gold standard for diagnosis and treatment makes it difficult to assess the health status of a patient with tinnitus.The aim was to determine the prevalence of tinnitus among older adults in Almaty city and to evaluate the healthcare experience among the respondents who received treatment for tinnitus.

Analysis of the Effectiveness and Coverage of Breast, Cervical, and Colorectal Cancer Screening Programs in Kazakhstan for the Period 2021-2023: Regional Disparities and Coverage Dynamics.

Background: Cancer screening is a crucial component in the fight to reduce cancer incidence and mortality. Currently, the WHO recommends highly effective cancer screening programs, including screening for cervical cancer (CC), breast cancer (BC), and colorectal cancer (CRC). Despite the implementation of a cancer screening program since 2014, an evaluation of the effectiveness of BC, CC, and CRC screening in the Kazakhstan has not yet been conducted.

Association of B-Lineage Lymphoblastic Leukaemia Gene Polymorphisms with Poor Prognostic Features.

Objective: Of this study was to analyse the correlation of gene polymorphisms with clinical and laboratory data of paediatric patients with B-lineage acute lymphoblastic leukaemia with prognostically unfavourable features.

Methods: A study of 200 children with B-lineage acute lymphoblastic leukaemia (B-ALL) treated with polychemotherapy programmes was conducted. Analysis by sex revealed a statistically insignificant predominance of the group of boys over girls (54%).

Assessment of Hematological Toxicity of Adjuvant Chemotherapy in the Complex Therapy of Breast Cancer.

Within the framework of multicenter clinical studies of the original anticancer drug "Arglabin" in the complex therapy of breast cancer (BC) in an increased dose on the basis of the Regional Oncological Dispensary, Karaganda, 80 patients BC were examined and treated: 40 patients in the control group and 40 in the study group. The index of grade I anemia was higher in patients of the control group: in (15.6±6.

COVID-19 is a trigger of autoimmune rheumatic diseases: a hypothesis tested over time.

We discuss the paper recently published in Rheumatology Internationa. This article reflects on the prevalence of autoimmune rheumatic diseases (ARD) during the COVID-19 pandemic (2020-2023) and compares the same with the pre-pandemic period (2016-2019). We assume that SARS-CoV-2 triggers ARD.

Estimation of the wetting induced settlement of loess soils from the wetting soil-water characteristic curve.

Collapsible loess soils, known for their significant volume reduction upon the wetting, pose critical challenges in the geotechnical engineering. The estimation of the wetting-induced settlement is crucial for the foundation design and the determination of the negative skin friction on the pile. In this paper, a new method is proposed to estimate the wetting induced collapse from the wetting soil-water characteristic curve (SWCC) and the index properties of the loess soils.

Water-based interventions in rheumatic diseases: mechanisms, benefits, and clinical applications.

Chronic pain and restricted mobility, hallmark features of rheumatic diseases, substantially affect patients' quality of life, often resulting in physical disability and emotional distress. Given the long-term nature of these conditions, there is a growing interest in complementary therapeutic approaches, emphasizing the need to explore non-pharmacological treatments. Hydrotherapy, balneotherapy, and mud therapy have emerged as effective interventions to alleviate pain, reduce inflammation, improve joint mobility, and enhance overall physical and mental well-being.

Conceptual understanding and cognitive patterns construction for physical education teaching based on deep learning algorithms.

To improve students' understanding of physical education teaching concepts and help teachers analyze students' cognitive patterns, the study proposes an association learning-based method for understanding physical education teaching concepts using deep learning algorithms, which extracts image features related to teaching concepts using convolutional neural networks. Moreover, a neurocognitive diagnostic model based on hypergraph convolution is constructed to mine the data of students' long-term learning sequences and identify students' cognitive outcomes. The findings revealed that the highest accuracy of the association graph convolutional neural network was 0.

Evaluating ChatGPT's Multilingual Performance in Clinical Nutrition Advice Using Synthetic Medical Text: Insights from Central Asia.

Background: Although large language models like ChatGPT-4 have demonstrated competency in English, their performance for minority groups speaking underrepresented languages, as well as their ability to adapt to specific sociocultural nuances and regional cuisines, such as those in Central Asia (for example, Kazakhstan), still requires further investigation.

