11,240 results match your criteria: "Kazakhstan; M.A. Aitkhozhin's Institute of Molecular Biology and Biochemistry[Affiliation]"

Objective: To explain older rural women's participation in clinical decision-making with GPs and explore factors associated with their pre-visit planning and involvement in treatment processes.

Methods: A sequential, theory-driven mixed-method study was conducted. Women aged 65 years or above who had visited a GP three months prior were recruited from five rural towns in South Australia through the local Rotary Club.

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The coronavirus that causes serious acute respiratory syndrome. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still a major problem in public health and biomedicine. Even if there is no cure for it, the infection is still progressing naturally, and the only time that optimal treatment choices, such as doxycycline, work is at the beginning of the infection.

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The paper presents data on the complex processing of large-tonnage waste from oil and gas industry and chemical production, as well the methods of their utilization and processing. The data was collected at the industrial sites of the plants in Western Kazakhstan. During the work, there were studied data on the chemical composition of the waste, properties of the experimental compositions, material structure, and peculiarities of the technological processes of recycling.

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Rhazes' insights on abortion and abortogenic drugs in relation to modern concepts.

Naunyn Schmiedebergs Arch Pharmacol

December 2024

Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Abortion remains one of the most prevalent complications of pregnancy, contributing significantly to maternal mortality and presenting a substantial public health challenge. This study aimed to explore Rhazes' perspective on abortion and abortifacient medicinal plants he mentioned in Kitāb al-Ḥāwī fī al-Ṭibb. A detailed analysis of his seminal work, Kitāb al-Ḥāwī fī al-Ṭibb, was conducted.

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Three new monoterpenes compounds isolated from Seriphidium terrae-albae exerted anti-inflammatory effects through the JAK/STAT and NF-κB signaling pathways.

Fitoterapia

January 2025

State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China. Electronic address:

Three new monoterpenes compounds (5S, 8S)-5-(2E-butenyl)-8-methyl propionate-cyclopentanone (1), 1-Oxy, 10-keto-α-myrcene hydroxide (2), (3R,4R)-3-hydroxy-4-isobutenyl-cyclopentyl ester (3), along with eleven known small molecular compounds such as monoterpenes (1-7, 14), coumarin (10), and other small molecular compounds (8, 9, 11-13) were isolated from Seriphidium terrae-albae. The structures were elucidated by NMR, HRESIMS, ECD calculations, and X-ray crystallography. Anti-inflammatory activity test results showed that 9 compounds were detected to inhibit NO secretion by mouse macrophage Raw 264.

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Nursing students' perceptions of patient safety culture and barriers to reporting medication errors: A cross-sectional study.

Nurse Educ Today

December 2024

Maternal and Child Nursing Department, College of Nursing, University of Hail, Hail 2440, Saudi Arabia; Department of Nursing, College of Health Sciences, University of Fujairah, Fujairah 1207, United Arab Emirates. Electronic address:

Background: Patient safety is critical to high-quality patient care. However, it is liable to medication errors (MEs).

Objective: Therefore, this study assessed perceptions of patient safety culture (PSC) and barriers to reporting MEs among nursing students in Hail City, Saudi Arabia.

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The gut-brain-metabolic axis has emerged as a critical area of research, highlighting the intricate connections between the gut microbiome, metabolic processes, and cognitive function. This review article delves into the complex interplay between these interconnected systems, exploring their role in the development of insulin resistance and cognitive decline. The article emphasizes the pivotal influence of the gut microbiota on central nervous system (CNS) function, demonstrating how microbial colonization can program the hypothalamic-pituitary-adrenal (HPA) axis for stress response in mice.

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Background: The 2022 WHO guidelines on multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) recommend six months of bedaquiline (Bdq) in the all-oral 9-month shorter regimen and six months or longer for Bdq and delamanid (Dlm) in the 18-20-month longer regimen. However, lack of evidence on extended treatment using Bdq or Dlm has limited their use to six months. We examine the frequency and incidence of QT prolongation based on duration of Bdq and/or Dlm use in longer regimens.

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An virus strain, ), was isolated in Karaganda, Central Kazakhstan during a study of acute respiratory infections among hospital inpatients in 2022. Here, we present the complete genome sequence of this strain.

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Octahedral Iron in Catalytic Sites of Endonuclease IV from and .

Biochemistry

January 2025

Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

Article Synopsis
  • - During infections, reactive oxygen species can cause DNA damage, necessitating a repair process that involves the enzyme endonuclease IV (Nfo), which removes defective DNA bases through hydrolysis.
  • - The crystal structure of Nfo from a Gram-positive organism shows that it contains two iron ions and one zinc ion, with unique water molecule coordination that may play a role in how the enzyme distinguishes between these metals.
  • - Nfo exhibits slow product release and optimal activity at high salt concentrations, which ties into its function and potentially significant role in organisms that thrive in salty environments.
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Gut metagenomic features of frailty.

Front Cell Infect Microbiol

December 2024

Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.

This study investigates the relationship between frailty severity and gut microbiome characteristics in adults in Kazakhstan. We analyzed 158 participants across four frailty severity (mild to very severe) using metagenomic sequencing of stool samples. Frailty was significantly correlated with age, weight, and functional measures like walking speed and grip strength.

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Hepatitis E virus (HEV; family ) infections cause >40,000 human deaths annually. Zoonotic infections predominantly originate from ungulates and occasionally from rats, highlighting the zoonotic potential of rodent-associated hepeviruses. We conducted host genomic data mining and uncovered two genetically divergent rodent-associated hepeviruses, and two bat-associated hepeviruses genetically related to known bat-associated strains.

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Accurately assessing congenital heart disease using artificial intelligence.

PeerJ Comput Sci

November 2024

Department of Computer Science, School of Engineering and Digital Sciences, Nazarbayev University, Astana, Kazakhstan.

Congenital heart disease (CHD) remains a significant global health challenge, particularly contributing to newborn mortality, with the highest rates observed in middle- and low-income countries due to limited healthcare resources. Machine learning (ML) presents a promising solution by developing predictive models that more accurately assess the risk of mortality associated with CHD. These ML-based models can help healthcare professionals identify high-risk infants and ensure timely and appropriate care.

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A New Neuroanesthetic Protocol of Rendering Specialized Care in Treating Degenerative Lumbar Spine Diseases in High-Risk Patients: Prospective Analysis of the Results.

Sovrem Tekhnologii Med

December 2024

MD, DSc, Professor, Head of the Department of Neurosurgery and Innovative Medicine; Irkutsk State Medical University, 1 Krasnogo Vosstaniya St., Irkutsk, 664003, Russia; Chief of the Center of Neurosurgery; Russian Railways-Medicine Clinical Hospital, 10 Botkin St., Irkutsk, 664005, Russia; Professor, Department of Traumatology, Orthopedics and Neurosurgery; Irkutsk State Medical Academy of Postgraduate Education, 100 Yubileyny Microdistrict, Irkutsk, 664049, Russia.

Unlabelled: is to assess the effectiveness of a new neuroanesthetic protocol for treating degenerative lumbar spine diseases in high-risk patients.

Materials And Methods: Two groups of patients with a high risk of anesthesia and surgery determined by the authors' clinical decision support system (CDSS) have been prospectively studied. A new neuroanesthetic protocol was used in the experimental group (EG, n=25), while the control group (CG, n=25) underwent intravenous anesthesia based on propofol and fentanyl.

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Background: The compromised well-being of educators engenders a range of educational, social, and economic issues that cannot be adequately addressed through the mere awareness of risk factors. The present research explores the mediating roles of self-compassion and emotion regulation strategies (cognitive reappraisal and expressive suppression) on the relationship between academic teachers' psychological resilience and mental health.

Methods: A total of 405 academic teachers from four colleges in Tabuk City, Saudi Arabia, participated in the study between September and November 2023.

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Objective: The increasing use of assisted reproductive technologies (ART) has led to a growing interest in the health outcomes of offspring. However, the impact of ART on the immune system of children remains poorly understood. While only two publications were found, their findings contradict each other and did not consider other risk factors in their analysis except for ART use.

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Article Synopsis
  • The study revises three species of the genus Appendisotoma based on specimens collected from the Palaearctic region, highlighting their seasonal variations known as cyclomorphosis.
  • Key features affected by cyclomorphosis include the winter form's distinct characteristics like a prominent lobe, hardened furca, and larger eye spots.
  • A new species, Appendisotoma monomorpha, is introduced from Kazakhstan, and additional taxonomic notes are provided for two existing species.
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The genus Microedus LeConte, 1874 (Omaliinae: Anthophagini), previously known only from North America, is recorded for the Palaearctic fauna for the first time. Two palaearctic genera were synonymized with Microedus: Altaiodromicus Zerche, 1992 syn. n.

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The Pseudepipona lativentris-group includes the species of the nominotypical subgenus of the genus Pseudepipona de Saussure, 1856 with long setae on the gena, the scutum, and the propleuron (former subgenus Trichepipona Blüthgen, 1951). Five species and two additional subspecies were hitherto recognized in this group, while the present taxonomic revision revealed the existence of eight species: P. beckeri (Morawitz, 1867) (Russia, Kazakhstan), P.

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Article Synopsis
  • Five genera within the "Hygrogeus" complex of the Anthophagini tribe are described and illustrated, including Hygrogeus, Trichodromeus, and three new genera: Asiageodromicus, Himalodromeus, and Microhygrodromicus.
  • The genus Hygrogeus includes three species, primarily from the Middle European Alps and Kashmir, while Trichodromeus has 21 species across the eastern Palaearctic Region with several (re-)descriptions provided.
  • Notable changes include a new synonymy for Trichodromeus species and eight new combinations transitioning species from Hygrogeus to Trichodromeus based on updated classifications.
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Article Synopsis
  • Sibling species within bloodsucking black flies complicate the assessment of biodiversity and the species' roles in spreading pathogens, prompting research on molecular genetic structures of Simulium reptans in Russia and Northern Kazakhstan.
  • Genetic analysis revealed distinct mitochondrial DNA variants, identifying two forms: S. reptans A in Northern Europe and S. reptans B in Siberia and Northern Kazakhstan, along with three branches of S. reptans B based on geographic distribution.
  • The study suggests the need for further research in mountainous regions of Eurasia to better understand the ecological adaptations and distribution of these black fly forms.
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Taxonomic, diagnostic and faunistic data for eight species of Hygrodromicus Tronquet, 1981 and three species of Paratrichodromeus Zerche, 1992 (Omaliinae: Anthophagini) from the Middle Asia, the Himalayan Region and China are presented. Three species are (re-) described and illustrated: H. klapperichi Coiffait, 1982 (Afghanistan), H.

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