Objectives: To evaluate and compare the effectiveness of the ChatGPT-4 system in providing personalized, evidence-based nutritional recommendations in English, Kazakh, and Russian in Central Asia.

Methods: This study was conducted from 15 May to 31 August, 2023.

[Modern aspects of chronic cerebral ischemia pathogenetic therapy].

Chronic cerebral ischemia (CCI) is one of the most common forms of cerebrovascular disease, which affects a significant number of patients, often leading to disability, cognitive impairment and dementia. The analysis of modern data on the pathogenesis and risk factors for the development of CCI, as well as on the mechanisms of action of Mexidol on various links in the pathogenesis of CCI. A systematic search was conducted in the PubMed, MEDLINE and Google Scholar databases, on Russian and English-language sites with open access publications on the problem of CCI and on the drug Mexidol in the period from 2014 to 2024.

In Vitro conservation and genetic diversity analysis of rare species Ribes janczewskii.

Ribes janczewskii is a rare and valuable plant known for its resistance to spring frosts, pests, and diseases. It is used in hybridization to develop resistant currant varieties but is on the verge of extinction, listed in Kazakhstan Red Book. This study developed a micropropagation and slow-growth storage protocol for conservation.

Effect of Different Thawing Regimes on Cell Kinematics and Organelle Integrity of Nitrogen-Stored Wallachian Ram Spermatozoa.

Artificial insemination is an advanced reproductive technology used to increase the number of lambs born from elite sires to accelerate genetic gain in a flock [...

Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies.

Post-Traumatic Stress Disorder (PTSD) is a multifaceted psychiatric disorder triggered by traumatic events, leading to prolonged psychological distress and varied symptoms. Rat models have been extensively used to explore the biological, behavioral, and neurochemical underpinnings of PTSD. This review critically examines the strengths and limitations of commonly used rat models, such as single prolonged stress (SPS), stress-re-stress (S-R), and predator-based paradigms, in replicating human PTSD pathology.

Placental Macrovascular Pattern from Pregnancies with Maternal Hypertensive and Fetal Growth Capacity Complications.

Unlabelled: Histomorphometric measurements of the wall thickness and internal diameter of the macrovessels of the chorionic villi of placentas from pregnancies complicated by preeclampsia or fetal growth restriction in comparison with normotensive pregnancy.

Methods: The research included placentas from singleton pregnancies complicated by preeclampsia and/or fetal growth restriction, women delivered in medical institutions in Karaganda city (Kazakhstan). Placentas were divided into three groups: PE ( = 59), isolated FGR ( = 24), and PE with FGR ( = 41).

Nanostructured Hydrogels of Carboxylated Cellulose Nanocrystals Crosslinked by Calcium Ions.

Bio-based eco-friendly cellulose nanocrystals (CNCs) gain an increasing interest for diverse applications. We report the results of an investigation of hydrogels spontaneously formed by the self-assembly of carboxylated CNCs in the presence of CaCl using several complementary techniques: rheometry, isothermal titration calorimetry, FTIR-spectroscopy, cryo-electron microscopy, cryo-electron tomography, and polarized optical microscopy. Increasing CaCl concentration was shown to induce a strong increase in the storage modulus of CNC hydrogels accompanied by the growth of CNC aggregates included in the network.

Prospects for Treatment of Lung Cancer Using Activated Lymphocytes Combined with Other Anti-Cancer Modalities.

This review explores the significance and prospects of using diverse T-cell variants in the context of combined therapy for lung cancer treatment. Recently, there has been an increase in research focused on understanding the critical role of tumor-specific T lymphocytes and the potential benefits of autologous T-cell-based treatments for individuals with lung cancer. One promising approach involves intravenous administration of ex vivo-activated autologous lymphocytes to improve the immune status of patients with cancer.

Association of infection with colorectal cancer in Kazakhstani patients.

Objectives: is a gram-negative anaerobic bacillus associated with colorectal cancer (CRC). We aimed to determine the abundance of . and other CRC-associated bacteria using quantitative real-time polymerase chain reaction (qPCR) analysis to detect the possible correlations between tumor and normal tissues and the relationships between patients' clinical characteristics, diet, and CRC-associated bacteria.